АнвиМакс

АнвиМакс – medicine of the antihistaminic, antiviral, anesthetizing, febrifugal and angioprotektivny action.

Form of release and structure

АнвиМакс is issued in the following forms:

• gelatinous solid capsules, size No. 0 (two types): capsules P – blue color, contents – mix of granules and powder of color, white or white with a pinkish or creamy shade, sometimes with lumps; capsules P – red color, contents – mix of granules and powder of color, white and yellow or yellow with a greenish shade, sometimes with lumps (on 10 pieces of capsules P in a blister strip packaging and on 10 pieces of capsules P in a blister strip packaging, in a cardboard pack on one blister strip packaging of capsules of different color);
• powder for preparation of solution for intake (crimson, lemon, cranberry, blackcurrant, lemon with honey): mix of granules and powder from almost white color to yellow with a greenish shade, having a characteristic smell (depending on a type of powder – raspberry, a lemon, a cranberry, blackcurrant or a lemon with honey), sometimes come across single pink granules; the prepared solution slightly muddy, colourless or with a yellowish shade, has a characteristic smell (depending on a type of powder), there can be not dissolved yellow particles (on 5 g at the thermowelded bags, at a cardboard pack 3, 6, 12 or 24 bags).

Structure of 1 capsule P:

• active ingredient: paracetamol – 360 mg;
• auxiliary components: silicon dioxide colloid, polysorbate 80, lactoses monohydrate, starch prezhelatinizirovanny, magnesium stearate;
• structure of a cover of the capsule: gelatin, titanium dioxide, dye diamond blue or dye blue patent.

Structure of 1 capsule P:

• active ingredients: ascorbic acid – 300 mg, Rimantadinum a hydrochloride – 50 mg, gluconate calcium monohydrate – 100 mg, лоратадин – 3 mg, rutoside – 20 mg;
• auxiliary components: magnesium stearate, potato starch;
• structure of a cover of the capsule: gelatin, titanium dioxide, dye crimson, dye ferrous oxide yellow, dye ferrous oxide red.

Structure of 1 bag of powder:

• active ingredients: ascorbic acid – 300 mg, paracetamol – 360 mg, Rimantadinum a hydrochloride – 50 mg, gluconate calcium monohydrate – 100 mg, лоратадин – 3 mg, rutoside – 20 mg;
• auxiliary components: silicon dioxide colloid, aspartame, lactoses monohydrate, a gipromelloz, fragrance (depending on a type of powder – crimson, lemon, cranberry, blackcurrant or lemon with honey).

Indications to use

• symptomatic therapy of a SARS, flu and other catarrhal diseases which are followed by a headache, temperature increase, a fever and muscle pains (at adult patients);
• causal treatment of flu of A type.

Contraindications

Absolute:

• hemorrhagic diathesis;
• renal failure;
• нефроуролитиаз;
• acute diseases of a liver and/or kidneys (acute hepatitis, acute pyelonephritis, acute glomerulonephritis);
• exacerbation of chronic diseases of a liver and/or kidneys;
• gastrointestinal bleedings;
• portal hypertensia;
• hemophilia;
• sarcoidosis;
• aggravation of erosive cankers of digestive tract;
• avitaminosis To;
• the expressed hypercalcuria, hypercalcemia;
• prothrombinopenia;
• alcoholism;
• fenilketonuriya (for Anvimaks in the form of powder);
• diseases of a thyroid gland;
• deficit of lactase, syndrome of glyukozo-galaktozny malabsorption;
• simultaneous use of cardiac glycosides;
• the children's and teenage age is younger than 18 years;
• period of pregnancy and lactation;
• hypersensitivity to drug components (to one or several).

Relative (Anvimaks apply with care):

• diabetes mellitus;
• urolithiasis;
• electrolytic disturbances;
• calcic нефроуролитиаз (in the anamnesis);
• diarrhea;
• hypercalcuria;
• hyperoxaluria;
• dehydration;
• sideroblastny anemia;
• hemochromatosis;
• thalassemia;
• deficit glyukozo-6-fosfatdegidrogenazy;
• cerebral atherosclerosis;
• epilepsy.

Elderly patients with arterial hypertension should apply Anvimaks with care.

Route of administration and dosage

Capsules
АнвиМакс in the form of capsules accept inside after food, washing down with water. The single dose for adult patients makes on 1 capsule P and 1 to the capsule P. Frequency rate of use – 2-3 times a day.

Powder for solution preparation
АнвиМакс in the form of powder accept inside, previously having dissolved contents of one bag in ½ glasses of warm boiled water. Drug should be used right after solution preparation. A single dose – 1 bag, frequency rate of use – 2-3 times a day.

Duration of treatment makes 3-5 days. If the state does not improve, it is necessary to stop administration of drug and to see a doctor. АнвиМакс do not apply more than 5 days.

Side effects

• alimentary system: dyspepsia, lack of appetite, damage of a mucous duodenum and stomach, dryness of a mucous membrane of an oral cavity, diarrhea, meteorism;
• central nervous system: a tremor, a headache, a hyperexcitability, rushes of blood to the person, dizziness, drowsiness, a hyperkinesia;
• endocrine system: glucosuria, hyperglycemia;
• system of a hemopoiesis: change of indicators of blood;
• urinary system: moderate pollakiuria;
• allergic reactions: an itch, rash on skin, a small tortoiseshell.

At aggravation the specified collateral action or emergence of any other undesirable reactions it is necessary to report about it to the attending physician.

Special instructions

АнвиМакс it is not recommended to apply in the presence of the metastasizing tumors.

Patients with alcohol addiction before treatment have to consult with the specialist as paracetamol can have the damaging effect on a liver.

During therapy by drug of Anvimaks it is necessary to drive especially attentively the car and to be engaged in other work demanding high concentration and bystry reaction.

Medicinal interaction

At simultaneous use of paracetamol with uricosuric drugs their efficiency decreases. High doses of paracetamol increase effect of anticoagulants. Metoclopramidum can increase paracetamol absorption speed. Barbiturates (at prolonged use) reduce efficiency of paracetamol. Ethanol, gepatotoksichny drugs, rifampicin, tricyclic antidepressants, Phenytoinum, phenylbutazone and barbiturates increase risk of development of heavy intoxications even at insignificant overdose of paracetamol. Inhibitors of a microsomal oxidation reduce probability of a hepatotoxic action.

Ascorbic acid improves absorption of iron preparations in intestines, increases concentration of benzylpenicillin in blood, at simultaneous use with streptocides of short action and salicylates increases probability of development of a crystalluria, increases removal of the drugs having alkali reaction and slows down removal of acids, at a concomitant use with Deferoxaminum can increase iron removal, reduces chronotropic action of an izoprenalin, reduces concentration of oral contraceptives in blood, increases clearance of ethanol (it, in turn, reduces concentration of ascorbic acid in an organism), reduces a canalicular reabsorption of tricyclic antidepressants and amphetamine, reduces therapeutic effect of the neuroleptics which are derivatives of a fenotiazin. At simultaneous use with Primidonum and barbiturates its removal with urine increases.

Rimantadinum at joint reception with caffeine strengthens its exciting effect.

Concentration of a loratadin in blood increases at simultaneous use with CYP3A4 and CYP2D6 inhibitors.

Terms and storage conditions

To store in the dry place protected from light at a temperature no more than 25 °C. To protect from children. A period of validity – 2 years.