Rennie

Rennie – the combined drug with antiacid action promoting bystry and long neutralization of excess hydrochloric acid of a gastric juice.

Form of release and structure

Dosage forms of release of Rennie:

• Chewable tablets: square, with concave surfaces, from white with a light brown shade till white color, on two parties an engraving of "Rennie", have a menthol smell (on 2 pieces in strips, in a cardboard pack of 18 strips; on 6 pieces in blisters, in a cardboard pack of 2, 4, 6, 8 or 16 blisters; on 12 pieces in blisters, in a cardboard pack of 1-4 or 8 blisters);
• Chewable tablets (the cooling taste): square, with concave surfaces, from white with a light brown shade till white color, existence of light-cream spots, on two parties an engraving of "Rennie" is admissible, have a menthol smell (on 6 pieces in blisters, in a cardboard pack of 2, 4, 6, 8 or 16 blisters; on 12 pieces in blisters, in a cardboard pack of 1-4 or 8 blisters);
• Chewable tablets without sugar (mint): square, with concave surfaces, white with a creamy shade, on two parties an engraving of "Rennie", have a mint smell (on 2 pieces in strips, in a cardboard pack of 18 strips; on 6 pieces in blisters, in a cardboard pack of 2, 4, 6, 8 or 16 blisters; on 12 pieces in blisters, in a cardboard pack of 1-4 or 8 blisters);
• Chewable tablets without sugar (the cooling taste): square, with concave surfaces, white with a creamy shade, existence of light-cream spots, on two parties an engraving of "Rennie" is admissible, have a mint smell (on 2 pieces in strips, in a cardboard pack of 18 strips; on 6 pieces in blisters, in a cardboard pack of 2, 4, 6, 8 or 16 blisters; on 12 pieces in blisters, in a cardboard pack of 1-4 or 8 blisters);
• Chewable tablets (orange): square, with concave surfaces, white with a creamy shade, on two parties an engraving of "Rennie", have an orange smell (on 6 pieces in blisters, in a cardboard pack of 2, 4, 6, 8 or 16 blisters; on 12 pieces in blisters, in a cardboard pack of 1-4 or 8 blisters).

Active agents as a part of 1 tablet (any dosage form of release):

• Calcium carbonate – 680 mg;
• The main magnesium carbonate – 80 mg.

Auxiliary components as a part of 1 tablet:

• Chewable tablets: sucrose – 475 mg, prezhelatinizirovanny corn starch – 20 mg, potato starch – 13 mg, talc – 33,14 mg, magnesium stearate – 10,66 mg, liquid light paraffin – 5 mg, menthol fragrance (peppermint oil, arabic gum, maltodextrin, silicon dioxide) – 13 mg, lemon fragrance (maltodextrin, lemon oil, water) – 0,2 mg;
• Chewable tablets (the cooling taste): sucrose – 475 mg, prezhelatinizirovanny corn starch – 20 mg, potato starch – 13 mg, talc – 33,14 mg, magnesium stearate – 10,66 mg, liquid light paraffin – 5 mg, ксилитаб 100 (ксилитол ≥95%, a polydextrose) – 25,2 mg, the cooling fragrance (maltodextrin, diethyl malonate, marked a lactate, menthol, the modified starch (E1450), isopulegol) – 15 mg, menthol fragrance (menthol, maltodextrin, the modified starch (E1450) – 15 mg;
• Chewable tablets without sugar (mint): sorbitol – 400 mg, prezhelatinizirovanny corn starch – 20 mg, potato starch – 13 mg, talc – 35,5 mg, magnesium stearate – 10,7 mg, liquid paraffin – 5 mg, mint fragrance – 10 mg, sodium saccharinate – 0,8 mg;
• Chewable tablets without sugar (the cooling taste): sorbitol – 400 mg, prezhelatinizirovanny corn starch – 20 mg, potato starch – 13 mg, talc – 35,5 mg, magnesium stearate – 10,7 mg, liquid paraffin – 5 mg, the cooling fragrance – 15 mg, mint fragrance – 8 mg, sodium saccharinate – 0,8 mg;
• Chewable tablets (orange): sucrose – 475 mg, prezhelatinizirovanny corn starch – 20 mg, potato starch – 13 mg, talc – 33,14 mg, magnesium stearate – 10,66 mg, liquid paraffin – 5 mg, orange fragrance (orange oil, maltodextrin, the purified water) – 35,2 mg, sodium saccharinate – 2 mg.

Indications to use

Rennie is appointed at the symptoms connected about a reflux esophagitis and a hyperoxemia of a gastric juice namely:

• Heartburn;
• Heavy feeling or overflow in epigastric area;
• Periodic pain in a stomach;
• The Dispepsichesky phenomena, including the states connected with reception of medicines, errors in food, abuse of coffee, alcohol, nicotine;
• Dyspepsia of pregnant women;
• Acid eructation.

Contraindications

• Nephrocalcinosis;
• Hypercalcemia;
• Renal failure in a heavy current;
• Hypophosphatemia;
• Age up to 12 years;
• Intolerance of fructose, deficit of isomaltase/invertase, glyukozo-galaktozny malabsorption (for tablets of chewable tablets chewing (the cooling taste));
• Existence of hypersensitivity to drug components.

Route of administration and dosage

Rennie is accepted inside, chewing or holding before full dissolution in a mouth. Drug should be accepted at emergence of the first symptoms.

Single dose – 1-2 tablets. Repetition of administration of drug in 2 hours is in case of need possible.

The maximum dose – 11 tablets a day.

Side effects

Drug at observance of the recommended doses, as a rule, is transferred well.

During Rennie's use it can be observed development of reactions of hypersensitivity to drug components in the form of rash, a Quincke's edema, anaphylactic reactions.

Special instructions

At Rennie's appointment at functional disturbances of kidneys it is regularly necessary to exercise control of serumal concentration of magnesium, calcium and phosphorus.

At functional disturbances of kidneys long therapy in high doses is not recommended.

At reception of high doses of Rennie the probability of formation of stones increases in kidneys.

Each tablet to chewable tablet chewing (orange) / to chewable tablet (the cooling taste) contains 475 mg of sucrose; in a tablet without sugar (mint) / to chewable tablet without sugar (the cooling taste) – 400 mg of sorbitol (use at a diabetes mellitus is possible).

In case of inefficiency of therapy it is necessary to consult at the specialist.

Medicinal interaction

At the combined use of Rennie with some medicinal means / substances the following effects can be observed:

• Thiazide diuretics: interaction development (it is regularly necessary to exercise control of serumal concentration of calcium);
• Antibiotic drugs of a tetracycline row, drugs of phosphates, iron, fluorides, ftorkhinolona, left thyroxine, cardiac glycosides: decrease in their absorption;
• Other drugs accepted at the same time: decrease in their speed and extent of absorption (because of change of acidity of the gastric juice connected with Rennie's reception; other medicines need to be accepted with observance of an interval of 1-2 hours).

Terms and storage conditions

To store in the place, unavailable to children, at a temperature up to 25 °C.

Period of validity of Rennie in blisters:

• Chewable tablets – 5 years;
• Other forms of release – 3 years.

Period of validity of Rennie in strips – 2 years.