The prices in Internet drugstores:
from 402 rub.
Amzaar – the combined anti-hypertensive means.
Dosage form – tablets, film coated: an oblong biconvex shape, on one of the parties the engraving is put: on tablets of almost white or white color - "AT1", on tablets of pink or light pink color - "AT2" (on 10 pieces in the blister, in a cardboard pack 1 or 3 blisters; on 300 pieces in a polyethylene bottle, in a cardboard pack 1 bottle).
Content of active ingredients of Amzaar in 1 tablet:
Auxiliary components: cellulose microcrystallic, кросповидон, Mannitolum, K30 povidone, sodium carboxymethylstarch, butyl hydroxytoluene, magnesium stearate.
Structure of a cover: hypro rod, gipromelloza 2910, titanium dioxide, talc.
In addition as a part of a cover of tablets with an engraving of "AT2": dye ferrous oxide red, dye ferrous oxide yellow.
Amzaar apply to treatment of arterial hypertension at patients without contraindications to a combination therapy.
With care Amzaar is recommended to appoint: the patient who is on the diet limiting reception of table salt at a hyperpotassemia, a renal failure (the clearance of creatinine (CC) is less than 20 ml/min.) or a hemodialysis, a liver failure (it is lower than 9 points on a scale of Chayld-Pyyu), arterial hypotension, a mitral stenosis, an aortal stenosis, the sick sinus syndrome (SSS) (tachycardia, the expressed bradycardia), a hypertrophic subaortic stenosis, chronic heart failure of not ischemic genesis (the II-IV functional class on NYHA classification), an acute myocardial infarction (and within 4 weeks after it), at the reduced the volume of the circulating blood (VCB) connected with the reception of high doses of diuretics, severe diarrhea, vomiting and other states causing a hypovolemia at advanced age.
Pill is taken in 1 times a day, washing down with a small amount of water, irrespective of meal.
Amzaar's use needs to be begun after preliminary titration of doses of a lozartan and an amlodipin. In case of need it is possible to pass to a combination therapy from separate reception of a lozartan or an amlodipin.
Upon transition from a concomitant use of a lozartan and an amlodipin the dose of drug is appointed according to doses of the previous monotherapy.
Use of tablets is shown to patients who have similar doses of drugs of a lozartan (50 mg) or an amlodipina (5 mg) in insufficient degree control the arterial pressure (AP).
At a renal failure with KK of 20-50 ml/min. sick dose adjustment is not required. At KK it is less than 20 ml/min. and a hemodialysis it is necessary to adjust doses of active components of drug, Amzaar in this case is not recommended to appoint.
At the patients accepting diuretics in high doses, administration of drug is possible when ensuring sufficient completion of OTsK, but only if the dose decline of a lozartan to 25 mg is not required.
At a liver failure (it is lower than 9 points on a scale of Chayld-Pyyu) use of drug is allowed if, according to the doctor, purpose of a lozartan in a dose of 50 mg is possible.
65 years drug are aged more senior appoint to patients with adequate portability of a dose of a lozartan of 50 mg.
The side effects arising against the background of monotherapy lozartany:
The side effects noted at monotherapy amlodipiny:
Because of risk of development of symptomatic arterial hypotension during Amzaar's use, prior to treatment at the patient it is necessary to eliminate deficit of OTsK.
The patients accepting 25 mg of a lozartan a day are not recommended to appoint complex drug.
After cancellation of an amlodipin it is necessary to be careful at purpose of other vazodilatiruyushchy means, individually selecting a dose and an interval of dosing it is necessary to control a condition of the patient.
Use of an amlodipin should be accompanied with the corresponding diet, control of body weight and the use of table salt, respect for strict hygiene of teeth. Regular visit of the stomatologist will allow to avoid bleeding, morbidity and a hyperplasia of gums.
Regular control of content of potassium in plasma at reception of a lozartan is required, especially at a renal failure from elderly patients.
Drug can cause development of a hyperpotassemia therefore it is necessary to be careful in need of co-administration of kaliysberegayushchy diuretics (including Spironolactonum, Triamterenum, amiloride), the kaliysoderzhashchy substitutes of salt, drugs of potassium, heparin and other means increasing potassium concentration in a blood plasma.
With a unilateral or bilateral renal artery stenosis use of a lozartan can cause reversible increase in concentration of an urea nitrogen and creatinine in plasma in patients.
As effect of drug can cause dizziness, it is recommended to be careful at control of vehicles and mechanisms.
Hypotensive action of Amzaar can raise a concomitant use of other antihypertensives.
At simultaneous use of an amlodipin:
On pharmacokinetics of an amlodipin significant effect magnesium - or aluminum-bearing antacids, a sildenafil (in a dose of 100 mg), grapefruit juice, Cimetidinum does not accord a single dose.
Drug does not exert impact on pharmacokinetics of cyclosporine, ethanol, an atorvastatin.
Reception of an amlodipin is shown against the background of the accompanying therapy by thiazide diuretics, inhibitors of an angiotensin-converting enzyme (APF) or alpha adrenoblockers, non-steroidal anti-inflammatory drugs (NPVS).
At a combination to digoxin, Phenytoinum, warfarin and indometacin амлодипин does not influence their linkng with proteins of a blood plasma.
At simultaneous use of a lozartan:
The combination therapy APF inhibitors and the antagonists of receptors of angiotensin (ARA) demands regular control of function of kidneys.
Significant pharmacokinetic interaction with a hydrochlorothiazide, digoxin, warfarin, Cimetidinum and phenobarbital is not established.
To store at a temperature up to 30 °C. To protect from children.
Period of validity: in blisters – 2 years, in a polyethylene bottle – 3 years.
Name of drug
Amzaar тбл п/пл/о 5 mg +50mg No. 30, Hanmi Pharm. Co., Ltd.
Amzaar of a mg tablet 5 +50mg 30 pieces
Amzaar of a mg tablet 5 +100mg 30 pieces
Amzaar тбл п/пл/о 5 mg +100mg No. 30, Hanmi Pharm. Co., Ltd.
The well-known drug "Viagra" was initially developed for treatment of an arterial hypertension.
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