Enkorat

Enkorat – an anticonvulsant for prolonged use at treatment of focal and convulsive attacks.

Pharmacological action of Enkorat

Active component of Enkorat has sedative and central myorelaxation effect that is connected with decrease in excitability and convulsive readiness of motor zones of a brain.

Besides, Enkorat's use promotes improvement of mood and a mental condition of patients.

Release form

Drug Enkorat is produced in the form of the pink, covered with a kishechnorastvorimy cover tablets of a round form containing active component – sodium Valproatum in number of 200 and 300 mg. On 10 pieces in packaging.

Enkorat's analogs are the following drugs:

• On active component – Apilepsin, Valparin, Depakin, Convulexum;
• On a way of action – Aminalonum, Phenibutum, Anvifen.

Indications to Enkorat's use

According to the instruction Enkorat appoint in cases:

• Big convulsive attacks;
• Small attacks (difficult absentias epileptica and absentias epileptica);
• Focal attacks.

Contraindications

As appears from the instruction, Enkorat it is contraindicated to apply in the following cases:

• At porphyrias;
• At the expressed dysfunctions of a pancreas and liver;
• In the period of a lactation;
• Against the background of hemorrhagic diathesis;
• At the expressed thrombocytopenia;
• In pediatrics up to 3 years;
• At a leukopenia;
• At pregnancy;
• At hypersensitivity to active or to auxiliary components of Enkorat.

Besides, Enkorat mentally retarded children should take with caution, and also at:

• Damage of marrow;
• Diseases of a liver and pancreas in the anamnesis;
• Renal failures;
• Organic lesions of a brain;
• Inborn enzymopathies.

Enkorat route of administration

Enkorat according to the instruction appoint 0,3-0,6 g a day most often divided into two receptions in an initial dosage. Each 3-4 days a dose should be increased by 0,1 g to optimum, but no more than 2,4 g a day. It is not necessary to change independently the scheme of treatment and the accepted Enkorat's dosage. The most effective reception of tablets along with food is considered.

The children's initial and supporting dosage is calculated proceeding from age and body weight.

Enkorat's cancellation is made is long – on an extent from one to two years with a gradual dose decline.

At overdose by Enkorat such side effects as most often amplify:

• Vomiting;
• Hyporeflexia;
• Nausea;
• Breath dysfunction;
• Diarrhea;
• Dizziness;
• Hypomyotonia;
• Miosis;
• Coma.

Medicinal interaction of Enkorat

At Enkorat's use it is necessary to consider that active component of drug strengthens effects of other antiepileptic drugs, for example, of Phenytoinum and a lamotridzhin, and also tranquilizers, timoleptik, MAO inhibitors and ethanol.

Strengthening of effects of active agent of Enkorat is observed at combined use with salicylates.

The probability of development of damages of a liver sharply increases at combined use with other gepatotoksichny means.

Strengthening of oppression of the central nervous system is most often observed at simultaneous use of Enkorat with antipsychotic means, tricyclic antidepressants and MAO inhibitors.

The risk of oppression of a marrowy hemopoiesis increases at a concomitant use of Enkorat with miyelotoksichny means.

Side effects

In an initiation of treatment Enkorat according to reviews can cause the digestive disturbances having, as a rule, passing character. Stomach aches, anorexia, vomiting, nausea, increase in appetite and diarrhea, and in rare instances – a lock and pancreatitis concern to them.

Disturbances of a nervous system at Enkorat's reception according to reviews can lead to development:

• Block;
• Drowsiness;
• Ataxy;
• Dizzinesses;
• Headache;
• Coma;
• Enuresis;
• Dysarthtias;
• Consciousness disturbances;
• Stupor;
• Tremor;
• The changes of behavior and mental state which are expressed as psychoses, a depression, aggression, motive concern, hallucinations, unusual arousing, feeling of fatigue, a hyperactive state or irritability.

Urticaria, skin rash, malignant exudative erythema, alopecia, photosensitization, Quincke's disease according to reviews belong to the most probable allergic reactions at Enkorat's use.

Besides, Enkorat's reception can cause:

• Diplopia, flashing of front sights before eyes;
• Change of body weight (decrease or increase);
• Dysmenorrhea, galactorrhoea, secondary amenorrhea and increase in mammary glands;
• Anemia, thrombocytopenia, leukopenia;
• Peripheral hypostases;
• Hyperbilirubinemia, giperkreatininemiya and giperammoniyemiya.

The risk of development of the side effects which are expressed as abnormal liver functions depends on amount of drug, and at decrease in the accepted dosage, as a rule, decreases or disappears completely.

Enkorat storage conditions

Enkorat treats a number of anticonvulsants of the list B which issue from drugstores is possible only on doctor's orders. A period of storage of tablets – up to three years at observance of the recommended conditions (at a temperature up to 25 °C in the dry place protected from light).