Cerucal

Cerucal – the antiemetic drug blocking dopamine receptors, presented in two dosage forms:

• Tablets are round, flat, white color, with slanted edges. 1 tablet contains 10,54 mg monohydrate of Metoclopramidum of a hydrochloride (active agent) and auxiliary components (the potato starch, monohydrate of lactose, magnesium stearate, gelatin, silicon dioxide besieged);
• Solution for intramuscular and intravenous administration. 1 ampoule of drug contains 10 mg of Metoclopramidum a hydrochloride – active component – and excipients: sodium chloride, sodium sulfite, the EDTA disodium salt, water for injections.

Pharmacological effect of Cerucal

According to the instruction to Cerucal, drug has antiemetic effect, normalizing work of bodies of a digestive tract. Metoclopramidum – the main operating medicine component – selectively blocks serotoninovy and dopamine receptors, preventing passing of impulses on receptors of a brain and reducing sensitivity of the nervous cells responsible for momentum transfer from a duodenum to the emetic center which is in a myelencephalon. Thanks to the exerted impact by drug for work of the autonomic nervous system, Cerucal recovers motility of upper parts of a GIT. Under the influence of Cerucal returns to normal a tone of smooth muscles of walls of intestines and stomach therefore time of evacuation of the digested food in a duodenum decreases, and the peristaltics of a small intestine improves. Besides, Cerucal promotes normal department of bile, reducing symptoms of dyskinesia of a gall bladder and interfering with emergence of cholestatic jaundice. According to the instruction to Cerucal, active ingredient of drug exerts direct impact on Oddi's sphincter, reducing manifestations of its spazmirovaniye.

Despite antiemetic effect of medicine, Cerucal, according to patients, it is not capable to exert medical impact on vomiting of vestibular and psychogenic character.

After oral administration Cerucal is almost completely soaked up from digestive tract, reaching the maximum concentration of Metoclopramidum in blood within an hour. The main therapeutic action of means remains for 12 hours. Metabolism of Cerucal happens in a liver. Drug is removed with urine: in an invariable look, and also in the form of metabolites.

After intramuscular or intravenous administration the medical effect of Cerucal reaches the maximum after 10-15 minutes and 1-3 minutes respectively.

Indications to Cerucal use

Indications to Cerucal are the states connected with disturbance of activity of a digestive tract which are among: heartburn, syndrome of the angry intestines, functional pyloric stenosis. Efficiency of drug extends also to nausea and vomiting of various origin (the medicines caused by reception, disturbances of work of a liver and kidneys, migraine, craniocereberal injuries), the stomach paresis which developed because of a diabetes mellitus. Besides, Cerucal is applied as the means reducing emetic desires when conducting diagnostic testings of digestive tract (in particular, duodenal sounding).

Contraindications

Use of Cerucal is not recommended at:

• To pheochromocytoma;
• Intestinal impassability;
• Bleeding from digestive tract;
• Perforation of a GIT;
• Existence of a prolaktinozavisimy tumor;
• Epilepsy and convulsive attacks.

Drug is not appointed with hypersensitivity to Metoclopramidum and sodium to sulfite, especially to the patients having bronchial asthma and other allergic diseases. Cerucal is not intended for reception by the pregnant women who are in the first trimester of pregnancy and also children up to 3 years. In the second and third trimesters of pregnancy use of medicine is possible only in case of the vital indications. Cerucal according to indications is taken with caution by patients with arterial hypertension, bronchial asthma, the people suffering from disturbances of functions of a liver, hypersensitivity to procaineamide and Procainum.

Side effects of Cerucal

According to reviews to Cerucal, use of drug can provoke the following side effects:

• From the central nervous system: dizziness, sonitus, headache, increased fatigue, sensation of fear, depression, concern;
• From cardiovascular system: tachycardia, agranulocytosis, change of arterial pressure;
• From digestive tract: dryness in a mouth, disturbance of a chair, change of flavoring feelings;
• From endocrine system undesirable symptoms can be shown as change of the amount of estrogen which is followed by disturbance of a menstrual cycle and a gynecomastia;
• Allergic reactions: urticaria, skin itch.

At overdose by drug irritability, confusion of consciousness, a spasm, hyperkinesias, bradycardia, extrapyramidal motive frustration, increase or a lowering of arterial pressure are possible. According to reviews to Cerucal, symptoms of slight poisonings disappear 24 hours later after drug withdrawal. At heavier frustration the symptomatic treatment is recommended.

In the course of treatment by the patient it is recommended to refuse alcohol and occupation potentially dangerous types of activity demanding speed of psychomotor reactions and special attention.

Interaction of Cerucal with medicines

Metoclopramidum at simultaneous use with other drugs reduces absorption of Cimetidinum and digoxin and accelerates absorption of antibiotics, ethanol and paracetamol. Efficiency of Cerucal at a concomitant use with anticholinergics decreases. Administration of injection solution of drug promotes more bystry splitting of B1 vitamin – thiamin.

This instruction to Cerucal is submitted in the fact-finding purposes. Before use of medicine see a doctor.