Cefazolin

Cefazolin – semi-synthetic antimicrobic medicine. Reviews of Cefazolin confirm its high antibacterial performance.

Ifizol, Lizolin, Biokhemi Cefazolin, Orizolin, Natsef, Antsef, Tsefazolin-AKOS, Tsefamezin, Tsefezol, Tsefazolin-Fereyn, Tsezolin, Tsefazolin Elfa, Tsefazolin Sandoz, Tsefoprid – Tsefazolin's drugs analogs.

Structure and form of production of Cefazolin

Cefazolin is produced in the form of powder for preparation of solution for intramuscular or intravenous administration (bottles on 0,5, 1 and 2 g). Sodium salt of cefazolin – the operating antibiotic component (500, 1000. 2000 mg respectively rolled into one).

Pharmacological action

Cefazolin – the least toxic tsefalosporinovy antibiotic possessing a wide range of bactericidal action.

According to the instruction Cefazolin shows activity concerning gram-positive bacteria (Staphylococcus spp., synthesizing and not synthesizing a penicillinase, Streptococcus spp., including Corinebacterium dlphtheriae, pneumococci), gram-negative microorganisms (Proteus mirabilis, Salmonella spp., Enterobacter aerogenes, Escherichia coli, Neisseria gonorrhoeae, Shiqella spp, Klebsiella spp., Haemopnylus influenzae, Neisseria gonorrhoeae). Rezistentna to effect of drug mushrooms, rickettsiae, protozoa, viruses, indolpositive strains a protea (P.rettgeri, P.vulgaris, R. morgani).

The maximum concentration of drug is reached in an hour after intramuscular introduction and instantly – after intravenous administration. According to the instruction Cefazolin in therapeutic concentration (90% of the entered dose) remains as a part of blood during 8-12 chasov.90 the % of a medicine is removed by kidneys in steady-state condition.

Indications to use

According to the instruction use of Cefazolin is shown at the following infectious diseases:

• pneumonia, abscess of lungs, pleura empyema;

• peritonitis, endocarditis, osteomyelitis of burn, wound fevers;

• infectious and inflammatory processes in urinary tract;

• infections of soft tissues;

• skin infections;

• infections of the bone and joint device;

• prevention of postoperative complications.

Cefazolin route of administration

According to the instruction Cefazolin according to indications is entered intravenously or intramusculary (kapelno or struyno).

For intramuscular injections solution of an antibiotic is prepared by ex tempore, parting contents of one bottle in 5 ml of water for an injection sterile or isotonic solution of sodium of chloride. The medicine is entered deeply into muscular tissue.

For intravenous jet injections the single dose of an antibiotic is parted in 8-10 ml of isotonic solution of sodium of chloride. The antibiotic should be entered very slowly (within 4-5 minutes).

At intravenous administration with a drop way drug (500 – 1000 mg) is dissolved in 5% solution of glucose or in 150-250 ml of isotonic solution of sodium chloride. Cefazolin should be entered within half an hour (rate of administering - 65-80 drops a minute).

Daily dose of an antibiotic for adults - from 1000 mg to 4000 mg. The daily dose depends on sensitivity of the activator to drug, and also on weight of an infection. The single dose of drug for adults at the infectious and inflammatory processes caused by gram-positive microbes makes 250-500 mg each eight hours.

At infectious diseases of the moderately severe respiratory organs caused by pneumococci, and also infectious and inflammatory processes in urinary tract appoint 500 – 1000 mg of a medicine each twelve hours.

At the infections caused by gram-negative bacteria, the antibiotic is appointed on 500 – 1000 mg by each seven-eight hours. At serious infectious diseases (peritonitis, destructive pneumonia, sepsis, an endocarditis, hematogenous osteomyelitis in the acute period, urological infections) the daily dose of Cefazolin can be increased to 600 mg (maximum). A break between injections - from six to eight hours.

To children drug is more senior than month appoint in a daily dose 20-50 mg/kg of body weight (in stages), at very heavy infections-100 of mg/kg.

Cefazolin use by adults with an impaired renal function is carried out according to the modified scheme (with increase in breaks between injections and gradual reduction of a dose of an antibiotic).

The daily dose of an antibiotic for children with moderate disturbance of secretory function of kidneys makes 60% of a standard daily dose of Cefazolin.

Daily dose of a medicine at a considerable renal failure - 10% of a standard dose. A break between injections - not less days.

Contraindications to Cefazolin use

• hypersensitivity to medicines of group of cephalosporins;

• lactation period;

• children's age up to one month;

• pregnancy.

Side effects of Cefazolin

In responses to Cefazolin it is said that at prolonged use the antibiotic quite often causes diarrhea, vomiting, tachycardia, nausea, allergic reactions – fever, a skin itch, a small tortoiseshell, Stephens-Johnson's syndrome.

In rare instances prolonged use of Cefazolin leads to a renal failure, to hemolitic disturbances.

There are reviews of Cefazolin, confirmatory that intramuscular introduction of an antibiotic often happens painful and can cause consolidation of fabrics in the place of an injection.

Medicinal interaction

One-time use of Cefazolin and "loopback" diuretics leads to blockade of canalicular secretion of an antibiotic.

Combined use of Cefazolin with ethanol promotes emergence of disulfiramopodobny reactions.

Probenetsid and Tsefazolin's combined use in complex therapy leads to disturbance of excretion of an antibiotic.

Storage conditions

To store in the cool, protected from sunshine place, at a temperature not less than 25 °C.