Sydnopharmum

Sydnopharmum – the pharmacological drug from group of vasodilators used for prevention of attacks of stenocardia.

Structure and form of release

According to the instruction Sydnopharmum is issued in the form of tablets on 2 mg. Active ingredient – Molsidominum. Also auxiliary components are a part: wheat starch, lactose, colloid silicon dioxide, magnesium stearate, gidroksipropilmetiltsellyuloza, mint oil, microcrystallic cellulose.

Externally Sydnopharmum represents round tablets of light pink color, convex from two parties, with a pleasant mint smell. Drug in blisters on 10 tablets is produced. In cardboard packaging 3 blisters together with the instruction.

Pharmacological action of Sydnopharmum

According to the instruction Sydnopharmum has the vasodilating (vasodilating) effect. Drug renders anti-anginal, antiagregantny, venodilatiruyushchy and analgeziruyushchy action. Action of metabolites of Sydnopharmum is resulted by relaxation of smooth muscle fibers of a vascular wall (preferential veins), result of what preload of heart decreases. Drug also broadens the narrowed sites of coronary arteries and improves collateral blood supply of a myocardium. Use of Sydnopharmum increases portability of loadings, reduces the frequency of attacks of stenocardia (which arise at an exercise stress).

According to the instruction Sydnopharmum interferes with early aggregation of thrombocytes, reduces release of serotonin, thromboxane and other proagregant.

Action of Sydnopharmum begins approximately in 20 minutes after its intake, and reaches a maximum in 1 hour. Duration of effect of drug about 6 hours. Prolonged use of Sydnopharmum does not cause development of tolerance with reduction of efficiency of drug (unlike nitrates).

Drug generally is removed by kidneys (90%). Elimination half-life about 2-2,5 hours.

Sydnopharmum at long use does not kumulirutsya in an organism, even at patients with a renal failure.

Indications to use

According to the instruction Sydnopharmum is recommended for prevention of attacks of stenocardia.

Contraindications to use of Sydnopharmum

• hypersensitivity to the making drug components;
• arterial hypotension (if systolic arterial pressure is lower than 100 mm Hg);
• collapse, cardiogenic shock, acute myocardial infarction (with arterial hypotension);
• age up to 18 years;
• pregnancy and period of feeding by a breast.

With care Sydnopharmum needs to be used at patients with the hemorrhagic stroke in the anamnesis raised by the intracranial pressure, tendency to arterial hypotension, glaucoma (especially closed-angle).

Route of administration and doses

According to the instruction Sydnopharmum should be accepted inside, swallowing entirely, washing down with enough water, irrespective of meal.

Usually there begin with small doses 1 – 2 mg two times a day. In case of need frequency rate of appointment can be increased to 3 times a day. The maximum dose of Sydnopharmum makes 6 mg a day.

Duration of treatment and dosage of drug are selected the attending physician individually. According to reviews Sydnopharmum is well transferred by patients and effectively prevents development of attacks of stenocardia.

Side effect of Sydnopharmum

According to responses Sydnopharmum seldom causes side reactions. The following most often occurs among them: a headache (which disappears at further administration of drug), dizziness, lowering of arterial pressure, erubescence of the person, nausea, a loss of appetite. At patients with initially low arterial pressure development of a collapse is possible. Seldom at reception of Sydnopharmum, according to reviews, there are allergic reactions (skin rash, a small tortoiseshell, a bronchospasm, an acute anaphylaxis), delay of speed of motor and mental reactions (usually in an initiation of treatment), diarrhea.

Overdose

Symptoms of overdose of Sydnopharmum are: severe headaches, tachycardia, the expressed lowering of arterial pressure. Therapy – symptomatic. There is no specific antidote.

Interaction of Sydnopharmum with other medicines

At a concomitant use with other hypotensive and vasodilating drugs, and also ethanol expressiveness of anti-hypertensive effect increases.

Use of Sydnopharmum along with drugs of acetylsalicylic acid increases antiagregantny activity.

Special instructions

According to the instruction Sydnopharmum cannot be used for stopping of attacks of stenocardia.

The first dose of drug is appointed with care and under control of arterial pressure because of a possibility of emergence of headaches and excessive decrease in the ABP.

Dose adjustment of Sydnopharmum is necessary for patients of advanced and senile age, and also patients with the broken function of livers/kidneys.

As drug can change the speed of motor and psychological reactions, during treatment (especially at its beginning) it is necessary to refuse driving and work with moving mechanisms.

Sydnopharmum analogs

Analogs of Sydnopharmum are: dilasidy, корвамин, Corvotonum, Molsidominum. Before replacement of Sydnopharmum with an analog it is necessary to consult with the doctor.