Omnoponum

Omnoponum – narcotic opioid medicine of analgeziruyushchy action.

Form of release and structure

Solution for hypodermic (п / to) introductions of 1% or 2%: transparent liquid, light yellow or colourless (in ampoules on 1 ml, 5 ampoules in packagings planimetric cell, 1 or 2 packagings in a cardboard pack).

Active ingredients in 1 ml of solution 1%/2 of %:

• Morphine a hydrochloride – 5,75/11,5 mg;
• Narcotine – 2,7/5,4 mg;
• Codeine – 0,72/1,44 mg;
• Papaverine a hydrochloride – 0,36/0,72 mg;
• Tebaine – 0,05/0,1 mg.

Auxiliary components: эдетат dinatrium (disodium salt of ethylene diamine tetraacetic acid), глицерол (glycerin), acid solution hydrochloric 1M, water for injections.

Indications to use

Omnoponum is used at the expressed pain syndrome of various genesis chronic or acuity: injuries, posttraumatic pains, myocardial infarction, malignant new growths, preparation for surgical intervention, postoperative period, other similar states.

In a combination with atropinopodobny medicines or spasmolysants of myotropic action drug is used for stopping of a pain syndrome at renal, hepatic, intestinal gripes.

Contraindications

Absolute:

• Bronchial asthma;
• Chronic pulmonary heart;
• Heart arrhythmia;
• Simultaneous use with MAO inhibitors (monoamine oxidase) and for 2 weeks after their cancellation;
• The states/diseases which are followed by the expressed oppression of TsNS (central nervous system) or respiratory depression;
• Head injuries;
• The increased intracranial pressure;
• States after biliary tract operation;
• The acute diseases of abdominal organs demanding surgical intervention before establishment of the diagnosis;
• Paralytic Ilheus;
• Epilepsy and other convulsive states;
• Children's age up to 2 years;
• Hypersensitivity to Omnoponum components.

Relative (drug is used with care, in view of the increased probability of complications): advanced age, the general exhaustion, diseases of a liver and kidneys, the insufficiency of a bast layer of adrenal glands given in the anamnesis about opioid dependence.

During pregnancy, at childbirth and during a lactation (breastfeeding) Omnoponum is allowed for use only according to vital indications as the risk of development of medicinal dependence in the child is high.

Route of administration and dosage

Solution is entered subcutaneously.

The dose is selected individually and depends on a condition of the patient and expressiveness of a pain syndrome.

The recommended dose for adults – 10-20 mg (1 ml of 1% or 2% of solution); repeated administration of drug is in case of need allowed 4-5 hours later. The maximum single dose – 30 mg (1,5 ml of 2% of solution or 3 ml of 1% of solution). The maximum daily dose – 100 mg (5 ml of 2% of solution or 10 ml of 1% of solution).

To children Omnoponum is entered depending on required extent of anesthesia, the general state and age in a dose from 1 mg (2-3 years) to 7,5 mg (12-14 years).

Side effects

• Depression, euphoria, hallucinations, dizziness, excitement, drowsiness;
• Locks, nausea, are more rare vomiting (to reduce side effect by intestines it is recommended to accept laxative drugs);
• Spasms of a sphincter of a bladder, disturbance of an urination;
• Muscular weakness;
• Exacerbation of diseases of a brain owing to increase in intracranial pressure;
• Spasms of biliary tract;
• Moderate respiratory depression;
• Hypersensitivity reactions.

Owing to an injection there is an expansion of peripheral blood vessels to release of a histamine that can become the reason of a bronchospasm, hypotension, erubescence, strengthening of sweating, reddening of a fibrous casing of eyes.

In case of repeated use of solution for 1-2 weeks, and sometimes and 2-3 days, accustoming with easing of the anesthetizing effect and opioid medicinal dependence can develop. 1-2 days later after the termination of injections emergence of signs of a withdrawal is possible: headache, yawning, mydriasis, muscular contractions, hyperthermia, vomiting, diarrhea, perspiration, tachycardia, hypertensia, other vegetative symptoms. This state demands therapy in stationary specialized department.

Special instructions

Omnoponum causes accustoming, physical and mental opioid medicinal dependence.

In the course of treatment it is required to abstain from potentially dangerous types of activity demanding speed of psychomotor reactions and the increased concentration of attention including from control of motor transport.

Medicinal interaction

Omnoponum suppresses activity of a respiratory center and increases the oppressing influence on the central nervous system against the background of use of drugs for anesthesia, antidepressants, anti-psychotics and anxiolytics, and also sedative, hypnotic drugs and antihistamines of the central action. If use of Omnoponum in such combinations is necessary, it is necessary to accept the reduced doses and to carry out therapy under careful medical observation.

And agonists antagonists (буторфанол, налбуфин) opioid receptors it is not necessary to apply narcotic analgetics from group of partial agonists (трамадол, buprenorphine) along with Omnoponum because of the increased probability of weakening of an analgesia and a possibility of provoking of a withdrawal.

Opioid agonists (Promedolum, fentanyl) in case of use in therapeutic doses along with Omnoponum give cooperative analgesic effect, their side undesirable reactions are also summed up.

Terms and storage conditions

To store in the dark place unavailable to children, at a temperature up to 15 °C.

Period of validity – 3 years.