Application instruction:
Sandostatin – the drug which is applied in gastroenterology.
Sandostatin is synthetic derivative hormone of somatostatin under the influence of which the development of a growth hormone caused by an insulin hypoglycemia, exercise stresses and arginine is suppressed; the production of gastrin, a glucagon, insulin caused meal or arginine; production of thyrotropin – hypophysis hormone.
Solution for pricks.
Sandostatin apply to treatment of an acromegalia – a disease at which the disproportional growth of internals, fabrics, a skeleton is observed. Sandostatin to people with this pathology appoint when treatment by radiation therapy, surgical intervention, reception of antagonists of a dopamine did not bring result. Sandostatin's use gives the chance to control displays of a disease and the level of decrease in somatomedin and the growth hormone (GH).
In Sandostatin's instruction it is specified also that it is possible to appoint him in the presence of endocrine new growths in a GIT or a pancreas – he reduces expressiveness of symptoms; at gastrinoma, Vipomakh, carcinoid tumors, glucagonomas, insulinoma, somatoliberinoma; at refractory diarrhea at those who have AIDS.
Sandostatin is also effective when it is necessary to stop, or to prevent bleeding from expanded veins of a stomach or a gullet at patients with cirrhosis, and also after carrying out operation on a pancreas – for the prevention of development of complications.
To patients with an acromegalia in an initiation of treatment enter 0,05-0,1 mg of Sandostatin subcutaneously each 8 or 12 hours. Carry monthly out analyses on the maintenance of a growth hormone, analyze a clinical picture and depending on the obtained data the dosage can be increased to 0,2-0,3 mg. More than 1,5 mg a day are not recommended to be accepted to the patient. According to Sandostatin's instruction treatment needs to be stopped if in three months sufficient decrease in the GR level and improvement of a state is not noticed.
To patients with endocrine tumors of a pancreas and GIT enter 0,05-0,1 mg of drug a day.
For treatment of refractory diarrhea at those who have AIDS appoint 0,3 mg of Sandostatin. If in a week the state does not improve, the dosage can be raised to 0,75 mg. Treatment is stopped if also this dosage in a week of use does not bring result.
For the prevention of development of complications after pancreas operation Sandostatin enter in a dosage 0,3 mg a day.
For a bleeding stop from veins of a stomach or a gullet carry out intravenous infusion – enter 25 mkg/h for five days.
Sandostatin can cause anorexia, abdominal distention, a liquid chair, spasms in a stomach, nausea, pancreatitis, acute intestinal impassability (seldom).
Because of prolonged use of Sandostatin stones in a gall bladder can appear, develop a hyperglycemia.
The possibility of emergence of local reactions in an injection site of Sandostatin under skin is not excluded – it can be pain, burning, a swelling, reddening, an itch. There pass similar symptoms usually within 15 minutes.
In Sandostatin's instruction it is specified that he is contraindicated at hypersensitivity, during breastfeeding, pregnancy.
Patients with diabetes and a cholelithiasis should take medicine with caution.
Name of drug
Price
Drugstore
Sandostatin solution for инъ 50 mkg 1 ml No. 5, Novartis Pharma
1166 rub.
Sandostatin solution for инъ 100 mkg 1 ml No. 5, Novartis Pharma
1987 rub.
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