Zinnat

Zinnat is the tsefalosporinovy antibiotic of the second generation applied at the bacterial infections caused by microorganisms, sensitive to drug.

Pharmacological action

Bacteriostatic (suppresses reproduction of bacteria) and bactericidal (causes death of bacteria) properties Zinnat are caused by his ability to break synthesis of a cell wall of a microorganism.

Active ingredient of drug Zinnat – tsefuroksy which shows activity concerning the majority of gram-positive and gram-negative aerobic bacteria.

Process of absorption of digestive tract considerably accelerates if Zinnat to accept an antibiotic along with food.

The maximum concentration of drug in blood can be observed in 2-3 hours after drug use. Zinnat by kidneys in an invariable look is brought.

Indications to use

The instruction recommends to appoint Zinnat at:

• infections of upper and lower respiratory tracts: infection of bodies of a thorax after operation, abscess of lungs (accumulation of pus in pulmonary fabric), bacterial pneumonia, the infected bronkhoekstaza (the expansion of a part of a bronchial tube having irreversible character), acute or chronic bronchitis;
• LOR-infections: tonsillitis (inflammation of almonds), pharyngitis (throat inflammation), acute average otitis (ear inflammation), sinusitis (inflammation of adnexal bosoms of a nose);
• infections of urinogenital system: acute or chronic pyelonephritis (an inflammation of kidneys), an urethritis (an urethra wall inflammation), cystitis (a bladder inflammation), a symptomless bacteriuria (colonization by bacteria of urinary tract), gonorrhea (the infectious disease caused gonokokky);
• diseases of skin and soft tissues: эризипелоид (infectious damage of skin), phlegmon (a purulent inflammation of cellulose), a furunculosis (formation of multiple furuncles), impetigo (the formation of pustules caused stafilo-and streptococci), a wound fever (reproduction in a wound of causative organisms), a pyoderma (the skin disease provoked by pyogenic bacteria), an ugly face (a skin inflammation. caused by a streptococcus);
• diseases of bones and joints: septic arthritis (penetration of microorganisms into a cavity of joints), osteomyelitis (purulent inflammation of a bone), etc.;
• infections of bodies of a small pelvis: cervicitis (inflammation of a neck of uterus), adnexitis (inflammation of appendages of a uterus), endometritis (inflammation of a mucous membrane of a uterus);
• sepsis (the infectious disease caused by hit in blood of toxins, one-celled mushrooms or bacteria);
• meningitis (inflammation of covers back or brain);
• Lyme's diseases (to the person of a bacterium are transmitted through a sting of the infected tick);
• prevention of complications at abdominal organs operations, a thorax, joints, a basin.

Zinnat, responses confirm, is effective at above-mentioned diseases if they are caused by bacteria, sensitive to this drug.

Application instruction Zinnat

The antibiotic Zinnat is issued in the form of tablets, granules for preparation of the suspension intended for intake, powder from which solution for intramuscular and intravenous use prepares. Zinnat in forms for oral administration it is necessary to accept in time or right after food.

Zinnat is recommended to take suspension or a pill within 5-10 days, at Lyme's disease – 20 days. At the majority of infectious diseases the adult Zinnat 250 mg appoint drug twice a day. At pyelonephritis Zinnat an antibiotic is accepted twice a day on 125 mg. At suspicion of pneumonia, heavy respiratory infections, at Lyme's disease of drug Zinnat of 250 mg as the single dose is, not enough, therefore the amount of drug is increased to 500 mg at preservation of double reception in days. At uncomplicated gonorrhea the instruction recommends to accept Zinnat once in number of 1 g. At reception Zinnat suspension should consider that 10 ml of drug correspond to 250 mg of a tsefuroksim.

To children 12 years at the majority of infections are more senior an antibiotic Zinnat is appointed twice a day on 125 mg. To children from 3 months to 12 years the single dose which should be accepted twice a day is calculated by multiplication of 10 mg Zinnat on the child's weight. At severe forms of infections and average otitis to children 12 years are more senior give drug Zinnat 250 mg twice a day, and to children of 3 months – 12 years – 15 mg/kg at the same frequency rate of receptions.

At intravenous and intramuscular administration an antibiotic Zinnat by the adult at the majority of infections is appointed 3 times a day on 750 mg, at severe forms of a disease – the single dose is doubled. To children of an injection Zinnat enter 3-4 times a day, a dose I calculate by multiplication 60 mg of a tsefuroksim on the child's weight. In the presence of clinical indications transition from parenteral use of an antibiotic to tablets or suspension Zinnat is possible.

Side effects

Zinnat responses and clinical trials refer to undesirable effects of drug:

• diarrhea, vomiting, nausea, the increased activity of enzymes of a liver, hepatitis, cholestatic jaundice;
• prothrombinopenia, leukopenia, hemolitic anemia, thrombocytopenia, eosinophilia;
• spasms, hearing disorder, drowsiness, headache;
• fever, urticaria, itch, skin rash, development of an anaphylaxis;
• dysbacteriosis, vaginosis, intersticial nephrite.

In responses about Zinnat information on manifestations of the milkwoman often meets that Candida is explained by the overgrowth of mushrooms of group during reception of this drug.

Contraindications to use Zinnat

According to the instruction, Zinnat is not appointed at:

• hypersensitivity to cephalosporins;
• allergic reactions to penicillin;
• bleedings and diseases of a digestive tract;
• pregnancies;
• feeding by a breast.

Zinnat an antibiotic is not recommended to children 3 months are younger.

Additional information

Zinnat will be suitable for use within 2 years if to carry out its storage at the room temperature.

Ready Zinnat suspension has to be stored in the refrigerator and to be used within 10 days.