Семакс

Pharmacological action

Семакс – (метионил-глутамил-гистидил-фенилаланил-пролил-глицил-пролин) – is a synthetic analog of corticotropin and belongs to the class of regulatory peptides, has nootropic properties, has psychogogic, anti-hypoxemic and antioxidant effect, at the same time it is deprived of hormonal activity.

Effect of drug of Semaks is directed to the processes connected with memory: strengthens attention during the storing and the analysis of information, improves the organization of structures of memory. Семакс helps an organism to adapt to a hypoxia, an anesthesia, cerebral ischemia and other influences, destructive for a brain.

Semaks's use is not toxic as single, and for a long time. Practical reviews of Semaksa show that drug does not reveal allergic, teratogenic and mutagen properties.

Семакс it is entered in the list of the vital medicines approved by the government of Russia.

Release form

Is issued in the form of colourless nasal drops of 0,1%.

Pharmacokinetics

Drug gets through a mucous membrane of a nasal cavity. It is acquired approximately for 60-70% of active agent. Quicker than other analogs of Semaks, extends on all organism. Getting to blood, rather actively degrades, breaking up to separate amino acids, and it is brought out of an organism with urine.

Indications to Semaks's use

The intellectual disturbances connected with vascular damages of a brain, effects of craniocereberal injuries, neurosurgical interventions. Strokes, including ostroishemichesky, migraine, recovery after the frustration caused by an anesthesia, asthenoneurotic syndromes of the different nature. Chronic disturbances of cerebral circulation.

Besides, recommend Semaks for use for increase in adaptation opportunities of a brain in extreme situations, prevention of overfatigue, work-related in emergency situations, especially during the monotonous work.

Before use of drug it is recommended to study attentively the instruction to Semaks.

Route of administration and dosage

Семакс it is applied intranazalno, by means of the bottle supplied with a pipette. The detailed scheme contains in the instruction to Semaks. One drop of solution contains 50 mkg of active agent. By means of a pipette solution is entered into the nasal canal. If necessary perhaps additional use with an interval of 10-15 minutes. The single dose is calculated 3-30¼¬ú/kg, daily 7-70 mkg/kg. The standard course makes from a week to 10 days.

Side effects of Semaks

Семакс, being drug from group of regulatory peptides, it is applied in small doses (usually the tenth shares of mg). The left doctors applying Semaks responses showed its high performance and the safety of reception connected with it

Also lack of negative interaction with other drugs, including ethylcontaining was established.

Contraindications

Hypersensitivity or individual intolerance to drug components. Acute mental disorders, spasms.

Semaks's use at pregnancy and a lactation

The result of experiments did not reveal any teratogenic or toxic influences on a fruit, but serious clinical tests was not carried out. Therefore to use drug at pregnancy or a lactation it is possible only in case the expected advantage for mother exceeds possible harm for a fruit or future child. Or it is worth applying Semaks's analogs which passed clinical tests.

Side effects of Semaks

Among side effects of drug the irritation of a mucous membrane of a nose, possible at prolonged use, which is easy for stopping is established, having cancelled Semaks's use for couple of days, or having appointed additional use of drops on an oil basis.

Signs of overdose of drug were not revealed, even at essential increase in a single dose.

Storage

It is necessary to store drug of Semaks in the place unavailable to children protected from light, at a temperature from +1 to + 10C.