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Niacinamide

Application instruction:

Form of release and structure

Indications to use

Contraindications

Route of administration and dosage

Side effects

Special instructions

Medicinal interaction

Terms and storage conditions

Niacinamide – vitamin means, on a structure close to niacin.

Form of release and structure

Dosage forms:

Substance-powder (on 1, 5, 10, 15, 20, 25, 30 and 50 kg in bags (sacks) polyethylene, in a fiber drum 1 bag; on 50 kg in bags plastic, in a cardboard drum 1 bag; on 5, 10, 15 and 20 kg in plastic bags);
Tablets 0,025 and 0,005 of (on 50 pieces in packaging);
Solution for injections (1% and 2,5% – in ampoules on 1 ml, 5% – in ampoules on 2 ml, in packaging of 10 ampoules).

Active agent of drug – niacinamide.

Indications to use

Avitaminosis of PP (pellagra);
Diabetes mellitus;
Heart diseases;
Coloenteritis;
Gastritises with the lowered acidity;
Chronic colitis;
Peptic ulcer of a stomach and 12-perstny gut;
Liver diseases;
Hepatitises;
Cirrhosis;
Vyalozazhivayushchy ulcers and wounds.

Contraindications

Stenocardia;
Heavy arterial hypertension;
Hypersensitivity to drug.

Route of administration and dosage

Niacinamide is applied inside, intravenously, intramusculary, subcutaneously.

Medical doses are selected individually depending on weight of avitaminosis of PP, preventive – according to daily requirement.

Inside drug should be accepted after food. The recommended doses:

Pellagra: adults – on 0,05-0,1 g 3-4 times/days, children – for 0,01-0,05 2-3 times/days. The course of therapy makes 15-20 days;
Prevention of a pellagra: adults – 0,015-0,025, children – 0,005-0,01 g. Frequency rate of use –1-2 times a day;
Other indications: adults – 0,02-0,05, children – 0,005-0,01 g. Frequency rate of use – 2-3 times a day.

Parenterally (intramusculary, intravenously and subcutaneously) enter 1-2 ml of solution 1-2 times a day (rate of administering – no more than 0,002 g a minute).

Side effects

At reception of high doses of Niacinamide are inside possible: diarrhea, dizziness, arrhythmia, a xeroderma and a mucous membrane of eyes, thirst, nausea, vomiting, a mialgiya, a round ulcer, a hyperuricemia, a glucosuria, a hyperglycemia, the exhausting skin itch.

At patients, it is long using drug, the cholestasia and fatty dystrophy of a liver are sometimes noted.

After intravenous administration in rare instances there are allergic reactions in the form of a skin itch, rash and stidor breath.

Special instructions

The balanced food, than Niacinamide use is more preferable to prevention of a hypovitaminosis of PP.

During treatment by drug it is necessary to control function of a liver. For the purpose of the prevention of development of fatty dystrophy it is recommended to include the products rich with methionine in a diet, or to accept methionine and other lipotropic medicines.

Niacinamide is not intended for use as hypolipidemic drug.

To reduce irritant action of tablets of Niacinamide on a mucous membrane of digestive tract, they are recommended to wash down with milk.

Medicinal interaction

Information on interaction with other medicines is absent.

Terms and storage conditions

To store at a temperature up to 25 ˚С. Not to subject to impact of a sunlight and moisture.

Period of validity – 5 years.

Whether you know that:

Blood of the person "runs" on vessels under huge pressure and at disturbance of their integrity is capable to shoot of distance to 10 meters.

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