Nomigren

Nomigren – the non-narcotic anesthetizing drug with protivomigrenozny activity.

Form of release and structure

Nomigren release in the form of tablets, coated: dark pink, round, biconvex (on 10 or 20 pieces in polypropylene tubas, on 1 tuba in a cardboard pack).

Active agents are a part of 1 tablet:

• Ergotamine tartrate – 0,75 mg;
• Caffeine – 80 mg;
• Propyphenazone – 200 mg;
• Mecloxamine citrate – 20 mg;
• Chloride of a kamilofin – 25 mg.

Auxiliary components: titanium dioxide, corn starch, monohydrate of lactose, кросповидон, gelatin, talc, magnesium stearate, colloid silicon dioxide, tartaric acid, dye iron oxide red, polysorbate 80, macrogoal 6000, polyacrylate dispersion, karmelloza of sodium.

Indications to use

• Migrenepodobny headaches of vascular genesis;
• Bad attacks of migraine (including followed by aura).

Contraindications

Absolute:

• Organic diseases of cardiovascular system, including the expressed atherosclerosis, an acute myocardial infarction, stenocardia, frequent ventricular premature ventricular contraction, a Bouveret's disease, arterial hypertension;
• Glaucoma;
• Sepsis;
• Obliterating diseases of peripheral vessels;
• The benign hyperplasia of a prostate which is followed by an ischuria;
• Thyrotoxicosis;
• The expressed renal and/or liver failure;
• Lactose intolerance, sprue of galactose/glucose or deficit of lactase (lactose is Nomigren's part);
• Pregnancy and period of a lactation;
• Age up to 15 years;
• Hypersensitivity to drug components.

Relative (Nomigren it is necessary to take with caution in the presence of the following diseases / states):

• Megacolon;
• Sleep disorders;
• Alarming frustration (panic frustration, agoraphobia);
• Migraines with focal neurologic disturbances;
• Simultaneous use with glucocorticosteroids;
• Advanced age.

Route of administration and dosage

Nomigren accept inside, washing down with water, it is more preferable – at the very beginning of an attack.

The recommended dose for the first reception makes 1-2 tablets. If in 30 minutes the state does not improve, drug can be accepted repeatedly in the same dose.

The maximum dose – to 4 tablets a day. In a week it is possible to take no more than 10 pill.

Long therapy is not recommended. In need of prolonged treatment in 7 days of reception of Nomigren it is necessary to take a break for 3-4 days.

Side effects

• Central nervous system: hyperexcitability, sleep disorders; at long therapy – accustoming development;
• Alimentary system: vomiting, nausea; seldom – diarrhea;
• Cardiovascular system: changes on an ECG, tranzitorny tachycardia, increase in arterial pressure, bradycardia, pains in heart, reduction of a pulsation in extremities, muscular pains, paresthesias in extremities (the majority of the specified disturbances is connected with increase in a tone of peripheral vessels);
• Others: weakness in legs; seldom – a skin itch, peripheral hypostases.

Special instructions

Nomigren it is not necessary to apply to prevention of attacks of migraine.

Periodically during therapy it is necessary to control a blood pattern.

It is impossible to exceed the dosages recommended in the instruction, it will help to avoid development of the phenomena of an ergotism (in the form of a spasm of peripheral vessels – anesthesias, paresthesias, feeling of "pricking" in extremities, the lower extremity pains, cyanosis (in particular fingers), the expressed reduction of a pulsation), and also disturbances from the central nervous system (in the form of spasms, a coma, a stupor and dizziness).

At emergence of such symptoms as numbness of finger-tips of feet or brushes, pains in heart, delay or acceleration of heart rate, it is necessary to interrupt immediately therapy and to see a doctor.

Nomigren can exert impact on psychophysical abilities of the patient, in particular at a concomitant use with the alcohol or medicines oppressing the central nervous system. For 2-3 hours after administration of drug it is impossible to manage motor transport and to work with potentially dangerous mechanisms.

Medicinal interaction

At simultaneous use of Nomigren with some medicines there can be following effects:

• Antibiotics of group of macroleads (including erythromycin): increase in concentration of ergotamine in a blood plasma;
• Tricyclic antidepressants, quinidine, амантадин: potentiation of action of Nomigren;
• Ethanol, sedative drugs: strengthening of their effect;
• Nicotine, beta adrenoblockers, alpha адреностимуляторы: strengthening of vasoconstrictive action of Nomigren;
• Serotonin agonists (including суматриптан): increase in risk of development of the prolonged vasospastic reactions.

To avoid development of life-threatening arterial hypertension, it is not necessary to apply Nomigren along with vasoconstrictive drugs.

Terms and storage conditions

To store in the place, unavailable to children, at a temperature up to 25 °C.

Period of validity – 2 years.