Lokoid

Lokoid – a glucocorticosteroid (GKS) for external use.

Form of release and structure

Dosage forms:

• Ointment of 0,1%: fat, soft, translucent, from light gray till almost white color (on 30 g in aluminum tubas, in a pack a cardboard 1 tuba);
• Cream: white color, a homogeneous consistence (on 30 g in aluminum tubas, in a pack a cardboard 1 tuba).

Active agent of Lokoid – a hydrocortisone 17 butyrate: in 1 g of ointment and 1 g of cream – 1 mg.

Additional components of ointment: polyethylene ointment basis (95% of a liquid paraffin and 5% of polyethylene).

Additional components of cream: a macrogoal the 25th cetostearyl ether, cetostearyl alcohol, paraffin white soft, liquid paraffin, sodium citrate anhydrous, citric acid anhydrous, butylparahydroxybenzoate, пропилпарагидроксибензоат, the water purified.

Indications to use

Lokoid is applied to treatment of the superficial, not infected diseases of skin sensitive to local glucocorticosteroids:

• Psoriasis;
• Eczema;
• Dermatitis, including contact, atopic and seborrheal.

Contraindications

Absolute:

• Disturbance of integrity of integuments (existence of wounds or ulcers);
• Fungal infections of skin;
• Viral infections of skin (chicken pox, herpes simplex, shingles);
• Parasitic infections of skin;
• Bacterial infections of skin (stafilo-and streptodermas, gram-negative folliculitis);
• Rozatsea, acne, perioral dermatitis;
• Skin tumors (both malignant, and high-quality);
• Syphilitic and tubercular damages of skin;
• Postvaccinal period;
• Hypersensitivity to drug.

Lokoid with care it is necessary to apply during pregnancy and a lactation.

Route of administration and dosage

Drug is used outwardly – the massing movements ointment or cream apply with a thin layer on affected areas of skin 1-3 times a day. After improvement of a state frequency rate of use can be reduced to 2-3 weekly. In case of the resistant course of a disease (for example, at psoriasis with localization of dense plaques on a lap and/or in elbow areas) Lokoid it is possible to put under occlusive bandages.

The maximum week dose of drug should not exceed 60 g.

In the form of ointment Lokoid is recommended to apply at chronic and subacute processes, especially with dryness, infiltration and lichenification; in the form of cream – at subacute and acute skin processes without moknutiya.

Side effects

Possible local side effects: irritation of skin; seldom – other local reactions inherent to outside steroid therapy.

At use of drug on surfaces, big on the area, and/or under an occlusive bandage or during a long span development of the by-effects inherent to system glucocorticosteroids is possible.

Special instructions

Lokoid it is not necessary to apply on periorbital area since the risk of development of glaucoma is high. In case of systematic hit of drug on a conjunctiva the risk of increase in intraocular pressure appears.

At children's age, and also when using occlusive bandages, prolonged treatment, putting drug on extensive sites of defeat the risk of development of local and system side effects increases.

In the form of ointment it is undesirable to apply medicine on a pilar part of the head, to apply at an acute inflammation, especially exudative, and also at atrophic changes of skin.

For treatment of the skin defeats which are localized in genitals, folds, sites with plentiful indumentum and also in a face, it is preferable to use Lokoid in the form of cream.

If within 2 weeks of therapy the effect is absent, it is necessary to see a doctor for specification of the diagnosis.

When using Lokoid's, as well as any glucocorticosteroid, it is desirable to limit duration of treatment and to appoint minimum possible dose sufficient for stopping of inflammatory process.

At treatment of children it is necessary to consider that the area of the leather processed by drug of a surface should not exceed 20% of the general. In need of putting cream/ointment or under occlusive bandages it is necessary to reduce duration of a therapeutic course by area of the person.

At children's age suppression of function of bark of adrenal glands owing to use of GKS can quicker develop. Besides, decrease in excretion of a growth hormone is possible. At prolonged treatment it is necessary to watch growth and body weight of the child, plasma cortisol level.

There are no data on Lokoid's influence on the speed of reactions and ability to concentration attention.

Medicinal interaction

Information on Lokoid's interaction with other medicines is absent.

Terms and storage conditions

To store at a temperature not above 25 °C. Not to freeze. To protect from children.

Ointment period of validity – 5 years, cream – 3 years.