Solpadein

Solpadein – the combined analgetic antipyretic.

Solpadein's list and form of release

Solpadein release in the form of tablets of two types:

• kapsulovidny tablets of the extended form of white color, with red marking of "Solpadeine" on one party;
• soluble tablets of white color with risky on the one hand.

Solpadein's list:

• active components (both forms): caffeine of 30 mg, paracetamol of 500 mg, Codeini phosphas гемигидрат 8 mg;

• auxiliary components (tablets kapsulovidny): corn starch, soluble starch, stearic acid, ethanol of 95%, microcrystallic cellulose, the purified talc, magnesium stearate, potassium sorbate, povidone, demineralized water, crimson (Е 122), a gidroksipropilmetiltsellyuloza;
• auxiliary components (soluble tablets): sorbitol, sodium lauryl sulfate, anhydrous sodium carbonate, диметикон, поливидон, sodium bicarbonate, sodium saccharin, anhydrous citric acid.

Solpadein in the form of kapsulovidny tablets produce 5, 6, 8 and 12 pieces in blisters. In the form of soluble tablets Solpadein produce 2 pieces in strips.

Solpadein's analogs are the following medicines: An aurora of jotas hoarsed, AntiGrippin, Apap night, Askopar, Bolaren, Vokasept, Gripgo, Gripmaks, Gripotsitron, Gripustop, Dolar, Kold-iks, Coldrex, Kombigripp, Kofan, Lemsip max., Maksikold, Neogrip, Nolgrip, Paravit, Radikold, Rinza, Rinostop, Spazgo, Stopgripan, Taylolfen of jotas, Tilofen, Trimol, Pharmatsitron, Ferveks, Flyukoldeks, Tsiklopar, Citramonum, Efferalgan.

Pharmacological action

Three active ingredients are Solpadein's part: paracetamol, caffeine and codeine. Paracetamol has analgeziruyushchy and febrifugal effect on an organism.

Caffeine has all-tonic effect. According to Solpadein reduces drowsiness, removes feeling of fatigue, increases physical and intellectual effeciency, at arterial hypotension raises the ABP, increases ChSS.

The codeine which is Solpadein's part has analgeziruyushchy effect on an organism and improves portability of pain.

Indications to Solpadein's use

According to the instruction Solpadein is shown to children 12 years and the adult are more senior at a pain syndrome:

• dentagra;
• pain at radiculitis and stretchings;
• headache;
• migraine;
• painful periods;
• neuralgia;
• pharyngalgia;
• joint pain and muscles;
• pains at sinusitis.

Besides, Solpadein according to the instruction apply to decrease in body temperature at children 12 years both adult are more senior at infectious and inflammatory and catarrhal diseases.

Contraindications to Solpadein's use

In the instruction to Solpadein the following contraindications are specified:

• glaucoma;
• blood diseases (anemia, thrombocytopenia);
• arterial hypertension;
• genetic deficit glyukozo-6-fosfatdegidrogenazy;
• the expressed renal failures and a liver;
• lactation;
• respiratory insufficiency, the increased intracranial pressure, states after a craniocereberal injury;
• pregnancy;
• children's age up to 12 years;
• hypersensitivity to one or several components of drug.

According to Solpadein it is not necessary to accept together with other paratsetamolsoderzhashchy medicines.

It is necessary to appoint with care Solpadein according to the instruction at:

• to bronchial asthma;
• Gilbert's syndrome (constitutional hyperbilirubinemia);
• advanced age;
• inborn hyperbilirubinemia (syndromes of the Rotor and Cudgel Johnson).

Route of administration of Solpadein and mode of dosing

According to the instruction Solpadein is intended for intake, after food. Soluble tablets before reception dissolve in half of glass of water.

To children 16 years are more senior and the adult, as a rule, appoint on 1-2 таб. from three to four times a day. The interval between administrations of drug or Solpadein's analogs should not be less than four hours. The maximum one-time dosage – 2 таб., daily – no more than 8 таб.

To children aged from 12 up to 16 years appoint Solpadein according to the instruction in a dosage 1 таб. from three to four times a day. The maximum one-time dosage – 1 таб., daily – no more than 4 таб.

It is longer not necessary to accept drug or Solpadein's analogs three days as an antipyretic, and longer than five days as anesthetic.

Solpadein's use during pregnancy and breastfeeding

Drug and Solpadein's analogs are contraindicated during pregnancy. During breastfeeding it is not necessary to apply Solpadein: according to its operating components are allocated with breast milk.

Side effects

According to responses Solpadein is well had by patients. Emergence of the following side effects from various systems of life activity of an organism is possible:

• dizziness, drowsiness, sleep disorder;
• urticaria, skin rash, itch, Quincke's edema;
• lock, pain in epigastriums, nausea;
• methemoglobinemia, thrombocytopenia, anemia;
• cardiopalmus.

According to Solpadein at prolonged use in high dosages can cause a renal failure and a liver.

Overdose

The overdose by Solpadein according to reviews causes the following symptoms:

• stomach aches;
• nausea;
• perspiration;
• tachycardia;
• pallor of integuments;
• ring in ears;
• spasms;
• collapse;
• the confused consciousness;
• bronchospasm;
• drowsiness;
• the complicated breath.

In case of overdose drug or Solpadein's analog need to be made a gastric lavage, to accept absorbent carbon and to carry out a symptomatic treatment.

Medicinal interaction

At prolonged use of drug or Solpadein's analog the effect of indirect anticoagulants amplifies that increases probability of development of bleedings.

Combined use of Solpadein with:

• inductors of a microsomal oxidation of a liver increases products of hydroxylated active metabolites that can lead to development of heavy intoxication;
• inhibitors of a microsomal oxidation reduces risk of a hepatotoxic action of paracetamol;
• uricosuric drugs reduces action of the last.

The codeine which is Solpadein's part strengthens effect of sedatives, analgetics and somnolent drugs.

The caffeine which is Solpadein's part accelerates ergotamine absorption.

Storage conditions

Drug is stored in the dry cool place. Soluble tablets store not longer than 4 years, kapsulovidny – not longer than 5 years.