Spazmalgon

Spazmalgon is the drug representing a combination of non-steroidal anti-inflammatory drug, a spasmolysant and M-holinoblokatora. On the action mechanism drug Spazmalgon is carried to group of analgetics with the expressed spasmolytic action.

The mechanism of action is based on pharmacological effects of the substances which are Spazmalgon's part.

Composition of drug

The following active ingredients are Spazmalgon's part:

• metamizole sodium – the substance relating to group of the non-steroidal anti-inflammatory drugs derivative of pyrazyl ketone. This medicinal substance has strong analgetic (anesthetic) effect, and also renders antiinflammatory and antipyretic (febrifugal) action. The mechanism of effect of this drug consists in inhibition of a cyclooxygenase way of transformation of arachidonic acid therefore production of pro-inflammatory prostaglandins, thromboxane and prostacyclins decreases. Metamizole sodium equally inhibits both isoforms of cyclooxygenase – TsOG-1, TsOG-2. Thus, the analgetic effect of the metamizole sodium which is Spazmalgon's part is based on oppression of influence of mediators of an inflammation on the terminations of pain receptors;
• pitofenona a hydrochloride – substance from group of derivatives of piperidine, a myotropic spasmolysant. Possesses papaverinopodobny action, effectively reduces a tone of smooth muscles. Existence of this component as a part of Spazmalgon promotes elimination of the pain caused by a spasm of unstriated muscles of internals;

• fenpiveriniya bromide – medicinal substance from the M-holinoblokatorov group. Causes decrease in a spasm of the unstriated muscles located in internals, reduces motility of digestive tract, and also biliary and urinary tract.

The components which are Spazmalgon's part quickly enough are soaked up in a GIT, their maximum concentration in plasma is observed in an hour after Spazmalgon's use. Bioavailability reaches about 85%.

Indications to use

Thanks to the unique list of Spazmalgon of the indication to its appointment are quite extensive.

The tableted Spazmalgon apply at a symptomatic treatment of the weak or moderately expressed pain syndrome, in particular at the following diseases:

• pathology of an urinary system with a pain syndrome and disturbance of process of an urination, including inflammatory diseases and an urolithiasis;
• Spazmalgon apply at intestinal and gastric gripes, and also other pathology of a GIT which is followed by a spasm of smooth muscle cells;
• cholelithiasis;
• ZhVP dyskinesia.

At the pain syndrome accompanying a dysmenorrhea and also at pathology of a musculoskeletal system use of the tableted Spazmalgon is possible.

Indications to Spazmalgon's use in an injection form – stopping of a pain syndrome of high intensity at renal colic and other pathology of MVS, a postcholecystectomy syndrome, hepatic colic and other diseases of an abdominal cavity and small pelvis.

Spazmalgon routes of administration

According to the instruction, Spazmalgon in the form of tablets apply orally, without crushing at the same time a tablet, plentifully washing down with water. According to indications Spazmalgon it is possible to accept in a half dose, for this purpose it is necessary to pull down a tablet on the line.

Duration of treatment and Spazmalgon's dosage depend on specific nosological unit and are defined only by the doctor.

Spazmalgon's dosage for adults and teenagers of 15 years usually makes 1-2 pill which is taken 2-3 times a day.

Dosage for children of 13-15 years – 1 tablet with the same frequency rate of reception (it is no more than three tablets in days).

Dosage for children of 9-13 years – a half of a tablet at most three times a day.

According to the instruction, Spazmalgon do not recommend to use longer, than three days.

According to indications Spazmalgon can be appointed the doctor in other dosage.

Drug Spazmalgon according to the instruction in an injection form can be used only for intramuscular use. The dosage and frequency rate of use of Spazmalgon in injections are defined by the attending physician.

Contraindications to use

According to the instruction, Spazmalgon it is impossible to apply at:

• hypersensitivity to the substances which are Spazmalgon's part;
• allergies to other drugs from the NPVS group;
• estimated surgical pathology;
• heavy renal or hepatic pathology;
• to closed-angle glaucoma;
• tachyarrhythmias;
• impassability of a GIT;

• kollaptoidny states.

Side effects

Spazmalgon and analogs of drug are capable to cause a number of side effects: nausea, vomiting, an indisposition, dryness in a mouth, an exacerbation of gastritis and a round ulcer, increase in arterial pressure, acceleration ChSS, an agranulocytosis, a leukopenia, anemia, a headache, an acrimony, the complicated urination, allergic reactions (an itch, urticaria, a scalded skin syndrome, a toxic epidermal necrolysis).

If at Spazmalgon's use or analogs there were above described effects, surely address to medical institution.

Spazmalgon's use at pregnancy

The reliable data speaking about safety of use of Spazmalgon at pregnancy no.

Spazmalgon's analogs

On sale well huge number of analogs of Spazmalgon: Baralgetas, Baralginus, Took, Bralangin, Maksigan, Realgin, Renalgan, Reonalgon, Spazgan, Spazmadol, Spazmil, Spazmogard, Plenalgin and other drugs.

Spazmalgon and analogs of drug it is necessary to accept only on doctor's orders. Surely in detail study the instruction to Spazmalgon before its use.