Ambrosan

Ambrosan – mucolytic drug with sekretolitichesky, sekretomotorny and expectorant action.

Form of release and structure

• Tablets: a round form, flat, almost white color, with risky (on 10 pieces in blisters, in a cardboard pack 2 blisters);
• Solution for intake: transparent, colourless or light yellow (on 50 and 100 ml in dark glass bottles droppers, in a cardboard pack 1 bottle complete with a measured glass).

Active agent – Ambroxol a hydrochloride:

• 1 tablet – 30 mg;
• 1 ml of solution – 7,5 mg.

Auxiliary components of tablets: cellulose microcrystallic, magnesium stearate, коповидон, lactoses monohydrate.

Additional substances of solution: a benzalkoniya chloride of 50% solution, citric acid monohydrate, sodium cyclomate, sodium chloride, глицерол, hydrophosphate sodium dodecahydrate, sorbitol of 70% solution, the water purified.

Indications to use

Ambrosan – drug for treatment of the infectious and inflammatory diseases of respiratory system which are followed by formation of a viscous phlegm:

• Chronic obstructive pulmonary disease;
• Acute and chronic bronchitis;
• Pneumonia;
• Bronchoectatic disease;
• Bronchial asthma with difficulty of an otkhozhdeniye of a phlegm.

Contraindications

For both dosage forms:

• I trimester of pregnancy;
• Feeding period breast;
• Hypersensitivity to Ambrosan's components.

In addition for tablets:

• Children's age up to 6 years;
• Rare hereditary diseases, such as glyukozo-galaktozny malabsorption, intolerance of a galactose and deficit of lactase.

With care:

• II and III trimesters of pregnancy;
• Peptic ulcer of a stomach and 12-perstny gut;
• Renal and/or liver failure.

Route of administration and dosage

Ambrosan it is necessary to accept inside, during food, with a small amount of liquid.

The recommended doses:

• Adults and teenagers are more senior than 12 years: the first 2-3 days – on 1 tablet or 4 ml of solution 3 times a day, further – on 1 tablet / 4 solution ml 2 times a day or on ½ tablets / 2 solution ml 3 times a day;
• Children of 6-12 years: on ½ tablets or 2 ml of solution 2-3 times a day;
• Children of 2-6 years: on 1 ml of solution 3 times a day;
• Children up to 2 years: on 1 ml of solution 2 times a day.

Maximum daily doses of Ambroxol:

• Adults and teenagers are more senior than 12 years – 90 mg (3 tablets or 12 ml of solution);
• Children of 6-12 years – 45 mg (1,5 tablets or 6 ml of solution);
• Children of 2-6 years – 22,5 mg (3 ml of solution);
• Children up to 2 years – 15 mg (2 ml of solution).

If the doctor did not appoint other, duration of treatment makes no more than 5 days.

Side effects

• Allergic reactions: seldom (> 1/10 000, <1/1000) – urticaria, skin rash, allergic dermatitis; very seldom (<1/10 000) – an acute anaphylaxis, a Quincke's disease;
• From the alimentary system: seldom – a lock or diarrhea; at prolonged use in high doses – nausea, vomiting, a gastralgia;
• From a nervous system: seldom – a headache, weakness;
• From urinogenital system: seldom – a dysuria;
• From a respiratory organs: seldom – dryness of a mucous membrane of an oral cavity and respiratory tracts, a rhinorrhea.

Special instructions

Ambroxol does not exert a negative impact on the speed of reactions and ability to concentration of attention.

With care it is necessary to appoint drug at disturbance of bronchial motility which is followed by the increased formation of surfactant.

Medicinal interaction

Ambrosan it is impossible to apply along with antibechic drugs as they reduce cough and complicate removal of a phlegm.

Ambroxol increases penetration into a bronchial secret of erythromycin, a tsefuroksim, doxycycline and amoxicillin.

Terms and storage conditions

To store in the place protected from light, dry, unavailable to children, with observance of temperature condition from 15 to 25 ºС.

Period of validity of tablets – 3 years, solution – 2 years.