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Lyuteina

Luteinum – the hormonal medicine exerting impact on reproductive system at women.

Form of release and structure

To Luteinum release in the following dosage forms:

  • Tablets vaginal (in blister strip packagings on 15 pieces, on 2 packagings in a cardboard pack);
  • Sublingual tablets (in polymeric bottles on 30 pieces, on 1 bottle in a cardboard pack).

The structure of 1 tablet vaginal and sublingual includes active agent: the micronized progesterone – 50 mg.

Indications to use

  • The deficit of endogenous progesterone which is shown a dysmenorrhea, anovulatory cycles, disturbances of a menstrual cycle, uterus endometriosis, a premenstrual syndrome;
  • Carrying out artificial fertilization (as one of protocol drugs);
  • Treatment of infertility, and also the usual and menacing abortions connected with insufficiency of products of progesterone a yellow body;
  • Complex replacement hormonal therapy (along with estrogen);
  • Correction of a hormonal background at women in the premenopausal period at insufficiency of a lyuteinovy phase.

Contraindications

  • Lactose intolerance, sprue of a glucose/galactose and galactosemia;
  • Vaginal bleedings of the obscure genesis;
  • Malignant new growths of a mammary gland and other hormonedependent malignant tumors;
  • Jaundice with a cholestasia, the expressed functional disturbances of a liver, Dabin-Johnson's syndromes and the Rotor (for sublingual tablets);
  • Lactation period;
  • Hypersensitivity to drug components.

Luteinum should appoint with care after advantage/risk ratio assessment at thrombophlebitis of deep veins, a thromboembolism of a pulmonary artery, stenocardia and a myocardial infarction.

After an abortion therapy can be carried out only after careful cleaning of a cavity of the uterus (after a misbirth it is impossible to apply Lyuteina in the presence of the remains in a cavity of the uterus).

At an amenorrhea drug is appointed only after a pregnancy exception.

Extra care women need to observe at appointment Luteinums with instructions in the anamnesis on a depression or depressions.

During therapy it is not recommended to manage motor transport and to carry out other potentially dangerous types of works.

Route of administration and dosage

Before use Luteinums need to be carried out a palpation of mammary glands and gynecologic inspection that will help to reveal existence of possible contraindications.

The scheme of therapy is defined by the doctor with a clinical picture and specific features of the woman.

Tablets are vaginal:
Luteinum in the form of tablets vaginal needs to enter as it is possible more deeply in a vagina. Just before introduction the tablet can be moistened with water slightly.

The scheme of use of drug is defined by the doctor with a clinical picture and specific features of the woman.

Depending on indications to Luteinum usually appoint as follows:

  • Algodismenorey, a premenstrual syndrome, disturbances of a menstrual cycle, insufficiency of a lyuteinovy phase during the premenopausal period: a single dose – 25-50 mg, frequency rate of use – 2 times a day. Therapy is recommended to be begun with the second phase of the natural or reproduced cycle. Duration of one cycle – 10-12 days, the recommended therapy duration – 3-6 cycles in a row. In the premenopausal period Luteinum should apply before a menopause;
  • Performing replacement therapy (along with estrogen): a single dose – 25-50 mg, frequency rate of use – 2 times a day. Depending on the scheme of replacement therapy to Luteinum apply from 15 to 25 day of a cycle or 1 times in 2-3 days;
  • Secondary amenorrhea in progesteronovy test: a single dose – 50 mg, frequency rate of use – 2 times a day. Therapy duration – 5-7 days. As a rule, bleeding begins for 7-10 day after the end of use of drug;
  • Dysfunctional uterine bleedings: a single dose – 50 mg, frequency rate of use – 2 times a day. Therapy duration – 5-7 days. After that 2 times a day on 25-50 mg from 15 to 25 day of a cycle pass to use Luteinums. The recommended therapy duration – 2-3 cycles in a row;
  • Endometriosis: a single dose – 50-100 mg, frequency rate of use – 2 times a day. Therapy duration – 6 months;
  • The anovulatory and induced cycles usual and the menacing abortions: a single dose – 50-150 mg, frequency rate of use – 2 times a day. Therapy is recommended to be begun in a cycle when pregnancy, or is planned earlier. Luteinum should apply continuously to 18-20 weeks of pregnancy;
  • Carrying out artificial fertilization: a single dose – 150-200 mg, frequency rate of use – 2 times a day. Therapy duration – till 77 in the afternoon after movement of a germ. It is necessary to complete use Luteinums with a gradual dose decline.

Sublingual tablets:
Luteinum in the form of sublingual tablets needs to hold before full dissolution under language then it is recommended to refrain for 10-15 minutes from meal and water.

The scheme of use Luteinums is defined by indications:

  • Premenstrual syndrome and disturbances of a menstrual cycle: a single dose – 1 tablet (50 mg), frequency rate of reception – 3 times a day. Reception duration – 3-6 cycles;
  • Complex replacement therapy (along with estrogen): a single dose – 1 tablet, frequency rate of reception – 3-4 times a day. Luteinum should accept without breaks daily or from 14-16 to 28 in the afternoon a cycle (in cases if the full cycle makes 28 days);
  • Secondary amenorrhea in progesteronovy test: a single dose – 1 tablet, frequency rate of reception – 3-4 times a day. As a rule, bleeding begins for 7-10 day after cancellation Luteinums;
  • Dysfunctional uterine bleedings: a single dose – 1 tablet, frequency rate of reception – 3-4 times a day. Luteinum should accept during 2-3 cycles from 15 to 25 day of a cycle;
  • The usual abortions induced and anovulatory cycles, carrying out programs of artificial fertilization: a single dose – 2-3 tablets, frequency rate of reception – 3-4 times a day. It is necessary to begin treatment for several cycles before the planned pregnancy. Therapy is continued to 18-20 weeks of pregnancy.

Side effects

In most cases Lyuteina is had well.

During therapy can be observed: drowsiness, weakness, increased fatigue, decrease in concentration of attention and memory, headaches, dizziness and depressions. Development of feeling of baseless scare and change of body weight is in some cases possible. Also there are data on isolated cases of developing of acne rash, a hyperemia of integuments, intermenstrual bleedings, amenorrheas, dysmenorrheas, disturbances of outflow of bile, allergic reactions, thromboses. If use Luteinums is begun till 15 in the afternoon a cycle, it can lead to development of bleeding and reduction of a cycle.

At use Luteinums in the form of sublingual tablets there can be a xerostomia and bleeding of gums. Use of drug in high doses can lead to development of a hypochloraemia and hyponatremia that is connected with removal strengthening by kidneys of chlorine and sodium.

In the premenopausal period of Luteinum can hide the beginning of a menopause.

At development of trombotichesky complications, vision disorders and severe headaches therapy should be cancelled.

Special instructions

Before use Luteinums, and also in cases of development of uncharacteristic symptoms it is necessary to consult at the doctor.

Medicinal interaction

At simultaneous use with the drugs inhibiting system of P450 cytochrome, perhaps minor change of plasma concentration of progesterone.

Terms and storage conditions

To store in the place, unavailable to children, at a temperature up to 25 °C.

Period of validity:

  • Tablets vaginal – 2 years;
  • Sublingual tablets – 3 years.
 
 
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