Veroshpiron

Veroshpiron is the diuretic applied against hypostases.

Pharmacological group: kaliysberegayushchy diuretics.

The international name is conformable with active ingredient: Spironolactonum.

Structure and form of release

Veroshpiron is issued in the form of tablets on 0,025 g of active ingredient in everyone. In 1 packaging on 20 and 100 таб.

Pharmacological properties

In the instruction to Veroshpiron drug is described as kaliysberegayushchy diuretic.

The main active ingredient competes with Aldosteronum (adrenal hormone) and slows down its action. Na +, Cl-and water are not soaked up back in renal tubules, and K+ and urea on the contrary, get through an endothelium of a vascular ball into blood. Strengthening of an urination causes a lowering of arterial pressure and disappearance of hypostases. The diuretic effect is shown only in 3-5 days after the first day of administration of drug.

Veroshpiron significantly does not influence function of renal tubules and does not lead to an acid-base imbalance of an organism.

Indications to Veroshpiron's use

Indications to Veroshpiron:

• at the hypostases connected with heart diseases (chronic heart failure), endocrine system (Conn's disease, a polycystosis of ovaries, a hirsutism);
• at arterial hypertension;
• at the ascites connected with cirrhosis;
• at wet brain and other diseases which are followed by hypostases;
• at heavy burns;
• at the paroxysmal paralysis connected with deficit of calcium;
• at a myasthenia (as means for auxiliary treatment).

Application instruction of Veroshpiron and dose

Veroshpiron's use is possible only on doctor's orders.

At cirrhosis a daily dose of drug sostavlyaet100 mg, 200 mg or 400 mg a day (the dose depends on complexity of course of a disease).

At a nephrotic syndrome the daily dose makes from 100 to 200 mg.

At an edematous syndrome accept from 100mg/days up to 200 mg/days three times a day.

Veroshpiron appoint daily 5 days, then gradually reduce a daily dose and lead up to 25 mg or raise to 400 mg in 4 receptions.

With the increased arterial pressure Veroshpiron appoint 50-100 mg of means a day, once, or in 4 receptions, for 2 weeks. Medicine can be combined with hypotensive drugs.

At a hypopotassemia accept 25-100 mg at one time or to 400 mg in stages.

At primary hyper aldosteronism Veroshpiron appoint 100, 200 or 400 mg a day in 4 receptions before operation and on 25-50 mg at prolonged treatment.

At a polycystosis syndrome in ovaries and a hirsutism Veroshpiron's use comes down to 100 mg of drug twice a day.

To children appoint 1-3.3 mg/kg (30-90 mg/kg a day), accept once or in 4 receptions. For the 5th day the dose can be adjusted and if necessary to increase by 3 times.

On reaching effect Veroshpiron's dose goes down to 0,025 g a day, and accept on 1 таб later. 4 times a day every 3 day.

By-effects

According to reviews about Veroshpirona drug can cause drowsiness, dizziness, digestive disturbances, a dermatosis, disturbance of a menstrual cycle and sexual function, block, a poshatyvaniye when walking, muscular spasms, change of a picture of blood (мегалобластоз, thrombocytopenia, an agranulocytosis).

Overdose

According to reviews about Veroshpirona of patients, the overdose with drug arises extremely seldom.

In case of its emergence all side effects of medicine escalate. It is necessary to wash out urgently a stomach, to use a large amount of liquid and caffeine for increase in arterial pressure.

At a hyperpotassemia the doctor appoints a dextrose and insulin.

Contraindications to Veroshpiron's use

Drug cannot be accepted at a renal failure, a diabetes mellitus with complications, hypersensitivity to any of components of drug, Addison's disease, increase in level of potassium and calcium in blood, at a liver failure, pregnancy, gynecologic diseases.

Veroshpiron take at blockade of conductivity in a cardiac muscle, at surgical interventions, reception of hormonal medicines, anesthetics, at advanced age with caution.

Special instructions

During Veroshpiron's reception it is necessary to limit receipt in an organism of potassium and to control function of kidneys and a condition of blood.

Interaction

The instruction to Veroshpiron warns that drug weakens effect of anticoagulants, strengthens effect of adrenaline, cardiac glycosides and lithium. Kortikosterioda and diuretics strengthen Veroshpiron's effect, and non-steroidal anti-inflammatory drugs - weaken his action.

Storage conditions

Veroshpiron it is necessary to store in the cool place for up to 5 years.