Ksenalten

Ksenalten (active component орлистат) – the hypolipidemic drug suppressing action of a lipase (pancreas enzyme), as a result, blocking splitting of fats in digestive tract that interferes with their assimilation. It is recommended for treatment of obesity and for maintenance of stable weight after weight loss in a combination to special diets.

Before Ksenalten's use it is necessary to begin to keep to the low-calorie, balanced diet enriched with vegetables and fruit with the content of fats no more than 30% of the general kalorazh. It is also necessary to undergo inspection for clarification of the reasons of obesity. If obesity is a consequence of a disease, it is necessary to receive medical treatment to an absolute recovery before Ksenalten's use.

Pharmacological action of Ksenalten

Pharmacological action of an orlistat, active component of drug Ksenalten, according to the instruction, consists in lipase inhibition in digestive tract. The inactivated lipase loses an opportunity to split the fats arriving from food. Not split fats are removed with a fecal masses, the calories which are contained in them do not come to an organism that promotes a body degrowth. Concentration of fats in fecal masses occurs in 24-48 hours after reception. Ksenalten inhibits absorption of the fats arriving with food for 30%.

Form of release of Ksenalten

Ksenalten is issued in solid gelatin capsules with a blue lid and white or almost white case. Capsule contents – granules: 120 mg орлистат, 120 mg excipients.

Capsules are packaged in a blister strip packaging from PVC of a film and the varnished aluminum printing foil on 7 or on 21 pieces. Cardboard packs of drug Ksenalten may contain 1, 2, 3, 4, 6 or 12 packagings.

Ksenalten's analogs

Drug analogs Ksenalten on active active ingredient (орлистат) are capsules: Allie, Xenical, Orsoten, Orsoten Slim, Orlimaks.

Drug analogs Ksenalten on the mechanism of influence are not issued.

Indications to Ksenalten's use

According to the instruction, Ksenalten apply:

• For treatment of obesity, weight reduction in combination with low-calorie diets;
• For decrease in risk of repeated set of weight after its dumping;
• In the presence of the diseases interfering weight reduction by other methods such as arterial hypertension, dislipidemiya, diabetes mellitus, at an index of body weight more than 28-30 kg/sq.m.

Contraindications

Ksenalten's use according to the instruction is contraindicated in a case:

• The increased individual sensitivity to an orlistat or auxiliary components of drug;
• Sprue;
• Cholestasia;
• Concomitant use with cyclosporine;
• Pregnancies;
• Lactations;
• Age up to 18 years.

Ksenalten, according to reviews, it is necessary to take with caution at a nephrolithiasis, and also in the presence in the anamnesis of a hyperoxaluria.

Route of administration and Ksenalten's doses

Ksenalten according to the instruction it is necessary to accept on 1 capsule at each meal or not later, than in an hour after it, but no more than 3 times a day. If food does not contain fats, administration of drug can be missed.

Medicinal interaction

The following interactions of medicines at a concomitant use with Ksenalten are revealed:

• Warfarin and other indirect anticoagulants – decrease in level of a prothrombin, change INR (the international normalized relation) is possible. The concomitant use is recommended with constant control of MNO;
• Nutritional supplements – decrease in absorption of a betakaroten by 30%, vitamin E for 60%;
• Pravastatin – increase in bioavailability and hypolipidemic effect due to increase in concentration in plasma for 30%;
• Polyvitaminic complexes – decrease in absorption of A, D, E, K vitamins. It is recommended to accept polyvitamins after Ksenalten's reception not less than in two hours;
• Peroral hypoglycemic drugs – the dose decline owing to a degrowth of a body and improvement of a metabolism from Ksenalten's reception is perhaps necessary;
• Acarbose – data on pharmacokinetic interaction are absent, the concomitant use is not recommended;
• Amiodaronum – decrease in level of drug in plasma. The concomitant use with Ksenalten is possible only according to doctor's instructions;
• Oral contraceptives – the mediated decrease in bioavailability, undesirable pregnancy is possible. Alternative methods of contraception in addition are recommended;
• Cyclosporine – decrease in level of drug in plasma. The two-hour interval between reception of cyclosporine and Ksenalten is recommended;
• Amitriptyline, digoxin, Phenytoinum, fluoxetine, сибутрамин, аторвастатин, nifedipine, лозартан, glibenclamide, furosemide, captopril, атенолол, ethanol – are not revealed essential clinical interactions.

Side effects of Ksenalten

Ksenalten's use, according to reviews, can influence bodies and systems of the patient as follows:

• Digestive tract – discomfort and an abdominal pain, oily kcal and fat allocations, the speeded-up defecation to a meteorism, infectious diarrhea, an incontience a calla, discomfort and rectum pain, nausea, vomiting;
• The central nervous system – a depression, uneasiness, bystry fatigue, sleep disorders, a headache, dizzinesses;
• Respiratory system – infections of upper and lower respiratory tracts, disturbances in work of ENT organs, otitis;
• Urinogenital system – failure of a menstrual cycle, a vaginitis at women, infections of urinary bodies;
• Musculoskeletal system – an arthralgia, a mialgiya, a tendinitis, a dorsodynia and legs, disturbances of work of joints;
• Integuments – a xeroderma, rash;
• Others – various allergic reactions, flu, hypostases.

In case of aggravation of manifestation of the described side effects or manifestation any other at Ksenalten's reception, it is necessary to tell the doctor immediately.

Positive side effect of Ksenalten, according to reviews – decrease in the diseases accompanying obesity, such as diabetes mellitus of the second type, lipidemia and the related risk factors, and also reduction of the internal (visceral) fat accumulating in abdominal organs and a liver.

Ksenalten's use does not influence ability of the patient to manage vehicles and to service driving mechanisms.

Storage conditions

Ksenalten it is recommended to store drug in protected from light, unavailable to children, the dry cool place. A period of validity – 2 years of date on packaging.