Nazoferon

Nazoferon – drug with immunomodulatory, antimicrobic, antiviral and antiinflammatory action.

Form of release and structure

Nazoferon is issued in two dosage forms:

• Drops are nasal: colourless, transparent (on 5 ml in the glass bottles corked by droppers, on 1 bottle in a cardboard pack);
• Spray nasal: colourless, transparent (on 5 ml in the glass bottles closed by the pump doser, on 1 bottle in a cardboard pack complete with the sprayer of nasal appointment).

Nasal enters into structure of 1 ml of drops and spray:

• Active ingredient: alpha 2b recombinant interferon of the person – is not less than 100 000 IU (international units);
• Auxiliary components: a lysine hydrochloride, potassium chloride, эдетат dinatrium, a hydrochloride of a trometamol, трометамол, a gipromelloza, methylparahydroxybenzoate, water for injections.

Indications to use

Nazoferon appoint at treatment and prevention of acute respiratory viral infections and catarrhal diseases at patients of all age. Drug is used at long and frequent diseases of upper respiratory tracts, and also in the following situations:

• Contact with sick acute respiratory viral infections;
• Overcooling;
• Seasonal increase in incidence in organized collectives, adult and children's, in particular during the periods of epidemics (in group of the increased "risk" – health workers, teachers, tutors of kindergartens, etc.).

Contraindications

• Age till 1 year (spray nasal);
• Severe forms of allergic diseases (in the anamnesis);
• Hypersensitivity to drug components.

Route of administration and dosage

Therapy of acute respiratory viral infections should be begun at development of the first symptoms of a disease (for 5 days).

Usually appoint the following mode of dosing (frequency rate of use / a single dose (quantity of drops or spray doses in each nasal course) / a daily dose):

• Newborns and children till 1 year: drops – 5 times a day / 8000 ME (1 drop)/40 000 ME;
• Children of 1-3 years: drops – 3-4 times a day / 16 000 ME (2 drops) of/48 000-64 000 ME; spray – 3-4 times a day / 20 000 ME (the 2nd spray dose) of/60 000-80 000 ME;
• Children of 3-14 years: drops – 4-5 times a day / 16 000 ME (2 drops) of/64 000-80 000 ME; spray – 4-5 times a day / 20 000 ME (the 2nd spray dose) of/80 000-100 000 ME;
• Adults: drops – 5-6 times a day / 24 000 ME (3 drops) of/120 000-144 000 ME; spray – 5-6 times a day / 30 000 ME (the 3rd spray dose) of/150 000-180 000 ME.

At contact with patients and overcooling Nazoferon with the preventive purpose appoint 2 times a day according to an age dosage, course duration – 5-7 days. In case of need preventive courses can be repeated. At single contact with patients there is usually enough one vspryskivaniye or instillation.

At seasonal increase in incidence Nazoferon apply to prevention in the morning once according to an age dosage with an interval of 1-2 days.

Side effects

In isolated cases at Nazoferon's use there can be skin rash.

Special instructions

Before Nazoferon's use in the form of drops nasal it is necessary to accept a sitting position or lying on spin. At an instillation it is not necessary to touch internal walls of a nose with a bottle dropper. For hypodispersion of drops on a mucous membrane of a nose right after the procedure of several minutes it is necessary to mass nose wings fingers.

Spray nasal should be applied, being in vertical position. Before the first use it is necessary to activate the sprayer pressing.

At disturbance of marking and integrity of packaging, and also in cases of change of physical properties of Nazoferon (transparency or color), it is not necessary to use drug in any dosage form.

To avoid spread of an infection individual use of drug is recommended.

Medicinal interaction

At Nazoferon's use in uncomplicated cases additional symptomatic therapy (for example, paracetamol, streptocides, vasoconstrictive drops in a nose) is not required.

Simultaneous use of Nazoferon with intranasal vasoconstrictive drugs is not recommended as they can lead to emergence of a xeromycteria.

At the increased body temperature performing the combined treatment with antiinflammatory medicines is possible.

Terms and storage conditions

To store in protected from light, the place, unavailable to children, at a temperature of 2-8 °C.

Period of validity – 2 years.

Drops or spray after opening of a bottle can be used for 10 days on condition of storage of drug at a temperature of 2-8 °C (in the refrigerator).