Авонекс – interferon, drug for treatment of multiple sclerosis.
Active agent: interferon beta 1а, its contents in 1 bottle of lyophilisate and 1 syringe with solution makes 30 mkg (6 million international units).
Auxiliary components of lyophilisate: albumine human serumal, sodium hydrophosphate, sodium dihydrophosphate and sodium chloride.
Composition of solvent: water for injections.
Solution excipients: water for injections, arginine a hydrochloride, sodium acetate trihydrate, polysorbate 20, glacial acetic acid.
Авонекс it is intended for intramuscular introduction. Treatment is carried out under control of the doctor which has experience of treatment of the multiple sclerosis (MS).
The recommended dose makes 30 mkg once a week. The injection whenever possible should make at the same time on the same day weeks. The place of an injection needs to be changed every week.
From lyophilisate prepare solution for intramuscular introduction just before an injection.
For reduction of frequency of development and weight of grippopodobny symptoms at an initial stage of therapy titration of a dose can be carried out: treatment is begun about ¼ doses and every week it is increased on ¼ until the full dose is reached (by fourth week).
Avoneks's introduction according to the alternative scheme is possible: treatment is begun about ½ doses once a week, then it is raised to a full dose.
To reduce expressiveness of grippopodobny reaction, before an injection and within 24 hours after each introduction it is recommended to accept a febrifugal analgetic.
Duration of treatment is defined individually. 2 years later after the beginning of therapy of the patient direct to clinical inspection and assessment of the neurologic status on the basis of which results the doctor will make the decision on need of continuation of a course. In case of development of the chronic progressing RS drug should be cancelled.
Rules of use of solution for injections:
Rules of preparation of solution for injections from lyophilisate:
Rules of administration of the solution for injections prepared from lyophilisate:
Each bottle of Avoneks is intended for one injection. The remained drug is not subject to further use.
The most frequent side effect of drug is the grippopodobny syndrome which is shown the following symptoms: fever, feeling of fatigue, a fever, weakness, a headache, muscular pains, nausea (are usually shown in an initiation of treatment and pass in process of use continuation). There are spastic phenomena and passing muscular weakness, up to reversible paralysis of extremities less often (these manifestations can pass and appear again, are usually short).
During any period of treatment there can be neurologic symptoms similar to an aggravation of a multiple sclerosis: the muscular weakness and/or episodes of muscular spasms limiting autokinesias (these episodes usually appear after drug injections, in certain cases are followed by grippopodobny symptoms).
The following side effects are less often observed:
At Avoneks's appointment it is necessary to warn patients about need of the immediate address to the doctor in case of symptoms of a depression or suicide thoughts.
Except usual laboratory analyses which are carried out at multiple sclerosis during treatment it is necessary to carry out biochemical analysis of blood (including to check activity of enzymes of a liver), to define a leukocytic formula, to control a pattern of peripheral blood with calculation of uniform elements (including thrombocytes). In case of symptoms of a miyelodepressiya more careful blood analysis can be required.
During treatment by Avoneks in blood serum can appear interferon - the neutralized antibodies reducing activity of interferon of beta la and, as a result, efficiency of drug. According to the available data, 12 months of therapy of an antibody later to interferon beta 1а appear in serum approximately at 8% of patients.
Interferon beta 1а can exert a negative impact on the speed of reactions and ability to concentration of attention.
In case of pregnancy at women with high frequency of RS recurrence the doctor has to compare a ratio of risk of a heavy recurrence owing to Avoneks's cancellation and the increased probability of spontaneous abortion at continuation of its reception.
Special researches on an occasion of interaction of Avoneks with other medicinal substances / drugs were not conducted. According to clinical data, patients with RS during an aggravation have beta interferon 1а it is possible to apply along with glucocorticosteroids or adrenocorticotropic hormone.
It is established that interferona can reduce activity of enzymes of system of P450 cytochrome therefore with care along with Avoneks it is necessary to use drugs which clearance substantially depends on this system, for example, antidepressants and antiepileptic means.
To store in the unavailable to children, protected from light place at a temperature: lyophilisate – no more than 25 ºС, solution – 2-8 ºС (not to freeze). Solution is allowed to be stored at a temperature of 15-30 ºС, but no more than 1 week.
Period of validity – 2 years.
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