Endoksan

Endoksan treats group of antineoplastic drugs which have the antiinflammatory, immunodepressive and healing effect. Drug is effective for treatment of oncological diseases at various stages of a current.

Structure and form of release

The main active ingredient – cyclophosphamide of 50 mg.

Endoksan is issued in the form of solution for injections of intra belly introduction, powder for injections and tablets of the prolonged action.

Pharmacological properties of Endoksan

Endoksan is antineoplastic drug of complex action. It effectively alkylates the DNA structural elements and normalizes protein synthesis.

Cyclophosphamide, as a part of Endoksan, possesses immunosuppressive action. The main active ingredient blocks division of malignant cells and stops development of oncological diseases.

Endoksan is well soaked up and reaches the maximum concentration in a blood plasma within 3-4 hours. Medicine is metabolized and creates several inactive metabolites. Drug is removed from an organism by kidneys with urine. The period of removal makes 10 hours for adults and 5 hours for children.

Endoksan received good comments as effective drug as a part of complex therapy at treatment of malignant new growths and lymphatic disturbances.

Indications to Endoksan's use

Endoksan appoint for treatment of the following diseases:

• malignant new growths – a breast cancer, sarcoma, Vilms's tumor, a prostate cancer, cancer of a uterus, mycosis, a reticulosarcoma, germinogenny tumors, a myeloma of various etiology;
• lymphatic system – a lymphoid leukosis, a lymphoma, a neuroblastoma, etc.;
• the progressing autoimmune disorders.

Endoksan has positive reviews as effective medicine for treatment of a serious illness of connecting fabric.

Application instruction of Endoksan

According to the instruction Endoksan in the form of solution for injections it is necessary to enter 4-6 mg of 1 times a day within 3-5 days. If necessary the dosage can be increased to 10 mg within 20 days. The attending physician has to define an exact dosage of Endoksan at treatment and a maintenance therapy.

Endoksan in the form of solution for infusions it is necessary to mix from 0,9% solution of sodium of chloride and to enter within 30-50 minutes. The dosage has to be appointed according to a stage of a course of an oncological disease.

According to the instruction Endoksan in tablets appoint to accept 50-150 mg of 1 times a day. The course of treatment lasts from 10 to 40 days.

During treatment it is necessary to control constantly a condition of a liver and circulatory system. To patients with diseases of cardiovascular system the minimum dosage of Endoksan is appointed.

Contraindications

Endoksan is contraindicated to appointment at individual intolerance and hypersensitivity to components of drug, a galactosemia, the increased content of glucose in blood, pregnancy and a lactation, cystitis, disturbances of functioning of a brain, a renal and liver failure, a serious illness of bodies of a GIT, thrombosis, a stroke, at children's age.

With care drug is appointed at infectious diseases, gout, heart diseases and at advanced age.

Side effects of Endoksan

During treatment Endoksan can cause the following side reactions:

• from cardiovascular system – arrhythmia, a leukopenia, myocarditis, heart failure, a myocardial infarction;
• from the blood circulatory system – anemia, thrombocytopenia, a neutropenia, thrombosis;
• from the alimentary system – nausea, vomiting, diarrhea, a meteorism, a lock, disturbances of functioning of a liver, colitis, hepatitis, a peptic ulcer;
• from urinogenital system – an urethritis, bladder fibrosis, cystitis, decrease in a libido, impotence, disturbances of a menstrual cycle, a nephropathy, an amenorrhea, an atrophy of ovaries.

At long reception allergic reactions – a dermahemia, urticaria, an itch, an alopecia, the raised photosensitivity, a Quincke's disease can appear.