Application instruction:
Mezapamum – the drug having anxiolytic and sedative effect.
Mezapamum is released in the form of tablets (in blister strip packagings on 10 pieces, on 5 packagings in a cardboard pack; in dark glass jars on 50 pieces, after 1 bank in a cardboard pack).
Is a part of 1 tablet:
In the II-III trimesters of pregnancy use of Mezapamum is possible in cases when the advantage of therapy is higher than estimated harm for health of a fruit (it is necessary to avoid use of drug in high doses or it is long).
Mezapamum is accepted inside, it is more preferable – before meal.
The initial adult dose makes 5 mg 2-3 times a day, gradually daily dose is increased to 30 mg (in need cases – to 40 mg). In out-patient conditions usually appoint 5 mg in the morning and at noon, in the evening – 10 mg. An average single dose – 10-20 mg, daily – 30-40 mg. The maximum daily dose in out-patient conditions makes 40 mg, in a hospital – 60-70 mg. Therapy duration – up to 60 days. Carrying out a repeated course with a break is possible not less than 21 day.
To elderly patients and teenagers Mezapamum appoint 10-20 mg in a daily dose.
The single/daily dose for children is defined by age:
At alcoholism for 7-14 days usually appoint 30 mg a day.
To the patients accepting it is long beta adrenoblockers, hypotensive medicines of the central action, hypoglycemic drugs, contraceptive peroral means, cardiac glycosides and anticoagulants it is necessary to appoint Mezapamum with care (precisely it is impossible to predict the nature of interaction of these medicines with Medazepamum).
Therapy should be interrupted in cases of development of the increased aggression, excitement, sensation of fear, thoughts of suicide, hallucinations, muscular spasms.
At daily reception of Mezapamum for several weeks there can be a danger of development of mental and physical dependence (this disturbance can be observed both at reception of high doses of drug, and at its use in usual medical doses) in this connection continuation of therapy is possible only according to vital indications and only after a careful ratio of advantage of drug with risk of emergence of dependence on it. The risk of development of medicinal dependence increases at patients who abused ethanol or medicines earlier, and also at use of high doses, increase in duration of therapy.
Long use of Mezapamum by pregnant women can cause development of a withdrawal in the newborn. Reception of high doses of drug just before or at the time of delivery can cause a lowering of arterial pressure, respiratory depression, suction difficulty ("a syndrome of the sluggish child") and a hypothermia in the newborn.
In cases of the admission of reception of the next dose of Mezapamum, it needs to be accepted at once as soon as it was noticed, however it is impossible to double a single dose.
The use of alcoholic beverages during therapy is inadmissible.
During treatment and prevention of an abstinence syndrome it is necessary to cancel Mezapamum gradually.
In the period of an after-effect there can be serious conditions of excitement.
It is necessary to consider that tension or alarm connected with a daily stress, indications to purpose of anxiolytics usually are not.
Drivers of vehicles and patients, whose profession is connected with the increased concentration of attention, Mezapamum need to take with caution (in the first days of therapy it is recommended to refuse completely control of vehicles and the performance of work demanding bystry mental and physical reactions).
At simultaneous use of Mezapamum with some medicines the following effects can develop:
To store in the place, unavailable to children, at a temperature up to 30 °C.
Period of validity – 5 years.
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