Pyrantelum

Pyrantelum – protivogelmintny broad-spectrum agent. Has effect on puberal and immature individuals of both floors, does not affect larvae in a migration stage.

Form of release and structure

• Tablets: an oval form, biconvex, yellow color, with risky on one of the parties (on 3 pieces in blisters or strips from aluminum foil, in a pack the cardboard 1 blister or 1 strip);
• Suspension for intake: a homogeneous consistence, yellow color (on 15 ml in dark glass bottles, in a pack a cardboard 1 bottle and a measured cap).

Active agent: Pyrantelum (in the form of a pamoat), its contents in 1 tablet and 5 ml of suspension makes 250 mg.

Auxiliary components of tablets: the gelatin, corn starch, talc purified sodium carboxymethylstarch, magnesium stearate.

Additional components of suspension: polysorbate 80, xanthane gum, sucrose, sorbic acid, propylparaben, sorbitol of 70% solution, methylparaben, the water purified chocolate S 2761 fragrance (water, propylene glycol, dye caramel and aromatic substances (natural, artificial and identical to natural)), ice cream fragrance (water, propylene glycol, dye caramel, and aromatic substances (natural, artificial and identical to natural)).

Indications to use

• Necatoriasis;
• Ascaridosis;
• Trichuriasis;
• Enterobiosis;
• Dochmiasis.

Contraindications

Absolute:

• Period of treatment of a myasthenia;
• Children's age up to 3 years – for tablets;
• Lactation (or feeding should be interrupted);
• Hypersensitivity to drug components.

Relative:

• Liver failure;
• Children's age up to 6 months – for suspension.

During pregnancy medicine is appointed only after careful assessment of estimated advantage and possible risks.

Route of administration and dosage

Pyrantelum should be accepted inside in time or after food, – carefully to chew a tablet.

At an ascaridosis, an enterobiosis and the mixed invasions adult appoint 10 mg/kg once: adults and children are more senior than 12 years – 750 mg (3 tablets or 15 ml of suspension), patients with body weight more than 75 kg – 1000 mg (4 tablets or 20 ml of suspension).

To children depending on age appoint:

• From 6 months to 3 years – 125 mg (2,5 ml of suspension);
• Children of 3-6 years – 250 mg (1 tablet or 5 ml of suspension);
• Children of 6-12 years – 500 mg (2 tablets or 10 ml of suspension).

At a dochmiasis, an ascaridosis combination to a necatoriasis and other combined helminthoses appoint on 10 mg/kg/days within 3 days or on 20 mg/kg/days for 2 days.

At the isolated ascaridosis the recommended dose makes 5 mg/kg once.

In order to avoid a self-invasion in 3 weeks after the first administration of drug carrying out a repeated course is recommended.

Side effects

• From the alimentary system: stomach aches, loss of appetite, diarrhea, nausea, vomiting; in rare instances – increase in activity of hepatic transaminases;
• From the central nervous system: seldom – weakness, drowsiness or sleeplessness, dizziness, a headache; in individual cases – confusion of consciousness, a hallucination, paresthesia, a hearing disorder;
• Others: fervescence, rash on skin, a small tortoiseshell.

Special instructions

Laxative after reception of Pyrantelum should not be accepted.

At an enterobiosis all have to undergo treatment at the same time jointly the living persons.

Prevention of reinfection requires the careful respect for hygiene including cleaning of clothes and cleaning of premises.

After the end of treatment carrying out a control research a calla on existence of eggs of parasites is necessary.

Information on influence of Pyrantelum on the speed of reactions and ability to concentration of attention is absent.

Medicinal interaction

Pyrantelum promotes increase in concentration of theophylline in a blood plasma.

It is not recommended to use drug along with piperazin as Pyrantelum at such combination works antagonistic.

Terms and storage conditions

To store at a temperature up to 25 ºС in the place protected from moisture and light unavailable to children.

Period of validity – 3 years.