Fish oil

Fish oil – the complex of vitamins of animal origin promoting regulation of lipidic exchange.

Form of release and structure

Dosage forms of production of Fish oil:

• capsules on 500 mg: transparent, elastic, soft gelatinous, oval, with a seam, light yellow; contents of capsules – oily transparent liquid from yellow till light yellow color, has a slight specific, not rancid smell (on 10 pieces in blister strip packagings (polyvinylchloride/aluminium), on 5, 7 or 10 packagings in a cardboard pack);
• capsules on 250/300/500/800 mg (dietary supplement to food (dietary supplement)) (in packagings or packages on 100 pieces).

Structure of 1 capsule:

• active agent: the vitaminized fish oil – 500 mg (vitamin A – 500 IU (international units), vitamin D – 50 ME, dokozageksayenovy acid – is not less than 9%, eykozapentayenovy acid – is not less than 8%, PNZhK (polyunsaturated fatty acids) – it is not less than 20%);
• cover of capsules: пропилпарагидроксибензоат – 0,07 mg, methylparahydroxybenzoate – 0,28 mg, глицерол – 62,92 mg, gelatin – 136,13 mg, the purified water – 17,6 mg.

Active agents as a part of 1 capsule (dietary supplement) 300/500/800 of mg:

• fat of ocean fishes (PNZhK an omega-3) – 90/150/240 mg;
• alpha tocopherol acetate (vitamin E) – 1,5/2,5/4 mg.

Auxiliary components (dietary supplements): gelatin, glycerin.

Indications to use

• prevention of hypovitaminoses of A and D (drug);
• additional source of PNZhK omega-3 (dokozageksayenovy, eykozapentayenovy acids) and vitamin E (dietary supplement).

Contraindications

Drug
Absolute:

• zhelchekamenny disease;
• long immobilization (in high doses);
• urolithiasis;
• chronic pancreatitis;
• thyrotoxicosis;
• hypercalcuria;
• idiopathic hypercalcemia;
• diseases of livers/kidneys (in an acute and chronic current);
• hypervitaminosis of A and D;
• pulmonary tuberculosis (in an active form);
• inflammatory diseases of skin in an acute current;
• sarcoidosis and other granulomatoses;
• age up to 7 years;
• pregnancy and period of a lactation;
• hypersensitivity to drug components.

Relative (Fish oil is appointed with care in the presence of the following diseases / states):

• hypothyroidism;
• alcoholism;
• organic lesions of heart;
• peptic ulcer of a stomach and duodenum;
• heart failure of the II-III stage;
• atherosclerosis;
• advanced age.

Dietary supplement to food is contraindicated at hypersensitivity to drug components.

Route of administration and dosage

Drug
Fish oil is accepted inside, washing down with warmish or cold water, it is more preferable – after meal. It is recommended to swallow capsules at once, without detaining for a long time in a mouth.

Single dose – 1-2 capsules, frequency rate of reception – 3 times a day.

The recommended duration of a course of administration of drug – 1 month.

Dietary supplement to food
Fish oil is accepted inside, it is more preferable – along with meal.

The recommended dosing mode:

• 3-7 years – 3 times a day on 1 capsule of 300 mg;
• 7-14 years – 3 times a day on 2 capsules of 300 mg or 1 capsule of 500 mg;
• adults and teenagers of 14 years – 3 times a day on 3 capsules 300 mg, or 2 times a day on 2 capsules 500 mg, or 2 times a day on 1 capsule of 800 mg.

The recommended dietary supplement reception course duration – 1 month. The doctor can appoint a repeated course.

Side effects

At use of Fish oil in the recommended doses side reactions, as a rule, do not arise.

Development of allergic reactions and decrease in coagulability of blood is possible.

Special instructions

Drug
To avoid overdoses, the combined use with drugs with the content of vitamins A and it is not recommended to D.

Carrying out long courses with reception of high doses can lead to development of a chronic hypervitaminosis. In cases of use of Fish oil for the purpose of prevention it is necessary to consider that the overdose, in particular at patients of children's age can develop.

The need for vitamin D for advanced age can increase.

Dietary supplement to food
Before use of Fish oil, and also in cases of development of uncharacteristic symptoms it is necessary to consult at the specialist (to children – at the pediatrician).

Medicinal interaction

At the combined use of Fish oil with some medicinal means / substances development of the following effects is possible:

• anticonvulsants, barbiturates: vitamin D decrease of the activity;
• estrogen: increase in probability of a hypervitaminosis And;
• glucocorticoids: decrease in their antiinflammatory action (at the expense of vitamin A);
• calcium drugs, benzodiazepines: easing of their effects, increase in probability of development of a hypercalcemia;
• Neomycinum, Colestyraminum, mineral oils, колестипол: vitamin A absorption reduction;
• изотретиноин: increase in probability of development of toxic effect;
• tetracycline (with high (from 50 thousand. Piece) vitamin A doses): increase in probability of development of intracranial hypertensia;
• vitamin E (in high doses): decrease in reserves of vitamin A;
• cardiac glycosides: strengthening of their action and increase in risk of developing of arrhythmia;
• barbiturates (including phenobarbital), Phenytoinum, Primidonum: significant increase in need for vitamin D;
• aluminum - and magniysoderzhashchy antacids (long therapy): increase in concentration in blood of vitamins A and D;
• phosphorus drugs: increase in their absorption and probability of emergence of a hyperphosphatemia;
• glucocorticosteroids, rifampicin, calcitonin, isoniazid, bisfosfonata, пликамицин: decrease in efficiency of Fish oil.

At the combined use the interval between administration of drugs has to make:

• sodium fluoride – is not less than 2 hours;
• peroral forms of tetracyclines – it is not less than 3 hours.

Terms and storage conditions

To store in protected from light, the place, dry, unavailable to children, at a temperature up to 25 °C.

Period of validity – 2 years.