Pefloksatsin

Pefloksatsin – antimicrobic medicine of a wide range of bactericidal action, group of ftorkhinolon.

Form of release and structure

Dosage forms of drug:

• Tablets, coated (on 10 pieces in the blister, in a cardboard box 1 blister);
• Solution for infusions (on 100 ml in bottles, in a cardboard box 1 bottle, for hospitals – in a cardboard box of 48 bottles).

Content of active ingredient:

• 1 tablet: пефлоксацин, in the form of Methansulfonas natricum – 400 mg;
• 1 ml of solution: пефлоксацин, in the form of a mezilat of a dihydrate (in terms of пефлоксацин) – 4 mg.

Indications to use

Use of drug is shown at treatment of the caused by the microorganisms sensitive to a pefloksatsin, infections and inflammatory processes of the following localization:

• Gepatobiliarny system (liver, gall bladder and biliary tract);
• Bones and joints;
• ENT organs (ear, throat, nose) and lower parts of respiratory tracts;
• Urinary system (kidneys and urinary tract);
• Abdominal cavity and bodies of a small pelvis;
• The alimentary system (including infection of a mouth, jaws, teeth);
• Skin, soft tissues, mucous membranes;
• Gynecologic infections, diseases, sexually transmitted (clamidiosis, gonorrhea), prostatitis;
• Intrahospital and surgical infections;
• Heavy system infections (bacteremia, septicaemia, endocarditis, osteomyelitis, encephalomeningitis).

Besides, solution is appointed for prevention and treatment of infectious complications after carrying out surgeries.

Contraindications

• Deficit glyukozo-6-fosfatdegidrogenazy;
• Period of pregnancy and breastfeeding;
• Age up to 15 years;
• Hypersensitivity to a pefloksatsin and other ftorkhinolona.

Besides, purpose of tablets is contraindicated to patients with a liver failure.

With care appoint solution to patients with heavy abnormal liver functions, disturbances of cerebral circulation, atherosclerosis of vessels of a brain, a convulsive syndrome of unspecified genesis, epilepsy.

Route of administration and dosage

Tablets, coated
Pill is taken inside, swallowing entirely, during food.

The recommended dosing: on 400 mg twice a day (in the morning and in the evening).

In the absence of desirable therapeutic effect increase in a daily dose up to 1600 mg is shown.

Solution for infusions
Solution is intended for intravenous drop administration.

The doctor appoints a dose on the basis of clinical indications individually, taking into account weight of a current and localization of an infection, and also sensitivity of a microorganism to drug.

The recommended dosing mode:

• Severe forms of infectious diseases: an initial dose – 800 mg, further – on 400 mg 2 times a day every 12 hours. The patient with a renal failure appoint 400 mg, at an easy form of pathology – 1 time at 24 o'clock, at heavy – with an interval between procedures at 36 o'clock;
• Liver infections: from calculation for 8 mg on 1 kg of body weight of the patient lasting infusion of 1 hour. Frequency of procedures: at jaundice – 1 time at 24 o'clock, ascites – 1 time at 36 o'clock, the patient with jaundice and ascites – 1 time at 48 o'clock.

The daily dose of Pefloksatsin should not exceed 1200 mg.

Side effects

• Alimentary system: nausea, abdominal pains;
• Musculoskeletal system: arthralgia, mialgiya;
• Nervous system: sleeplessness, headache;
• System of a hemopoiesis: thrombocytopenia (at a daily dose of 1600 mg);
• Dermatological reactions: photosensitization.

Besides, Pefloksatsin's use can become the reason of the following side reactions:

• Tablets, coated: dizziness, dispeptic phenomena;
• Solution for infusions: vomiting, diarrhea, development of allergic reactions in the form of a small tortoiseshell, a skin itch.

Special instructions

During Pefloksatsin's use the patient should avoid influence of ultraviolet radiation.

For prevention of development of resistance of bacteria to a beta laktamnym to antibiotics and rifampicin solution is appointed as a part of a combination therapy.

Medicinal interaction

At simultaneous use with pefloksatsiny:

• Aminoglycosides – promote a synergism to a pyocyanic stick;
• Indirect anticoagulants – can strengthen the action;
• Cimetidinum – leads to increase ^{in T1/2} of a pefloksatsin and decrease in the general clearance;
• Theophylline – slows down the metabolism in a liver and increases concentration in a blood plasma;
• The antacids containing magnesium hydroxide and aluminum hydroxide – slow down absorption of a pefloksatsin.

Solution for infusions cannot be mixed with the drugs containing chlorine ions.

Terms and storage conditions

To protect from children. To store in the protected from light, dry, cool place. Solution storage temperature – 10-25 °C (not to freeze).

Period of validity: tablets – 3 years; solution – 2 years.