Pantsef

Pantsef – the parenteral tsefalosporinovy antibiotic medicine of the third generation applied to treatment of various infectious diseases.

Pharmacological action of Pantsef

Active component of Pantsef works bakteritsidno and, breaking synthesis of a cell wall of bacteria, influences different types of microorganisms (anaerobic and aerobic gram-positive and gram-negative).

Release form

Pantsef release in a look:

• Film coated tablets with the content of active agent (tsefiksim) in number of 400 mg;
• Light yellow granules for preparation of suspension for intake in bottles on 60 ml and 100 ml. The suspension prepared from granules has white-yellowish color and an orange smell.

Pantsef's analogs

On active component Pantsef's analogs are medicines Supraks, Iksim Lyupin, Tsemideksor, Tseforal Solyutab and Supraks Solyutab.

On the action mechanism treat Pantsef's analogs: Azawounds, Rotsefin, Dardum, Bestum, Biotrakson, Medakson, Movigip, Axon, Rezibelakta, Lendatsin, Orzid, Lorakson, Vitsef, Kefoteks, Sulperazon, Klaforan, Movoperiz, Sulmover, Liforan, Operaz, Oritaksim, Sultsefazon, Tizim, Fortum, Tsedeks, Fortazim, Tsefantral, Tsefobid and Tsefoperus.

Indications to Pantsef's use

Pantsef according to the instruction it is necessary to appoint at treatment:

• Uncomplicated infections of urinary tract;
• Bacterial infections of upper and lower respiratory tracts, namely: pharyngitis, sinusitis, tonsillitis, acute bronchitis and exacerbations of chronic bronchitis;
• Uncomplicated gonorrhea of a neck of uterus and urethra;
• Average otitis.

Contraindications

Pantsef do not appoint in the following cases:

• Against the background of hypersensitivity to active (tsefiksy) or auxiliary components of medicine, and also to Penicillaminum and penicillin;
• At pregnancy;
• During breastfeeding.

Pantsef do not apply to children before achievement of six-months age.

With care appoint Pantsef according to the instruction to people of advanced age, against the background of a renal failure and at colitis in the anamnesis.

Pantsef route of administration

Pantsef for children of 12 years (more than 50 kg) and adults appoint 400 mg once a day. It is also possible to divide a daily dosage of medicine into two receptions.

Pantsef for children to 50 kg appoint in the form of suspension proceeding from the mass of their body – from three to nine mg to 1 kg of weight (but no more than 12 mg/kg).

The average duration of therapy by Pantsef – 7-10 days. At the diseases caused by Streptococcus pyogenes, therapy usually more long (not less than 10 days), at treatment of uncomplicated gonorrhea of a neck of uterus and urethra accept once 400 mg of a medicine.

At a renal failure the dose is reduced by 25-50%.

Side effects of Pantsef

Pantsef, according to reviews, can lead to disturbances of some systems of an organism. During therapy development is the most probable:

• Vaginitis (urinogenital system);
• Headache, sonitus, dizzinesses (nervous system);
• Abdominal pains, nausea, stomatitis, vomiting, diarrhea, pseudomembranous colitis, dysbacteriosis, locks, cholestasia (alimentary system);
• Renal failures and intersticial nephrite (urinary system);
• Bleedings, leukopenia, pancytopenia, agranulocytosis, neutropenia, aplastic and hemolitic anemia, thrombocytopenia (bodies of a hemopoiesis).

The allergic reactions most often accompanying therapy by Pantsef according to reviews are shown as:

• Multiformny exudative erythema;
• Eosinophilia;
• Small tortoiseshell;
• Skin itch;
• Dermahemia;
• Fever;
• Itch in the field of generative organs;
• Toxic epidermal necrolysis.

Among other disturbances which are caused by Pantsef according to reviews the hyperbilirubinemia, a candidiasis, increase in an urea nitrogen, development of a hypovitaminosis In, a giperkreatininemiya, an asthma is observed.

At overdose by medicine the described side effects, as a rule, amplify.

Also before an initiation of treatment Pantsef it is necessary to consider that against the background of allergic reactions to penicillin in the anamnesis hypersensitivity to tsefalosporinovy antibiotics can be shown.

Medicinal interaction

According to the instruction leads simultaneous use of a medicine with blockers of canalicular secretion to increase in toxicity of Pantsef, including Allopyrinolum and diuretics.

Also during therapy it is necessary to consider that Pantsef strengthens effect of indirect anticoagulants, and antacids which part are magnesium or aluminum hydroxide promote delay of absorption of medicine and reduce its therapeutic effect.

Storage conditions

Pantsef is among the parenteral tsefalosporinovy antibiotics which are released according to the recipe with a period of validity 3 years at observance of standard storage conditions. It is necessary to store the suspension prepared from granules no more than two weeks at a temperature of 15-25 degrees Celsius.