Zokson

Zokson – _{alfa1-adrenoblocker}, anti-hypertensive means; drug is effective also at a benign hyperplasia of a prostate as means of the urination reducing frustration.

Form of release and structure

Dosage form – tablets: round or oblong (round – a flat form with an engraving on one of the parties of "ZX 1", oblong – a biconvex form with dividing risky and an engraving of "ZX 2" or "ZX 4" on one of the parties), almost white or white color ("ZX 1": on 15 pieces in blisters, in a cardboard pack 1 or 2 blisters; "ZX 2": on 10 pieces in blisters, in a cardboard pack 1 or 3 blisters; "ZX 4": on 10 pieces in blisters, in a cardboard pack of 3, 9 or 10 blisters).

Active ingredient of Zokson – a doksazozin мезилат, in 1 tablet with an engraving:

• "ZX 1" – 1,213 mg that is equivalent to 1 mg of a doksazozin;
• "ZX 2" – 2,425 mg that is equivalent to 2 mg of a doksazozin;
• "ZX 4" – 4,85 mg that is equivalent to 4 mg of a doksazozin.

Auxiliary components: the cellulose microcrystallic granulated lactose, cellulose microcrystallic, silicon dioxide colloid anhydrous, sodium carboxymethylstarch (type A), magnesium stearate, sodium lauryl sulfate.

Indications to use

• Arterial hypertension – monotherapy and in combination with inhibitors of an angiotensin-converting enzyme (APF), beta adrenoblockers, thiazide diuretics, blockers of slow calcium channels (for achievement of sufficient control of the arterial pressure (AP));
• Treatment of disturbances of an urination at a benign hyperplasia of a prostate at patients with the ABP normal level and arterial hypertension.

Contraindications

• Age up to 18 years;
• Hypersensitivity to a doksazozin, derivatives of quinazoline and components of drug.

With care it is necessary to appoint at orthostatic hypotension, a mitral or aortal stenosis, an abnormal liver function.

During pregnancy/feeding by a breast Zokson's use is possible if the estimated clinical effect for mother exceeds possible threat for the fruit/child.

Route of administration and dosage

Pill is taken inside, irrespective of meal, swallowing entirely (without chewing) and washing down with a small amount of water. Frequency rate of reception – 1 time a day, in the morning or in the evening.

The doctor appoints a dose and duration of treatment on the basis of clinical indications.

The recommended dosing:

• Arterial hypertension: the first dose – 1 mg of 1 times a day (the best time – before going to bed as after reception of the patient has to be surely within 6-8 hours in a prone position because of risk of development of a phenomenon of the first dose, especially against the background of preliminary therapy by diuretics). Then for achievement of required therapeutic effect the dose is recommended to be raised multiply every 1-2 week. Optimal hypotensive effect is usually reached at a daily dose of 8 mg. After achievement of the steady arterial pressure sick it is recommended to transfer to reception of the supporting sredneterapevtichesky daily dose – 2-4 mg. Depending on weight of a state and features of disease purpose of a dose can fluctuate from 1 mg to 16 mg a day, but no more;
• Disturbance of an urination against the background of a benign hyperplasia of a prostate: in the absence of arterial hypertension – 2-4 mg of 1 times a day. The daily dose – 8 mg is maximum.

Usually Zokson accept during the long period.

Side effects

• Cardiovascular system: often, especially at the beginning of therapy – orthostatic hypotension (in rare instances can cause a syncope), hypostases; relationship of cause and effect at clinical trials is not established – a stethalgia, tachycardia, stenocardia, bradycardia, heart consciousness, a myocardial infarction, disturbance of cerebral circulation, arrhythmia;
• Respiratory system: rhinitis;
• Nervous system: drowsiness, dizziness, headache;
• General reactions: indisposition, fatigue, adynamy;
• Alimentary system: nausea.

Besides, at patients with a benign hyperplasia of a prostate development of side effects is possible:

• Nervous system: a hyperexcitability, sleeplessness, dryness in a mouth, paresthesia, a hypesthesia, a tremor, impotence, a priapism;
• Alimentary system: lack of appetite, meteorism, dyspepsia, abdominal pain, lock or diarrhea, increase in activity of liver enzymes, cholestasia, hepatitis, jaundice;
• Respiratory system: short wind, nasal bleeding, bronchospasm, cough;
• Urinary system: urine incontience, dysuria, hamaturia, polyuria, nocturia;
• Musculoskeletal system: weakness in muscles, a mialgiya, an arthralgia, muscular spasms;
• Endocrine system: gynecomastia;
• Sense bodys: sonitus, illegibility of visual perception;
• Dermatological reactions: alopecia;
• Bodies of a hemopoiesis: thrombocytopenia, leukopenia, purpura;
• General reactions: feeling of heat, allergic reactions, urticaria, skin rash, dorsodynia.

Special instructions

Patients with an abnormal liver function доксазозин should appoint with care, especially at a concomitant use of the means which are negatively operating on a liver. At deterioration in functional indicators of a condition of a liver reception of tablets should be cancelled immediately.

The effect of the first reception is especially expressed at a diet with restriction of sodium and the previous therapy with diuretics.

Orthostatic reactions it is possible to warn if the patient adheres to smooth transitions from horizontal position to a standing position.

Alcohol intake increases risk of side effects.

The malignancy of a prostate needs to be excluded prior to Zokson's use.

At patients with a benign hyperplasia of a prostate and arterial hypertension drug effectively influences both pathologies.

During use of a doksazozin by the patient it is recommended to refrain from potentially dangerous types of activity, including control of vehicles and mechanisms.

Medicinal interaction

Manifestations of signs of negative interaction at Zokson's combination to beta adrenoblockers, thiazide diuretics, furosemide, APF inhibitors, blockers of slow calcium channels, antibiotics, uricosuric and peroral hypoglycemic drugs, indirect anticoagulants are noted.

At simultaneous use of Zokson:

• Means for treatment of arterial hypertension can cause mutual strengthening of hypotensive effect;
• Cimetidinum increases concentration of a doksazozin in a blood plasma;
• Indometacin (especially) and other non-steroidal anti-inflammatory drugs, sympathomimetic drugs, estrogen (detain liquid) can promote decrease in hypotensive effect of drug;
• Inductors of a microsomal oxidation in a liver can increase action of a doksazozin, inhibitors – to lower;
• Epinephrinum loses alpha адреностимулирующие effects (there is a risk of development of arterial hypotension and tachycardia).

Terms and storage conditions

To store in the place protected from light at a temperature of 10-25 °C. To protect from children.

Period of validity – 3 years.