Pentaflutsin

Pentaflutsin – the combined medicine for elimination of symptoms of the acute viral and catarrhal diseases anesthetizing, febrifugal and antihistaminic action increasing resistance of an organism.

Form of release and structure

Dosage form of Pentaflutsin – a granule for preparation of solution for intake: mix of granules of cylindrical, round or irregular shape, from flavovirent to white with a creamy shade and white color (in bags from paper of a polymeric covering; in a cardboard pack of 5 or 10 bags).

Content of active agents is 1 bag (5000 mg):

• Paracetamol – 500 mg;
• Ascorbic acid (vitamin C) – 200 mg;
• Calcium gluconate – 200 mg;
• Dimedrol (a difengidramina a hydrochloride) – 20 mg;
• Rutinum (rutoside) – 20 mg.

Auxiliary components: polyvinylpirrolidone (povidone), sugar (sucrose), saccharin soluble (sodium saccharinate), citric acid.

Indications to use

Pentaflutsin is recommended to apply to adult patients to therapy of the following symptoms of ORZ (acute respiratory diseases) and ARVI (acute respiratory and viral infections):

• High temperature;
• Fever, ache in a body;
• Head and muscular pain;
• Nose congestion.

Use drug also for increase in nonspecific resistance of an organism to infection.

Contraindications

• The expressed renal and/or liver failure;
• Blood diseases with tendency to bleedings and hemorrhages;
• Hereditary deficit of enzyme glyukozo-6-fosfatdegidrogenazy (G6PD);
• Hyperoxaluria, нефроуролитиаз (calcic), nephrolithiasis;
• Thrombophilia (tendency to a thrombogenesis);
• Sakharozo-izomaltoznaya insufficiency, glyukozo-galaktozny malabsorption, inborn intolerance of fructose;
• Period of pregnancy of breastfeeding (lactation);
• Children's and teenage age up to 18 years (there are no data of clinical trials);
• Hypersensitivity to any of Pentaflutsin's components.

Take drug at a constitutional hyperbilirubinemia (Gilbert's syndrome) with caution.

In case of need during a lactation breastfeeding for all the time of therapy is required to interrupt uses of medicine.

Route of administration and dosage

Granules accept inside, dissolving contents of 1 bag in 0,5 glasses of hot boiled water.

The recommended dosing mode: 1 bag 3-4 times a day, a therapy course – 3-5 days.

It is necessary to accept only freshly cooked solution, before use it should be shaken up, existence of an insignificant deposit / suspension is allowed.

Side effects

At observance of the recommended dosing mode in rare instances against the background of effect of active components of Pentaflutsin the following side effects are possible:

• Complex of active components: skin allergic reactions, locks, nausea, vomiting;
• Paracetamol: changes of a picture of peripheral blood (a leukopenia, thrombocytopenia, an agranulocytosis), a nephrotoxic and hepatotoxic action (prolonged use in high doses);
• Difengidramin: lacks of coordination of movements and speed of psychomotor reactions, drowsiness, sleeplessness, irritability, euphoria, dizziness, tremor;
• Rutoside: rushes of blood to the person, diarrhea.

In case of observation of any side reactions, their aggravation or manifestation of others, effects which earlier were not noted, it is necessary to report about it to the doctor immediately.

Symptoms of overdose of Pentaflutsin are: stomach aches, nausea, vomiting; in several days signs of damage of a liver are diagnosed, development of a heavy liver failure, encephalopathy and coma is in some cases possible.

For therapy of a state the patient in house conditions should wash out a stomach, to accept adsorbents (absorbent carbon) and to see immediately a doctor. Further symptomatic therapy (an injection of Acetylcysteinum and methionine) is recommended.

Special instructions

It is not recommended to combine Pentaflutsin's reception with alcoholic beverages to avoid toxic damage of a liver.

In the course of therapy it is necessary to be careful, managing vehicles and being engaged in other potentially dangerous types of activity for which speed of psychomotor reactions and the increased concentration of attention is necessary.

Patients with a diabetes mellitus should consider that drug contains sugar, in 1 bag – 0,33 XE.

Medicinal interaction

Existence in drug of active ingredients of a wide range of pharmacological activity causes possible medicinal interaction of Pentaflutsin with other drugs / substances.

Paracetamol:

• Uricosuric medicines – are reduced by their efficiency;
• Anticoagulants – are reduced by synthesis of procoagulant factors in a liver (paracetamol use in addition in high doses increases effect);
• Inductors of a microsomal oxidation in a liver (tricyclic antidepressants, barbiturates, rifampicin, Phenytoinum, phenylbutazone), hepatotoxic substances / drugs, ethanol – increase development of hydroxylated active metabolites, causing a possibility of development of intoxications of heavy degree even at insignificant overdose of paracetamol;
• Barbiturates (in case of long use) – reduce efficiency of paracetamol;
• Ethanol – promotes development of acute pancreatitis;
• Non-steroidal anti-inflammatory drugs (NPVP) – at prolonged combined use the risk of development of an analgetic nephropathy, necrosis renal papillary, an end-stage of a chronic renal failure increases;
• Diflunisal – increases probability of development of a hepatotoxic owing to increase by 50% of plasma concentration of paracetamol;
• Miyelotoksichny medicinal substances / drugs – strengthen manifestations of a gematotoksichnost.

Dimedrol (difengidramina hydrochloride):

• Drugs, the oppressing TsNS (central nervous system) and ethanol – a difengidramin the hydrochloride exponentiates their action;
• MAO inhibitors (monoamine oxidase) – strengthen its anticholinergic action.

Ascorbic acid (vitamin C):

• Benzylpenicillin and tetracyclines – raises their concentration in blood;
• The ethinylestradiol including which is a part of oral contraceptives – in a dose of 1000 mg a day vitamin C increases its bioavailability;
• Heparin and indirect anticoagulants – decreases their efficiency;
• Iron preparations – their absorption in a stomach improves, trivalent iron is transformed to bivalent;
• Deferoxaminum – can amplify iron removal;
• Acetylsalicylic acid – decreases its removal with urine and vitamin C removal increases, absorption of ascorbic acid decreases by 30%;
• Salicylates and streptocides of short action – removal of acids is slowed down by kidneys, removal of the drugs having alkali reaction increases (including alkaloids), concentration in blood of oral contraceptives decreases, the risk of development of a crystalluria increases;
• Izoprenalin – decreases chronotropic action;
• Barbiturates and Primidonum – increase removal with urine of ascorbic acid.

Calcium gluconate:

• Quinidine – increase in its toxicity and delay of intra ventricular conductivity of heart is probable;
• Antibiotics of a tetracycline row: form from calcium a gluconate insoluble complexes that reduces antibacterial effect;
• Tetracyclines, digoxin, peroral iron preparations – absorption decreases (it is necessary to observe an interval between their receptions not less than 2 h);
• Tiazidovy diuretics – can strengthen a hypercalcemia and reduce effect of a calcitonin at a hypercalcemia;
• Phenytoinum – decreases its bioavailability;
• Carbonates, salicylates, sulfates – pharmaceutical are incompatible from calcium a gluconate as they form insoluble or almost insoluble salts of calcium;
• Blockers of slow calcium channels – the therapeutic effect decreases.

Interaction of active components of Pentaflutsin: ascorbic acid strengthens pharmacological effect of Rutinum (rutoside).

Acetylsalicylic acid, fresh juice, alkaline drink, oral contraceptives – reduce assimilation and absorption of drug.

Terms and storage conditions

To store in the dry, dark place at a temperature not above 25 °C. To protect from children.

Period of validity – 2 years.