Norbaktin

Norbaktin – antimicrobic drug of a broad spectrum of activity.

Form of release and structure

Dosage form – tablets, coated or a film cover: oval, with slanted edges, white or almost white color, on one party – risk, on another – the squeezed-out quadrangle in the middle of which the text of "NBT 400" is engraved (on 10 pieces in strips or blisters, in a cardboard pack 1, 2 or 3 strips/blisters).

Active agent: norfloxacin, contents in 1 tablet – 400 mg.

Additional components: croscarmellose sodium, starch corn, microcrystallic cellulose, magnesium stearate, silicon dioxide colloid, sodium the lauryl sulfate, talc purified.

Structure of a cover: a macrogoal 400, a gipromelloza, titanium the dioxide, talc purified the water purified.

Indications to use

Norbaktin – the medicine intended for treatment of the infectious diseases caused by microorganisms, sensitive to norfloxacin:

• Diarrhea of travelers;
• Uncomplicated gonococcal infection;
• Infections of an urinary system;
• Infections of generative organs;
• Infections of bodies of digestive tract.

Also drug is used for prevention of sepsis at patients with a neutropenia.

Contraindications

• The expressed renal failure (clearance of creatinine less than 10 ml/minute);
• Liver failure;
• Deficit glyukozo-6-fosfatdegidrogenazy;
• Disturbances of cerebral circulation;
• Atherosclerosis of vessels of a brain;
• Epilepsy, convulsive syndrome;
• Age up to 18 years;
• Period of pregnancy and lactation;
• Hypersensitivity to Norbaktin's components or other drugs of group of ftorkhinolon.

With care:

• Myasthenia;
• Disorders of the central nervous system;
• Dysfunction of kidneys/liver.

Route of administration and dosage

Norbaktin – drug for oral administration: it is necessary to swallow of tablets entirely and to wash down with a large amount of liquid. It is possible to reach the maximum therapeutic effect administration of drug on an empty stomach – in 1 hour prior to or in 2 hours after meal.

Doses and duration of treatment in each case are defined by the doctor depending on indications and weight of a course of a disease.

The average recommended doses:

• Acute uncomplicated cystitis: on 200-400 mg 2 times a day within 3-5 days;
• Other acute infections of an urinary system: on 400 mg 2 times a day within 7-10 days;
• Recurrent and chronic recurrent infectious diseases of an urinary system: on 400 mg 2 times a day within 4 weeks. In case of a recurrence – on 400 mg of 1 times a day;
• Infections of generative organs: on 400-600 mg 2 times a day for 7 days;
• Acute uncomplicated gonococcal infection: 800 mg once;
• Infectious diseases of digestive tract: on 400 mg 2-3 times a day a course of 3-5 days;
• Prevention of diarrhea of travelers in epidemic adverse areas: on 400 mg of 1 times a day, therapy duration – as necessary, but no more than 21 day;
• Prevention of sepsis at patients with a neutropenia: on 400 mg 3 times a day within 8 weeks.

Patients with a renal failure (clearance of creatinine less than 20 ml/minute or the level of serumal creatinine more than 5 mg / 100 ml) and the patient undergoing the procedure of clarification of blood (hemodialysis) should appoint on 1 full dose of 1 times a day or ½ therapeutic doses 2 times a day.

Side effects

• Allergic reactions: hypostases, urticaria, skin itch, Stephens-Johnson's syndrome;
• From the alimentary system: bitterness in a mouth, anorexia, diarrhea, nausea, vomiting, pain in an abdominal cavity, increase in activity of hepatic transaminases; at prolonged use – a pseudomembranous coloenteritis;
• From an urinary system: crystalluria, dysuria, albuminuria, polyuria, glomerulonephritis, giperkreatininemiya, urethral bleeding;
• From a nervous system: headache, dizziness, sleeplessness, hallucinations;
• From cardiovascular system: arrhythmias, tachycardia, vasculitis, faints, lowering of arterial pressure;
• From a musculoskeletal system: tendinitis, arthralgia, ruptures of sinews;
• From bodies of a hemopoiesis: increase in level of eosinophial blood cells, decrease in quantity of leukocytes in blood unit of volume, decrease in a hematocrit;
• Others: candidiasis.

Special instructions

For the prevention of development of a crystalluria during treatment it is recommended to drink a lot of liquid (under control of a diuresis).

It is necessary to consider that norfloxacin promotes increase in a prothrombin ratio. Patients should warn the doctor about Norbaktin's reception in need of an operative measure as during surgery it is necessary to control system of a blood coagulation.

During treatment it is necessary to avoid influence of direct sunshine, in connection with probability of development of dizziness – to be careful when driving the car and performing potentially dangerous types of the works requiring special attention and high speed of reactions.

At emergence of the first signs of an inflammation of a sinew of a muscle (tendovaginitis) or sinew pains it is necessary to cancel drug and to see a doctor for inspection.

Medicinal interaction

At the combined use with medicines which can promote a lowering of arterial pressure barbiturates or the anesthetizing drugs it is necessary to control the heart rate, arterial pressure and indicators of the electrocardiogram.

At simultaneous use of warfarin it is necessary to control coagulation indicators constantly.

Norfloxacin reduces clearance of theophylline (reduction of its dose is required) by 25%, increases plasma concentration of cyclosporine and indirect anticoagulants.

The antacids containing magnesium hydroxide or aluminum and also the drugs containing сукральфат zinc or iron, reduce norfloxacin absorption therefore between receptions of these means it is necessary to observe intervals not less than 4 hours.

Simultaneous use of medicines which can reduce a convulsive threshold is fraught with development of epileptiform spasms.

The norfloxacin applied during treatment by nitrofurans reduces their effect.

Terms and storage conditions

To store in the place, dry, unavailable to children, at a temperature up to 25 ºС.

Period of validity – 3 years.