Sialis

Sialis – the drug which is applied at disturbances of an erection.

Pharmacological action of Sialis

Active ingredient of Sialis is tadalafit. This chemical compound belongs to the selection inhibitors of FDE5 enzyme (specific phosphodiesterase of type 5) of tsGMF (cyclic monophosphate guanine riboside). At hit in a blood channel blocking of FDE5 enzyme increases the tsGMF level in a cavernous body of a penis therefore smooth muscles of arteries relax that promotes inflow of blood to a penis and, respectively, emergence or strengthening of an erection.

The possibility of carrying out successful sexual intercourse within 36 hours after administration of drug is a consequence of use of Sialis. In the presence of sexual excitement effect of medicinal substance begins 16 minutes later after reception. Existence of sexual excitement is the defining condition for emergence of effect.

Sialis has no significant effect on arterial pressure and a cordial rhythm. Does not change property of sperm and the main characteristics of spermatozoa.

The maximum concentration of drug in blood is found 2 hours later after reception, assimilation by its organism does not depend neither from reception write, nor from that, in the morning or in the evening it is accepted. It is brought out of an organism with a stake (2/3) and with urine (1/3), the period of removal of drug makes about 18 hours.

Form of release and structure

Medicinal substance is produced in the form of tablets of an ovoidny form, coated yellow color, with marking "With 20" on each tablet from the face.

1 tablet contains 20 mg of a tadalafil + excipients (monohydrate of lactose, croscarmellose sodium, sodium lauryl sulfate, microcrystallic cellulose, hydroxypropyl cellulose, magnesium stearate, talc, Opadry II dye).

Tablets are packaged in blisters on 1, 2 and 4 pieces, 1 packaging contains 1 or 2 blisters and Sialis's instruction.

Sialis's analogs

Drugs Tadalafil and the Generic Sialis incorporating the same active agent belong to Sialis's analogs. From the point of view of the effect which had by drug the following medicines also belong to Sialis's analogs: Levitra, Viagra, Generic Viagra, Sealeks, Sealeks forte, Laveron, Impaza and some other.

Indications to use

According to the instruction Sialis is applied at inability of achievement and/or preservation of an erection sufficient to have sexual intercourse, i.e. at erectile dysfunction, especially vascular and psychoemotional origin.

Application instruction of Sialis

According to the instruction Sialis is applied by per os, the tablet needs to be washed down with enough water. It is necessary to accept drug not less than in 16 minutes prior to alleged carrying out sexual intercourse.

The daily dose of drug makes 20 mg of 1 times a day, i.e. one tablet a day, is not recommended to increase this dose, as well as to accept drug more often than once a day.

As there is an individual sensitivity to drug, the patient is recommended most to observe behind in what time within 36 hours after reception Sialis's action will be the most effective in his case.

Side effects

Reviews of Sialis testify to its good tolerance and safety at use according to the instruction. Nevertheless, the following undesirable effects connected with its reception were in practice recorded:

• Headache;
• Symptoms of dyspepsia (nausea, heartburn, pain in epigastric area, disturbances of a chair and so forth);
• Rushes of blood to the person, the century swelled;
• Dizziness attacks;
• Dorsodynia;
• Muscular pains;
• The increased perspiration;
• Rhinorrhea, conjunctiva hyperemia (noninfectious conjunctivitis);
• Allergic phenomena (small tortoiseshell, exudative erythema, Quincke's disease).

The most frequent are a headache, the dispepsichesky phenomena and rushes of blood to the person, other side effects meet extremely seldom. For their elimination it is enough to stop reception of this medicine, having replaced it any of Sialis's analogs which are not containing tadalafit.

Some reviews of Sialis speak about a possibility of disturbance of cordial activity as a result of its use for the patients having pathology of cardiovascular system namely emergence of tachycardia, stenocardia, sometimes even a myocardial infarction or a stroke. However specialists claim that such phenomena are connected, most likely, not with effect of drug, and with sexual excitement. Nevertheless, use of this medicinal substance is undesirable in those cases at which sexual activity is not recommended.

Contraindications to Sialis's use

Sialis's use is contraindicated in the following cases:

• Age up to 18 years;
• Hypersensitivity to the tadalafil or other ingredients which are a part of this medicine;
• Parallel reception of nitratsoderzhashchy drugs;

Also administration of drug at the persons suffering from a priapism, Peyroni's disease, a sickemia, leukemia, a multiple myeloma, the inborn or acquired deformations of a penis is undesirable. Sialis's use in a combination with other medicines for treatment of erectile dysfunction can be unsafe and therefore it is also not recommended.

Overdose

During the researches it was established that considerable exceeding of a dosage both concerning a single dose, and concerning the frequency of reception of Sialis led to emergence of the standard side effects stopping after drug withdrawal. Nevertheless, the overdose of medicine is not recommended, in view of insufficiency of information on the remote effects, in particular, to possibility of medicinal dependence.

Rules of storage and Sialis's issue

Drug is stored in the dry place out of access of direct sunshine, at a temperature which is not exceeding 30 °C. Period of validity 3 years.

To protect from children.

It is released according to the recipe of the doctor.