Garazon

Garazon – the combined drug with antiinflammatory and antibacterial action for topical administration in the LOR-expert and ophthalmology.

Form of release and structure

Garazon release in the form of drops eye and ear (on 5 ml in polyethylene bottles droppers; on 1 bottle in a cardboard pack).

Active agents are a part of 1 ml of drops:

• Betamethasone (in the form of betamethasone sodium phosphate) – 1 mg;
• Gentamycin (in the form of gentamycin sulfate) – 3 mg.

Auxiliary components: the purified water, a dihydrate hydrosodium phosphate, a dihydrate dihydrosodium phosphate, sodium chloride, a sodium citrate dihydrate, sodium borate, эдетат dinatrium, chloride a benzalkoniya (as preservative).

Indications to use

• Keratoconjunctivitis and for the second time the infected conjunctivitis;
• Staphylococcal blefarokonjyunktivit;
• Keratitis;
• Blepharitis;
• Dacryocystitis;
• The injuries of front department of an eye got because of corrosive and thermal burns, impact of radiation, hit of foreign bodys and also during the postoperative period;
• Episcleritis;
• Meibomitis (internal barley);
• Eczema of outside acoustical pass, outside otitis (acute and chronic).

Contraindications

• Viral diseases of a conjunctiva and cornea (for example, at chicken pox);
• The keratitis caused by a herpes simplex virus (a treelike keratitis);
• Fungal or mikobakterialny infections of an ear or eye;
• The states which are followed by thinning of a sclera and cornea (for example, after removal from a cornea of a foreign body);
• Trachoma;
• Perforation or lack of a tympanic membrane;
• Age up to 6 years;
• Pregnancy (except cases when the advantage for mother exceeds potential risk for a fruit) and the lactation period (because of a lack of information);
• Hypersensitivity to drug components.

Carrying soft contact lenses during treatment is not recommended (because of availability in Garazon's list of chloride a benzalkoniya).

Patients need to apply drops with care with an open angle glaucoma, a myopia of high degree, at a diabetes mellitus in the family anamnesis and infections caused by a herpes simplex virus.

Route of administration and dosage

At treatment of diseases of eyes the doctor defines a dosage individually. As a rule, dig in 3-4 times a day 1-2 drops in a conjunctival sac of the affected eye. It is possible to increase the frequency of use of drug in an acute stage to 2 drops each 1-2 hours. After improvement frequency rate of use is reduced. The general duration of topical treatment is defined by character and disease severity. At absence within 14 days of therapeutic effect further use of Garazon is inexpedient.

At treatment of diseases of an ear outside acoustical pass before use of drug should be cleared. The recommended initial dose – 3-4 drops, frequency rate of use – 2-4 times a day. The patient has to lie on one side with the affected ear turned up, after a solution instillation for ensuring penetration of drug in acoustical pass it is necessary to remain some more minutes in this situation.

At reduction of expressiveness of the inflammatory phenomena the dosage is gradually reduced. Therapy is stopped after disappearance of symptoms of a disease.

If necessary in outside acoustical pass it is possible to enter the cotton plug impregnated with solution which needs to be supported further wet, moistening with drug each 4 hours. The tampon is replaced in 24 hours.

At chronic diseases of ears and eyes the termination of therapy is carried out, gradually reducing use frequency.

Side effects

After Garazon's instillation perhaps short-term emergence of burning sensation, dryness or an itch of skin in the place of use.

The side effects connected with influence of drops Garazon on eyes:

• Glucocorticosteroids: a mydriasis, glaucoma, increase in intraocular pressure, development of a back subkapsulyarny cataract, damage of an optic nerve, perforation of a cornea and sclera, narrowing of fields and decrease in visual acuity, an acute front uveitis, penetration of air bubbles after surgical treatment of a cataract, the slowed-down healing of wounds, development of consecutive infection of eyes (for example, Herpes Zoster), a ptosis and disturbance of accommodation;
• Antibiotic drugs: allergic reactions.

At use of Gentamycini sulfas there were also messages on passing irritation of eyes.

Special instructions

Drug is intended only for topical administration. Subconjunctival introduction and Garazon's use directly in an anterior chamber of an eye is forbidden.

Lack of bystry medical effect during use of drug forms the basis for specification of the diagnosis.

At preservation of symptoms of a disease or at its recurrence for definition of sensitivity of the activator to antibiotics it is necessary to conduct a bacteriological research.

At Garazon's appointment for a period of 10 days it is necessary to measure intraocular pressure. Tonometriya of eyes is recommended to be seen off using a slit lamp. Patients in whose family anamnesis there is an open angle glaucoma, a myopia of high degree and a diabetes mellitus treat risk group of increase in intraocular pressure as a result of topical administration of glucocorticosteroids.

It is known that at the diseases causing thinning of a sclera or cornea, topical administration of glucocorticosteroids can lead to perforation of an eyeglobe. Because of it it is not recommended to begin treatment of helcomas of a bacterial etiology which can be caused by Pseudomonas aeruginosa with use of a combination of an antibiotic and a glucocorticosteroid. In this case in an initiation of treatment it is reasonable to use only antibacterial drugs. If the response to antibacterial therapy is, accession to treatment of anti-inflammatory drug for the prevention of formation of a hem of a cornea and minimization of fibrous reaction is possible.

Glucocorticosteroids at acute purulent processes in an eye can mask or exponentiate already existing infection.

At treatment of the infections caused by a herpes simplex virus, glucocorticosteroids need to be applied with extreme care.

Long topical administration of glucocorticosteroids or antibiotics can lead to increase in growth of insensitive microorganisms, including mushrooms.

Between various glucocorticosteroids and aminoglycosides development of cross allergic reactions was noted.

To avoid cross infection and pollution, to use one bottle of drug for simultaneous therapy of an infection of an ear and an eye does not follow. When using a bottle dropper more than one person, spread of an infection is possible.

At long therapy, Garazon it is necessary to cancel gradually.

Medicinal interaction

Information on interaction with other medicines is absent.

Terms and storage conditions

To store in the place, unavailable to children, at a temperature up to 25 °C.

Period of validity – 3 years.