Oksamp

Oksamp – the combined antibiotic drug (semi-synthetic penicillin).

Form of release and structure

Oksamp release in the form of capsules (on 10 pieces in blister strip packagings, on 1 or 2 packagings in a cardboard pack; on 20 pieces in banks, after 1 bank in a cardboard pack).

Active agents are a part of 1 capsule:

• Ampicillin – 125 mg (in the form of ampicillin trihydrate);
• Oxacillinum – 125 mg (in the form of sodium Oxacillinum).

Auxiliary components: potato starch, icing sugar (sucrose).

Structure of a gelatin capsule: пропилпарагидроксибензоат, gelatin, titanium dioxide, methylparahydroxybenzoate, acetic acid.

Indications to use

Oksamp appoint for treatment of the infectious and inflammatory diseases caused by the microorganisms showing sensitivity to effect of active agents:

• Infections of soft tissues and skin, including impetigo, an ugly face for the second time infected a dermatosis;
• Cholecystitis, cholangitis;
• Tonsillitis, sinusitis, average otitis;
• Gonorrhea, pyelonephritis, cystitis, pyelitis, urethritis, cervicitis;
• Bronchitis, pneumonia.

Contraindications

• Lymphoid leukosis;
• Infectious mononucleosis;
• Age up to 3 years;
• Hypersensitivity to drug components.

To pregnant women Oksamp appoint only after an advantage ratio with risk for health of mother and the child. In the period of a lactation in cases of need of administration of drug breastfeeding is recommended to be interrupted.

Route of administration and dosage

Oksamp accept inside.

The recommended dosing mode (the specified dosages are the sum of doses of two active ingredients in the fixed proportion 1:1):

• Adults and children of 14 years: a single dose – 0,5-1 g, daily – 2-4 g;
• Children of 7-14 years: a daily dose – 0,05 g/kg (in 4-6 receptions);
• Children of 3-7 years: a daily dose – 0,1 g/kg (in 4-6 receptions).

Duration of a medical course can vary from 5-7 to 14 days.

Side effects

• Hemopoietic system: neutropenia, leukopenia, anemia;
• Alimentary system: taste change, dysbacteriosis, vomiting, diarrhea, nausea; seldom – a pseudomembranous coloenteritis;
• Allergic reactions: dermahemia, urticaria, rhinitis, Quincke's disease, conjunctivitis, arthralgia, fever, eosinophilia; seldom – an acute anaphylaxis;
• Others: superinfection.

Special instructions

At patients with a renal failure when performing therapy using high doses of Oksamp perhaps toxic action on the central nervous system.

When carrying out a long course of therapy it is necessary to control a functional condition of bodies of a hemopoiesis, kidneys and a liver.

At probability of development of superinfection (it is connected with growth of microflora, insensitive to it) carrying out corresponding change of antibacterial treatment is required.

With hypersensitivity to penicillin development of cross allergic reactions with antibiotics of group of cephalosporins is possible.

If during administration of drug there are symptoms of an acute anaphylaxis, it is necessary to take the urgent measures for removal of the patient from this state including introduction of Epinephrinum, antihistaminic drugs and glucocorticosteroids if necessary it is necessary to carry out artificial ventilation of the lungs.

Medicinal interaction

At combined use of Oksamp with some drugs there can be following effects:

• Glycosamine, antacids, laxative drugs, food, aminoglycosides (enteral introduction): delay and decrease in absorption of Oksamp;
• Bactericidal antibiotics (including rifampicin, cephalosporins, aminoglycosides, Vancomycinum): action potentiation;
• Bacteriostatic drugs (tetracyclines, chloramphenicol, macroleads, linkozamida, streptocides): antagonistic action;
• Indirect anticoagulants: increase in their efficiency, and also suppression of intestinal microflora, decrease in synthesis of vitamin K and prothrombin ratio;
• Ascorbic acid: increase in absorption of Oksamp;
• Oral contraceptives, ethinylestradiol, medicines in the course of which metabolism paraaminobenzoic acid is formed: reduction of their efficiency;
• Allopyrinolum: increase in probability of development of skin rash;
• Blockers of canalicular secretion, diuretics, phenylbutazone, Allopyrinolum, the nonsteroid antiinflammatory medicines and other drugs blocking canalicular secretion: increase in concentration of Oksamp in plasma that increases probability of development of toxic action.

Terms and storage conditions

To store in protected from light, the place, dry, unavailable to children, at a temperature up to 20 °C.

Period of validity – 2 years.