Glyurenorm

Glyurenorm – derivative generation sulphonylurea II, the peroral hypoglycemic drug having pancreatic and extra pancreatic effects.

Form of release and structure

Dosage form – tablets: round, smooth, white color, with slanted edges, on one party – an engraving of a logo of firm, on another – risk, on both sides of which an engraving "57C" (on 10 pieces in blisters, 3, 6 or 12 blisters in a pack cardboard).

Active ingredient: гликвидон, in 1 tablet – 30 mg.

Additional substances: starch corn soluble, the starch which corn is dried up magnesium stearate, lactoses monohydrate.

Indications to use

Glyurenorm – drug for treatment of a diabetes mellitus 2 types at patients of middle and advanced age (on condition of inefficiency of a dietotherapy).

Contraindications

Absolute:

• Diabetes mellitus of 1 type;
• Diabetic acidosis and ketoacidosis, prekoma and coma;
• The acute alternating porphyria;
• Rare hereditary diseases: deficit of lactase, galactosemia, glyukozo-galaktozny malabsorption, lactose intolerance;
• Heavy liver failure;
• State after a pancreatectomy;
• Some acute states (such as infectious diseases and extensive surgeries);
• Age up to 18 years;
• Pregnancy and lactation;
• Individual hypersensitivity to components of drug or other streptocides.

Relative:

• Deficit glyukozo-6-fosfatdegidrogenazy;
• The diseases of a thyroid gland which are followed by disturbance of its function;
• Feverish syndrome;
• Alcoholism.

Route of administration and dosage

Glyurenorm accept inside according to recommendations of the doctor for a dose, and also observance of a diet.

At the beginning of therapy, as a rule, appoint ½ tablets during a breakfast (at the beginning of meal). If improvement of a state is not noted, the dose is gradually raised.

If the daily dose does not exceed 2 tablets, it should be accepted in 1 morning reception. If exceeds – it is necessary to divide into 2-3 receptions, but to accept the most most part in the morning at breakfast.

The most admissible daily dose makes 4 tablets. Increase in a dose more than 4 tablets is inexpedient as does not lead to increase in efficiency.

It is not necessary to miss meal after Glyurenorm's reception and to cancel drug without consultation of the doctor.

At purpose of drug in a dose more than 75 mg (2,5 tablets) careful control of a state is necessary for patients with an abnormal liver function.

In case of insufficient clinical effect when performing monotherapy by Glyurenorm the combination therapy in combination with Metforminum can be appointed.

Side effects

• System of a hemopoiesis: leukopenia, thrombocytopenia, agranulocytosis;
• Nervous system: drowsiness, вертиго, paresthesia, headache, feeling of fatigue;
• Cardiovascular system: premature ventricular contraction, hypotension, stenocardia, cardiovascular insufficiency;
• Alimentary system: nausea, a loss of appetite, dryness of an oral cavity, feeling of discomfort in a stomach, lock/diarrhea, vomiting, a cholestasia;
• Metabolism: hypoglycemia;
• Organ of sight: accommodation disturbances;
• Skin and hypodermic cellulose: reaction of a photosensitization, urticaria, rash, itch, Stephens-Johnson's syndrome;
• Others: thorax pain.

Special instructions

Glikvidon – active ingredient of Glyurenorm – treats derivatives of sulphonylurea of short action therefore 2 types with the increased risk of development of a hypoglycemia, for example, of elderly people and patients with a renal failure are applied to treatment of patients with a diabetes mellitus. Removal of a glikvidon kidneys slightly, and therefore drug can be used at patients with a diabetic nephropathy and renal disturbances. However at a heavy renal failure treatment should be carried out under careful observation of the doctor.

There are data that Glyurenorm is effective and safe for patients with a diabetes mellitus 2 types having associated diseases of a liver except for heavy functional disturbances.

Patients with a diabetes mellitus have to adhere to recommendations of the doctor strictly. In case of their non-compliance decrease in concentration of glucose in blood is possible that can lead to a loss of consciousness. At administration of drug before food, but not as it is recommended – at the beginning of meal, Glyurenorm's influence is more expressed because of what the risk of development of a hypoglycemia increases.

Glyurenorm should not replace a medical diet.

At emergence of signs of a hypoglycemia it is necessary to accept immediately carbohydrates (the products/drinks containing sugar or glucose). If the hypoglycemic state remains, it is necessary to see the attending physician immediately.

The exercise stress can strengthen hypoglycemic effect of drug. The stress and alcohol can both strengthen, and to reduce its action.

At insufficiency of a glyukozo-6-phosphate-dehydrogenase derivatives of sulphonylurea can lead to hemolitic anemia. As also Glyurenorm treats this group, it is necessary to apply him with care, and whenever possible – to make the decision on drug change.

Data on Glyurenorm's influence on the speed of reactions and concentration of attention are absent. However patients need to be warned about probability of emergence of such symptoms of a hypoglycemia as accommodation disturbance, dizziness and drowsiness which can arise during treatment. For this reason it is recommended to be careful at control of vehicles and performance of potentially dangerous types of works. At development of hypoglycemic states it is necessary to refrain from driving of the car and work with mechanisms.

Medicinal interaction

Strengthening of hypoglycemic action of Glyurenorm at co-administration of the following drugs is possible: monoamine oxidase inhibitors, non-steroidal anti-inflammatory drugs, analgetics, antifungal means, tricyclic antidepressants, tetracyclines, insulin, other peroral hypoglycemic drugs, angiotensin-converting enzyme inhibitors derivative of coumarin, cyclophosphamide and its derivatives, ftorkhinolona, streptocides, Sulfinpyrazonum, Clofibratum, кларитромицин, chloramphenicol, Allopyrinolum.

Sympatholytics (including a clonidine), beta adrenoblockers, гуанетидин and Reserpinum can not only strengthen hypoglycemic effect of drug, but also at the same time mask hypoglycemia symptoms.

Reduction of hypoglycemic action of Glyurenorm at co-administration of the following drugs is possible: sympathomimetics, glucocorticosteroids, thyroid hormones, thiazide and loopback diuretics, oral contraceptives, niacin drugs, аминоглутетимид, фенотиазин, diazoxide, glucagon, rifampicin, Phenytoinum, barbiturates.

At simultaneous use of ethanol, blockers histamine _{H2 receptors} (for example, ranitidine, Cimetidinum) are possible both strengthening, and easing of hypoglycemic effect of Glyurenorm.

Terms and storage conditions

To store in the dry place unavailable to children, at a temperature not above 25 °C.

Period of validity – 5 years.