Thioridazine

Thioridazine – antipsychotic medicine.

Dosage form and structure

Drug is produced in the form of round, biconvex tablets. One tablet contains active ingredient – thioridazine a hydrochloride of 10 or 25 mg.

Additional components: potato starch, calcium stearate, monohydrate of lactose, sugar, talc, gelatin, main magnesium carbonate, pasechny wax, povidone, pigmental titanium dioxide.

In polymeric banks on 60 tablets.

Pharmacological action

The neuroleptic which is to piperidinovy derivatives of a fenotiazin. Influences on peripheral and central nervous systems, renders tranquilizing, antiemetic, antipsychotic, antipruritic and antidepressive action.

Indications to Thioridazine use

According to the instruction Thioridazine is shown in the following cases:

• maniac-depressive psychosis;
• tics, disease of Gentington;
• the heavy behavior disorders which are followed by aggression and inability to long concentration of attention;
• schizophrenia;
• the behavior disorders which are followed by the increased psychomotor excitability at children;
• psychomotor arousing different character;
• the psychotic frustration which are followed by overexcitement and hyperreactivity;
• the skin diseases which are followed by a painful and severe itch;
• abstinence syndrome (alcoholism, toxicomania);
• serious and moderate depression at adults;
• the neurosises which are followed by the excitement, fear, a sleep disorder suppressed by mood, obsessional neurosis.

Contraindications

• hypersensitivity;
• pregnancy and breastfeeding;
• porphyria;
• children's age up to four years;
• acute depressions;
• heavy arterial hypotension;
• craniocereberal injuries;
• pheochromocytoma;
• hypo - and aplastic diseases of blood;
• comas of various etiology;
• heavy cardiovascular insufficiency;
• the progressing general diseases back and a brain.

According to reviews it is necessary to appoint Thioridazine with care in the following cases:

• breast cancer;
• alcoholism;
• closed-angle glaucoma;
• pathological disturbances of blood;
• Parkinson's disease;
• renal or liver failure;
• syndrome to Reja;
• prostate hyperplasia;
• vomiting, cachexia;
• the diseases appealing thromboembolic disturbances;
• the chronic diseases causing breath disturbance;
• stomach ulcer and 12-perstny gut;
• myxedema;
• epilepsy.

Route of administration of Thioridazine and mode of dosing

On the instruction Thioridazine is intended for intake. The mode of dosing is set individually, depending on indications.

At schizophrenia, a mania, acute psychoses and the agitated states an ambulatory appoint a dosage of 150-400 mg a day, stationary – 250-800 mg a day. As a rule, treatment is begun with a low dosage in 25-75 mg a day, in a week gradually increasing it to necessary. The antipsychotic effect of Thioridazine is according to reviews noted in 10-14 days.

Duration of therapy makes several weeks.

As a maintenance therapy Thioridazine accept in a dosage 75-200 mg a day before going to bed.

To elderly patients, as a rule, appoint Thioridazine in doses of 30-100 mg a day.

Cancellation of Thioridazine is carried out gradually.

At psychosomatic frustration the dosage of drug makes 10-75 mg a day.

At easy emotional disturbances the recommended dosage of drug makes 30-75 mg a day, at average emotional frustration Thioridazine appoint in a dosage 50-200 mg a day.

The Thioridazine dosage for children depends on age:

• 4-7 years – 1-2 таб. (10-20 mg) in the days divided into 2-3 receptions;
• 8-14 years – 2-3 таб. (20-30 mg) in the days divided into three receptions;
• 15-18 years – 3-5 таб. (30-50 mg) in the days divided into three receptions.

Side effects of Thioridazine

According to reviews Thioridazine can cause the following side effects:

• Alimentary system: anorexia, increase in body weight, diarrhea, vomiting, hypoptyalism, intestinal impassability, thermal control disturbance, hypertrophy of nipples of language, cholestatic hepatitis.
• Cardiovascular system: tachycardia, hypotonia.
• Central nervous system: agitation, parkinsonism, confusion of consciousness, photophobia, faints, dispepsichesky and extrapyramidal frustration, sleeplessness, late dyskinesia, excitement, vision disorders, decrease in a convulsive threshold.
• Urinary system: dysuria, inconscience with overflow.
• System of a hemopoiesis: thrombocytopenia, leukopenia, pancytopenia, granulocytopenia, eosinophilia, thrombocytopenia, agranulocytosis, aplastic anemia.
• Allergic reactions: skin rash, itch, exfoliative dermatitis, erythema, nose congestion, bronchospasm, Quincke's disease.
• Reproductive system: gynecomastia, dysmenorrhea, decrease in a libido, false positive tests for pregnancy, giperprolaktinemiya, priapism, disturbance of an ejaculation.

Prolonged use of high dosages of Thioridazine according to reviews can cause a skin melanosis.

Medicinal interaction

Combined use of Thioridazine with:

• amphetamine strengthens antagonistic effect of drug;
• antidiabetic drugs strengthens their hepatotoxic action;
• levodopa reduces its protivoparkinsonichesky action;
• anti-hypertensive drugs strengthens their action, there is a risk of orthostatic hypotension;
• guanetidiny reduces its anti-hypertensive action;
• anti-thyroid drugs increases risk of development of an agranulocytosis;
• tsizapridy, Pimozidum, erythromycin, probucol, Disopyramidum, quinidine, astemizoly and prokainomidy promotes lengthening of an interval of QT.

Thioridazine reduces efficiency of the means reducing appetite, efficiency of emetic action of Apomorphinum and increases its oppressing action by TsNS.

Thioridazine storage conditions

Thioridazine is stored in the dry place at the room temperature not longer than three years.