Препарат Эсмия выпускают в форме таблеток Esmiya's drug is produced in the form of tablets. Active agent of each tablet are 5 mg of an ulipristal of acetate. Additional components: Mannitolum, microcrystallic cellulose, magnesium stearate, talc, croscarmellose sodium.

In blisters on 14 tablets.

Pharmacological action of Esmiya

According to Esmiya's instruction has antigestagenny effect.

Ulipristal at intake becomes the active synthetic selection modulator of receptors of progesterone rendering partial tkanespetsifichny antiprogesteronovy effect.

Indications to Esmiya's use

According to the instruction Esmiya or Esmiya's analog is appointed as preoperative therapy of the expressed and heavy symptoms of a hysteromyoma to women of reproductive age is more senior than eighteen years. Drug or Esmiya's analog should not exceed treatment duration 3 months.

Contraindications

Esmiya's drug is contraindicated in the following cases:

The age is younger than 18 years;
Period of pregnancy and lactation;
Hypersensitivity to an ulipristal or auxiliary components of drug;
The severe form of bronchial asthma which is not giving in to correction by means of peroral GKS;
Bleedings from a vagina of the obscure nature or for the reasons which are not connected with a hysteromyoma;
Breast cancer, uterus, ovaries or neck of uterus.

According to Esimyu it is not necessary to accept longer than three months as there are no safety of use given relatively for the long period.

With care it is necessary to appoint Esmiya's drug at bronchial asthma and a liver or renal failure.

Route of administration of Esmiya and mode of dosing

According to the instruction Esmiya should be accepted inside, on 1 tablet once a day, irrespective of meal. Treatment is begun in the first week of a menstrual cycle.

If the patient missed reception of a tablet, then it has to accept Esmiya's drug as soon as possible. If reception of a tablet was missed more than for 12 hours, then administration of drug is missed then the usual mode of reception of tablets renews.

Use of drug of Esmiya during pregnancy and breastfeeding

Drug and Esmiya's analogs are strictly contraindicated at pregnancy. Besides, ulipristat it is capable to get into breast milk therefore there is a risk of harming health children when breastfeeding. Therefore Esmiya is contraindicated for a lactation.

Side effects

According to reviews Esmiya can cause the following side effects:

Nervous system: dizziness, headache.
Disturbances of mentality: concern, emotional frustration.
Digestive tract: a lock, dyspepsia, a meteorism, abdominal pains, dryness in a mouth, nausea.
Mammary glands and generative organs: inflows, an endometria thickening, an amenorrhea, an oothecoma, a metrorrhagia, allocations from a vagina, unpleasant feelings in mammary glands, morbidity of mammary glands.
Other side reactions: вертиго, increase in body weight, nasal bleeding, an urine incontience, the increased perspiration, an acne, a dorsodynia, muscles and bones, an adynamy, increased fatigue, hypostases.

Medicinal interaction

Эсмию назначают в качестве предоперационной терапии выраженных и тяжелых симптомов миомы матки Gestagena and hormonal contraceptives can reduce Esmiya's efficiency therefore it is not necessary to carry out their concomitant use. The combined use with powerful inhibitors of an isoenzyme CYP3A4 (ритонавир, кетоконазол, нефазодон) leads to increase in quantity of an ulipristal in a blood plasma. And the combined Esmiya's use according to reviews with CYP3A4 isoenzyme inductors (carbamazepine, rifampicin, drugs of the St. John's Wort which is made a hole Phenytoinum) promotes decrease in concentration of an ulipristal in a blood plasma.

Special indications of use of Esmiya

Patients should appoint Esmiya according to the instruction only after careful inspection. Before administration of drug of Esmiya it is recommended to exclude pregnancy completely.

As it is not recommended to use hormonal contraceptives during Esmiya's use, it is desirable for women to apply non-hormonal methods of contraception during treatment.

Storage conditions

Esmiya should be stored in dark the place not longer than two years.

The prices in Internet drugstores:

Name of drug

Price

Drugstore

Esmiya of a tablet 5 of mg of 28 pieces

8536 rub.

To buy

Apteka вер.ру, LLC

Esmiya тбл 5 mg No. 28, Gedeon Richter

10022 rub.

To buy

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