Methandrostenolone

Methandrostenolone – synthetic steroid drug with the weak androgenic and expressed anabolic action.

Form of release and structure

Methandrostenolone is produced in the form of tablets: white, ploskotsilindrichesky, with a facet (on 1 or 10 pieces in blister strip packagings, on 10 packagings in a cardboard pack).

Is a part of 1 tablet:

• Active agent: метандиенон – 5 mg;
• Auxiliary components: sugar, potato starch, stearic acid.

Indications to use

• Cachexia of various genesis;
• Disturbances of protein metabolism after infectious diseases, severe injuries, burns, radiation therapy, surgeries;
• Osteoporosis of various etiology, the progressing muscular dystrophy;
• Myopathy and osteoporosis (prevention against the background of treatment by glucocorticosteroids);
• Delay of growth at children (a pituitary nanism, Shereshevsky-Turner's syndrome);
• Delay of physical development and puberty (sexual infantility) in boys;
• The encephalopathy developing against the background of alcoholic hepatitis.

Contraindications

• Nephrosis;
• Breast cancer;
• Cancer of chest gland (at men);
• Renal and/or liver failure;
• Hypercalcemia;
• Prostate adenoma;
• Glomerulonephritis (nephrotic stage);
• Pregnancy and period of a lactation;
• Hypersensitivity to drug components.

Route of administration and dosage

Methandrostenolone is accepted inside, it is more preferable – before food.

The adult initial daily dose makes 10-15 mg, its increase up to 30-50 mg is in some cases possible; a maintenance dose – 5-10 mg a day. The maximum doses make: one-time – 10 mg, daily – 50 mg. As a rule, drug is accepted for 1-2 months. If necessary with breaks 1-2 months carry out repeated treatment.

To children Methandrostenolone is appointed in the following daily doses (in 1-2 receptions):

• Up to 2 years: 0,05-0,1 mg/kg;
• 2-5 years: 1-2 mg/kg;
• 6-14 years: 3-5 mg/kg.

Duration of therapy should not be longer than 4 weeks, repeated courses are conducted with an interval of 6-8 weeks.

Side effects

• Bodies of digestive tract: jaundice, functional disturbances of a liver, the dispepsichesky phenomena, including vomiting, nausea, diarrhea, an abdominal pain;
• Cardiovascular system and blood (hemostasis, hemopoiesis): an iron deficiency anemia, a hypocoagulative state with tendency to bleedings, a leukemoid syndrome (in the form of long tubular bone pain, a leukosis);
• Others: peripheral hypostases, progressing of atherosclerosis (in the form of increase in concentration of lipoproteins of low density and decrease in concentration of lipoproteins of high density).

At prolonged use of Methandrostenolone the following side effects can develop:

• Women: virilescence (in the form of steroid eels, increase in fat content of skin, increase in a clitoris, a hirsutism, hoarseness or coarsening of a voice, dis-and amenorrheas), a hypercalcemia (in the form of increased fatigue, oppression of the central nervous system, vomiting, nausea);
• Men: in the prepubertatny period – manifestations of excess androgenic activity (in the form of acne rash, increase in a penis, a priapism, formation of secondary sexual characteristics), an idiopathic hyperpegmentation of skin, the termination or delay of growth (in the form of calcification of epiphyseal growth zones of tubular bones); in the post-pubertal period – irritation of a bladder (in the form of increase in frequency of desires), a gynecomastia, a mastodynia, a priapism, decrease in sexual function; elderly patients have a carcinoma and/or a hyperplasia of a prostate;
• The general: гепатонекроз (in the form of a headache, feeling of discomfort, disturbance of breath, dark a calla, vomitings with blood impurity), a hepatocellular carcinoma, a hepatic purpura (in the form of dark urine, decolouration a calla, small tortoiseshells, pharyngitis or quinsy, dot or makulezny hemorrhagic rashes on mucous membranes and skin), cholestatic hepatitis (in the form of yellow coloring of scleras and skin, pain in right hypochondrium, the darkening of urine decoloured a calla), increase in secretion of sebaceous glands, decrease or increase a libido, a fever, diarrhea, a meteorism, feeling of overpopulation of a stomach, a spasm, a sleep disorder.

Special instructions

For achievement of optimum effect against the background of performing therapy by Methandrostenolone the patient needs to receive adequate amount of fats, proteins, carbohydrates, mineral substances and vitamins with food.

Administration of drug for stimulation of athletic qualities is inadmissible as it can do serious harm to health.

Medicinal interaction

Methandrostenolone at simultaneous use strengthens action of antiagregant, anticoagulants and hypoglycemic drugs, and also side effects of gepatotoksichny medicines.

Terms and storage conditions

To store in protected from light, the place, dry, unavailable to children, at a temperature up to 25 °C.

Period of validity – 5 years.