Телфаст

Телфаст – means for treatment of allergic diseases.

Pharmacological action

Телфаст became the first antihistamine of the third generation and it is deprived of many side effects of the previous two generations. The main component of drug – фексофенадин which is an active metabolite of a terfenadin thanks to этомуон has twice big affinity to histamine H1 receptors. Телфаст vysokoizbiratelno contacts H1 receptors and, blocking them, it does not allow to be shown to biological effects of a histamine in the form of symptoms of allergic diseases (allergic dermatitis, cold, sneezing, dacryagogue, a skin itch, etc.). Drug is capable to stabilize somewhat membranes of mast cells, preventing and reducing release from them biologically active agents, first of all a histamine.

Unlike the analogs Telfast does not get through a blood-brain barrier into a brain therefore has no sedative properties. It does not influence the speed of mental reactions and ability to concentrate attention, for example, at management of transport or during study. Телфаст on the instruktsiyena causes accustomings even at long use.

The research of effect of drug was conducted as invitro, and in clinical conditions, and everywhere he confirmed the high performance. It was proved what in comparison with the analogs of Telfast does not influence other receptors, including kinds of histamine N1-and H2 receptors. It has no anticholinergic and anti-adrenergic activity therefore side effects from stimulation of other types of receptors are absent.

Телфаст does not change slow potassium currents therefore does not influence a heart electrophysiology in any way – QT interval on the electrocardiogram does not change during administration of drug. Lack of cardiotoxicity does it by an alternative to a terfenadin.

Drug is quickly soaked up, its medical effect appears in 1 hour after intake, reaching the maximum force in 6 hours. The general duration of action of Telfast according to the instruction makes slightly more than 24 hours, thanks to it it can be accepted once a day. Force of action has it linear dependence on the accepted dose. Medicine is practically not exposed to metabolism in an organism and is removed in an invariable view with a stake (80%) and urine (10%).

Release form

Drug is produced in tablets on 30 mg (a children's form), by 120 mg and 180 mg.

Indications to Telfast's use

Телфаст according to the instruction it is recommended for treatment of such allergic diseases as seasonal allergic rhinitis and hay fever, a chronic idiopathic and allergic small tortoiseshell, Quincke's diseases (Quincke's edemas).

Contraindications

It is impossible to accept drug at its individual intolerance, during pregnancy and feeding by a breast. Reviews of Telfasta at children up to 6 years are absent therefore administration of drug for them is not recommended. With caution it is necessary to take it at pathology of a liver and kidneys.

Application instruction of Telfast

Drug is accepted inside once a day, washing down with enough water. Though food also does not influence receipt of medicine in blood, it is desirable to accept it to food. The concomitant use with antacids slows down Telfast's absorption therefore between them there has to be an interval not less than 2 hours. Researches showed that elderly patients do not need recalculation of a dose towards its reduction or lengthening of an interval between receptions.

For treatment of seasonal allergic rhinitis, since 12-year age, recommend to accept 120 mg of drug once a day, in case of a chronic idiopathic small tortoiseshell and Quincke's diseases of 180 mg once a day. To children from 6 to 12 years Telfast appoint 30 mg once a day. Duration of a course is individual, is defined by the attending physician. Long reception of Telfast up to 4 – 6 weeks is possible.

Side effect of Telfast

According to Telfast it is well transferred by patients, occasionally there are headaches, dizziness, nausea. Extremely seldom register cases of an asthma, a dermahemia and anaphylactic reactions.