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Pradaksa

The prices in Internet drugstores:

from 678 rub.

Pradaksa – the antitrombichesky and anticoagulating drug used in traumatology and orthopedics for prevention of a venous thromboembolism in the postoperative period. The drugs Warfarin, Phenilinum and Markumar – Pradaksa's analogs. In some reviews of Pradaksa it is said that this drug from all known coagulants the most effective and modern.

Прадакса применяется для профилактики венозной тромбоэмболии в послеоперационный периодDrug in solid opaque capsules with a blue cover is produced. In capsules there are pellets of yellow color. Dabigatrana этексилат – the main active ingredient of this medicine.

Pharmacological effect of drug of Pradaks

Effect of drug consists in suppression of activity of thrombin. Dabigatrana этексилат – the low-molecular substance which does not have pharmacological activity. After intake this connection is very quickly soaked up and at hydrolysis turns in дабигатран. Dabigatran – active, competitive, reversible direct inhibitor of thrombin. This substance suppresses activity of the thrombin connecting fibrin, free thrombin and also inhibits the aggregation of thrombocytes caused by thrombin.

In medical reviews of Pradaksa it is said that efficiency of this medicine decreases by 20% at body weight more than 120 kg. At body weight about 48 kg efficiency of drug increases by 25% (in comparison with patients with average body weight).

Indications to use of drug of Pradaksa

In the instruction to Pradaksa it ukazvatsya that patients should appoint this medicine for prevention of venous or system thromboembolisms after orthopedic operations. Pradaksa is appointed sometimes to patients with fibrillation of auricles for decrease in rates of mortality from cardiovascular diseases.

Application instruction

According to the instruction, Pradaks in the form of capsules should accept one or twice a day (irrespective of meal time). Not to open and wash down the capsule with a large amount of liquid.

For prevention of venous thromboembolisms reception of 220 mg of drug is recommended once a day (2 capsules on 110 mg). Patients with a moderate renal failure need to reduce Pradaksa's dose to 150 mg (two capsules on 75 mg).

After endoprosthesis replacement of a knee joint reception of a medicine should be begun in one-four hours after operation. Right after operation it is recommended to accept one capsule of drug a day (110 mg), and then to increase a dose to two capsules every day. The course of reception makes ten days or 28-35 days (after endoprosthesis replacement of a hip joint).

Patients with fibrillation of auricles need to accept Pradaksa twice a day in a daily dose of 300 mg.

Contraindications to Pradaksa's use

According to the instruction, Pradaksa and Pradaksa's analogs cannot be accepted at the known hypersensitivity to any of means components, at heavy degree of a renal failure, at the active clinically significant bleeding pharmacological induced or spontaneous disturbance of a homeostasis. It is not necessary to use drug at abnormal liver functions, malignant new growths, and also at intracraneal hemorrhage in the anamnesis, spine injuries or brain injuries in the anamnesis, a digestive tract ulcer, a gullet varicosity, intracerebral or intraspinal vascular disorders.

Simultaneous use of Pradaksa and antiagregant increases risk of development of bleedings three times. Use of this medicine in a combination with other anticoagulants is contraindicated.

There are no clinical data on effects of reception of this medicine by patients aged up to 18 years.

Precautionary measures

Прадаксу могут назначать пациентам с фибрилляцией предсердий Pradaksa and Pradaksa's analogs should be used with care at the states connected with the increased risk of bleedings. During treatment by drug bleedings of various localization can develop. Decrease in concentration of a hematocrit and/or hemoglobin in blood which is followed by a lowering of arterial pressure is the basis for search of a bleeding point.

Side effect of Pradaksa

In many reviews of Pradaksa it is said that prolonged use of drug for prevention sometimes is followed by emergence of a small tortoiseshell, rash, itch, a bronchospasm, diarrhea, an abdominal pain, dyspepsia. Sometimes against the background of reception of this medicine thrombocytopenia, anemia, a gastroesophageal reflux disease, a gastroesophagitis, a hyperbilirubinemia, a hamaturia, urogenital bleedings, a skin hemorrhagic syndrome develop.

Pradaksa storage conditions

Pradaksa in bottles or blisters is stored at a temperature not above 25 °C. It is necessary to store means no more than three years. After opening of a bottle drug is recommended to be used within a month.

The prices in Internet drugstores:

Name of drug

Price

Drugstore

Pradaksa of the capsule 110 of mg of 10 pieces

678 rub.

Аптека вер.ру, ОООApteka вер.ру, LLC

Pradaksa of the capsule 75 of mg of 10 pieces

692 rub.

Аптека вер.ру, ОООApteka вер.ру, LLC

Pradaksa капс 110 mg No. 10, Boehringer Ingelheim

699 rub.

Сеть московских аптек ИФКNetwork of the Moscow drugstores of IFC

Pradaksa капс 75 mg No. 10, Boehringer Ingelheim

710 rub.

Сеть московских аптек ИФКNetwork of the Moscow drugstores of IFC

Pradaksa of the capsule 150 of Mg of 30 pieces

1742 rub.

Аптека вер.ру, ОООApteka вер.ру, LLC

Pradaksa of the capsule 110 of mg of 30 pieces

1752 rub.

Аптека вер.ру, ОООApteka вер.ру, LLC

Pradaksa капс 110 mg No. 30, Boehringer Ingelheim

1819 rub.

Сеть московских аптек ИФКNetwork of the Moscow drugstores of IFC
 
 
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