Perftoran

Perftoran – a blood substitute with gas transmission function.

Form of release and structure

Dosage form – an emulsion for intravenous (in/in) introductions: after defrosting – transparent, with a bluish shade, inodorous (on 50, 100, 200 or 400 ml in the glass bottles with rubber covers which are pressed out by aluminum caps).

In 100 ml of an emulsion the following active agents contain:

• Pfokalin – 13 g;
• Pforidin – 6,5 g;
• Proksanol – 4 g;
• Sodium chloride – 0,6 g;
• Glucose – 0,2 g;
• Natrii hydrocarbonas – 0,065 g;
• Potassium chloride – 0,039 g;
• Sodium phosphate monosubstituted – 0,02 g;
• Magnesium chloride (in terms of dry matter) – 0,019 g.

As excipient water for injections is used (to 100 ml).

Indications to use

• Acute and chronic hypovolemia (in the operational and postoperative period, at infectious and toxic, hemorrhagic, traumatic and burn shock, a craniocereberal injury);
• Disturbances of peripheric circulation and microcirculation (at changes of gas exchange and fabric metabolism, infections, a fatty embolism, disturbances of cerebral circulation, it is purulent - septic states);
• Lavage of lungs, partial perfusion, washing of purulent wounds belly and other cavities;
• Antiischemic protection of donor organs (preliminary training of the recipient and donor).

Contraindications

The only strict contraindication to Perftoran's use is hemophilia.

With care and only according to vital indications drug is used during pregnancy and a lactation.

Route of administration and dosage

Before drug injection the doctor performs visual inspection of an emulsion and bottle. Perftoran is considered suitable for use on condition of preservation of tightness of packing, lack of cracks on a bottle and safety of the label. The result of visual survey and data specified on the label (the name of medicine, the manufacturing enterprise and number of a series) are registered in the history of a disease.

Before an initiation of treatment carry surely out a bioassey: slowly enter to the patient of 5 drops of an emulsion, then do a 3-minute break then enter 30 more drops and again do a break for 3 minutes. If negative reactions do not arise, continue introduction. Results of a bioassey also register in the history of a disease.

The recommended schemes of use of Perftoran:

• Disturbances of microcirculation regardless of genesis: on 5-8 ml/kg. If necessary the drug is administered in the same dose by 3 times with 2-4 day intervals. For increase in oksigenatsionny effect supply of the air mixture enriched with oxygen is recommended (through a mask or a nasal catheter);
• Acute blood loss, shock: in a dose of 5-30 ml/kg in/in kapelno or struyno. It is possible to gain the maximum effect of drug in cases when the patient breathes the mix enriched with oxygen – directly during infusion and within a day after it;
• Antiischemic protection of donor organs: in a dose of 20 ml/kg in/in struyno or kapelno to both the recipient, and the donor in 2 hours prior to carrying out operation;
• Topical administration: according to the scheme similar to use of traditional means of medicamentous therapy;
• Regional use (perfusion of extremities): on 40 ml/kg when filling the standard oxygenator.

Side effects

Pains behind a breast and in lumbar area, allergic reactions (a skin itch, a small tortoiseshell and reddening of integuments), anaphylactoid reactions, breath difficulty, increase of pulse, a headache, temperature increase, a lowering of arterial pressure are possible.

Special instructions

Perftoran is intended for use only in hospitals.

Drug cannot be used if after defrosting the white deposit at the bottom of a bottle appears or the emulsion is stratified (the transparent oily drops settling on a bottom even after agitation are visible).

It is forbidden:

• To store drug at a temperature below-18 ºС;
• To defreeze at a temperature more than 30 ºС;
• It is strong to shake the defrozen emulsion.

In case of development of side effects or complications it is necessary to stop immediately Perftoran's introduction and, without taking out from a needle vein, depending on the overall clinical picture to enter the glucocorticosteroid, cardiotonic, angiotonic, desensibilizing or other drugs intended for therapy of an acute anaphylaxis.

It is necessary to defreeze Perftoran at the room temperature then carefully to stir up before achievement of uniformity of structure. Before infusion the emulsion needs to be warmed up to the temperature of 21-23 ºС.

Medicinal interaction

Perftoran it is forbidden to apply together (in one cardiopulmonary bypass, one system or the syringe) with oxyethylstarch, dextrans, reopoliglyukiny, Polyglucinum. In need of simultaneous use with the specified means they should be entered into other vein or into the same, but after the end of infusion of Perftoran.

Terms and storage conditions

To store at a temperature from-4 to-18 ºС (in the frozen look).

Period of validity – 3 years.

Also perhaps temporary storage of drug in the defrozen look – at a temperature of 4 ºС no more than 2 weeks.

5-fold defrosting / freezing is allowed.