Ekzoderil

Ekzoderil – antifungal medicine for local use. The operating component – нафтифин, synthetic anti-mycotic substance of group of allylamines. Ekzoderil possesses fungicidal, fungistatic, bactericidal action. The mechanism of action consists in inhibition of biosynthesis of ergosterol in a fungal cell by impact on a skvalenepoksidaza. Drug does not influence system of P450 cytochrome. Ekzoderil causes a lack of ergosterol and accumulation of squalene in a fungal cell therefore there is a death of a microorganism. Ekzoderil is active concerning dermatophytes (Trichophyton, Epidermophyton, Microsporum), mushrooms of the sort Candida, Sporotrix schenckii, mold mushrooms. Besides, drug works for some gram-positive, gram-negative microorganisms, Malassezia furfur. At topical administration Ekzoderil well gets into all layers of skin, at the same time creating therapeutic concentration.

About 6% of active ingredient get to a system blood stream. Drug is partially metabolized, removed with bile and urine. An elimination half-life – 2-3 days.

Indications to Ekzoderil's use

According to the instruction to Ekzoderil, this drug is used at fungus diseases of skin which are caused by microorganisms, sensitive to a naftifin:

• the epidermophitia of skin folds, feet (caused by Epidermophyton floccosum including);
• the trichophytosis (caused by Trichophyton rubrum, Trichophyton mentagrophytes);
• fungal pathology of a pilar part of the head (microsporia);
• damage of skin of a candidosis etiology;
• onychomycoses;
• chromophytosis;
• the mycoses complicated by a consecutive bacterial infection;
• fungal infection of outside acoustical pass.

Contraindications to Ekzoderil's use

According to the instruction to Ekzoderil, drug is contraindicated at hypersensitivity to a naftifin.

Ekzoderil's use on the damaged sites of skin (wound surfaces, burns) is forbidden.

Route of administration, dosage

Ekzoderil in the form of cream, solution apply only outwardly. Drug is applied on clean dry skin. When processing by drug of affected areas of skin it is recommended to take also a quantity of surrounding healthy fabrics (about 1 cm).

At onychomycoses it is necessary to remove possible amount of the struck nail tissues before putting drug. Apply Ekzoderil one – two times a day. Cream and solution apply with a thin layer on the struck zone and slightly rub. Duration of therapy depends on a disease form, and also specific features of patients (in particular, on the growth rate of nails), sometimes reaches 6 months and more. Duration of treatment is defined by the doctor.

At dermatomycoses the average duration of therapy by Ekzoderil makes 2-4 weeks, at severe forms – up to 8 weeks.

At damage of skin of a candidosis etiology treatment lasts about 4 weeks.

After achievement of clinical recovery 2 more weeks for the purpose of prevention of a recurrence of a disease are recommended to use drug.

At mycosis of outside acoustical pass a small amount of solution of Ekzoderil is applied on a wadded turunda, then put it in an ear for 5-7 minutes twice a day. Treatment duration – not less than two weeks.

It is not recommended to use Ekzoderil under a bandage.

Side effect

Drug is usually quite well transferred what reviews of Ekzoderila from patients testify to. In isolated cases emergence of dryness, erubescence in a site of application of drug, a burning sensation was registered. These phenomena quickly pass, at the same time drug withdrawal is not required.

Ekzoderil's use at pregnancy

At topical administration Ekzoderil has no embriotoksichesky and teratogenic effect. Use of drug during pregnancy, lactations is possible according to strict indications and only to destination and under control of the doctor.

Ekzoderil's interaction with other drugs

In view of lack of systemic action of Ekzoderil and analogs their interaction with other drugs is improbable.

Overdose

At present there are no data on Ekzoderil's overdose.

Responses

Reviews of Ekzoderila from patients and dermatologists speak about high clinical performance of this drug. Ekzoderil well proved in treatment of onychomycoses, dermatomycoses, candidosis damages of skin. Drug is quite well transferred, is rather safe.

Ekzoderil's analogs

Now such analogs of Ekzoderil are registered: Naftifin, Fetimin.

Before use of this drug it is necessary to study in detail the instruction to Ekzoderil. It is necessary to use drug exclusively on doctor's orders.