Хиберикс

Structure of Hiberiks

1 dose of Hiberiks contains 10 mkg of the capsular polysaccharide emitted from a strain of Hib 20, 752 containing about 30 mkg of anatoxin. As excipients are used: lactose - 10,08 mg on 1 dose. Solvent: chloride sodium solution of 0,9% - 0,5 ml on 1 dose.

Description

Хиберикс is a vaccine against Haemophilus influenzae (V), is issued in the form of powder or the mass of white or gray-white color.

Indications to use

Хиберикс it is applied to prevention of hemophilic b of infections, children since age have 6 weeks and up to 5 years. Хиберикс has no preventive effect on other Haemophilus influenzae types and bacterial meningitis of other etiology.

Contraindications

Individual intolerance of components of a vaccine, including tetanic anatoxin. Manifestation of allergic reactions to the vaccines Haemophilus influenzae (B) entered earlier.

At acute diseases - infectious and noninfectious, and also at chronic diseases in a stage of an aggravation carrying out an inoculation not less than in a month after recovery is admissible. At the respiratory, intestinal and other infections proceeding benign carrying out an inoculation on condition of normalization of body temperature is admissible.

To patients with HIV infection use of Hiberiks is allowed.

Dosage of Hiberiks and application instruction

Age from 6 weeks to 6 months: the inoculation consists of three repetitions at an interval of 1, either 1,5, or 2 months. In various countries different schemes of vaccination are accepted. The revaccination is carried out once on the second year of life. It is recommended to combine an inoculation of Hiberiks with vaccination against whooping cough, poliomyelitis, tetanus and diphtheria.

Age from 6 months to one year: the inoculation consists of two repetitions with an interval of 1 month. The revaccination becomes once on the second year of life. Combination of vaccination by Hiberiks with vaccination against whooping cough, poliomyelitis, tetanus, a rubella, diphtheria, parotitis and measles is admissible.

Age from 1 year to 5 years: single vaccination becomes, introduction of a vaccine is made intramusculary. To patients with pathologies of coagulant system of blood it is entered subcutaneously.

Before Hiberiks's use it is necessary to examine attentively the solvent attached to it on existence of foreign particles, or outward change. At identification of physical particles or discoloration, solution cannot be used.

Before Hiberiks's use the solution which is in a set is brought in a bottle with a vaccine at the rate of 0,5 ml on 1 dose. Drug mixes up by stirring. Usually for full dissolution of lyophilisate enough less than 1 minute. After dissolution drug looks as colourless transparent liquid. If after hashing in drug not dissolved particles are found, or color does not correspond described, such drug cannot be used. After opening of a bottle drug has to be used within one working day. The remains have to be utilized.

Side reactions

After introduction of a vaccine of Hiberiks responses from physicians show possibility in an injection site of insignificant reddenings, puffinesses and morbidities, usually no more than within 48 hours.

Perhaps also manifestation within 48 hours: fevers, losses of appetite, concern, vomiting, diarrhea. Similar reactions were also fixed at simultaneous vaccination by different vaccines.

According to responses of Hiberiks can cause other reactions of an organism to vaccination as:

• allergic reactions (anaphylactoid and anaphylactic), Quincke's disease;

• a hypotonic-hyporeactive episode, faints, spasms (with fever and without), drowsiness;

• apnoea;

• extremity hypostasis in an injection site, local consolidation;

• urticaria, rash.

Interaction with other drugs

Hiberiks's introduction with other vaccines is admissible. At the patients receiving immunodepressive therapy the required immune response can be not received.

Special instructions

Due to the probability of emergence in rare instances of anaphylactic reactions, after an inoculation the patient has to remain under observation of doctors not less than 30 minutes. Hiberiks's introduction intravenously is strictly forbidden!

After carrying out at premature children of vaccination by Hiberiks it is recommended to carry out by the instruction monitoring of their respiratory functions within 48-62 hours.

Storage conditions

Period of validity of substance of a vaccine of Hiberiks - 3 years. Drug with the expired term is subject to utilization. The vaccine is stored at a temperature of 2 - 8 °C in the place protected from light. Drug cannot be frozen. It is necessary to store a vaccine in the place unavailable to children.