Termikon

Termikon – the synthetic antifungal means applied to treatment of dermatomycoses and onychomycoses.

Pharmacological action

Active component of Termikon has the expressed antifungal effect. Drug according to the instruction shows activity concerning such dermatophytes as:

• Trichophyton, including types of rubrum, mentagrophytes, violaceum, tonsurans, verrucosum;
• Epidermophyton floccosum;
• Microsporum canis.

In low concentration Termikon is capable to have fungicidal effect on:

• Dermatophytes;
• Some dimorphous mushrooms;
• Mold mushrooms (including Cladosporium, Aspergillus and Scopulariopsis brevicaulis).

Besides, Termikon according to the instruction has fungistatic or fungicidal effect on barmy mushrooms of the sort Candida and their mitselialny forms.

Termikon, affecting cellular membranes of a mushroom, breaks an early stage of biosynthesis and leads of mushroom cells to death.

Termikon's use inside is not effective in cases multi-colored depriving which causes Pityrosporum orbiculare (Malassezia furfur).

Release form

Termikon release in the form of tablets, white with a yellowish shade, which part 250 mg of a terbinafin are. On 7 pieces in strip packagings.

Also Termikon produce in the form of 1% of cream (10 g or 15 g) and spray (on 15 g or 30 g) for external use.

Termikon's analogs

The following medicines belong to the main analogs of Termikon on active ingredient: Atifin, Bramizil, Terbizil, Terbinafin Sandoz, Terbifin, Tebikur, Qidokan, Ekziter, Fungoterbin, Lamizil, Binafin.

Also Termikon's analog on a way of action is the drug Griseofulvin in several dosage forms.

Indications to Termikon's use

According to the instruction Termikon appoint at:

• Heavy widespread dermatomycoses of smooth skin of extremities and trunks which usually demand system treatment;
• Mycoses of a pilar part of the head (at such diseases as a trichophytosis, a microsporia);
• Candidiases of mucous membranes and skin;
• Onychomycoses;
• Mycoses of skin and nails which are caused by the Trichophyton group, and also Epidermophyton floccosum and the Microsporum group (gypseum and canis).

Contraindications

Contraindications to Termikon's use are the following cases:

• Lactation period;
• Pregnancy (owing to lack of the necessary data confirming efficiency and safety of use of le
• Age up to three years (or the mass of the child is less than 20 kg);
• Hypersensitivity to Termikon's components.

Also there is a number of states at which Termikon according to the instruction it is necessary to accept with extra care. Treat them:

• Alcoholism;
• Both renal, and liver failure;
• Existence of tumors;
• Oppression of a marrowy hemopoiesis;
• Occlusal diseases of vessels of extremities;
• Various diseases connected with a metabolism.

At psoriasis Termikon it is also necessary to take with caution not to provoke his aggravation.

At the carried-out therapy it is necessary to consider that at irregular reception of Termikon or if treatment is complete before full treatment, the risk of development of a recurrence increases.

Termikon route of administration

Duration of treatment by Termikon, and also the mode of dosing is appointed individually and is defined by existence of associated diseases.

Termikon according to the instruction appoint on one tablet once a day, it is desirable – after meal.

Usually average duration of therapy makes at:

• Trunk dermatomycosis – one month;
• Onychomycosis – 6-12 weeks;
• Candidiasis of shins, and also skin and mucous membranes – from two weeks to one month;
• Mycosis of a pilar part of the head – more than a month;
• Dermatomycosis of feet – 2-6 weeks.

At renal failures Termikon's dose is reduced, as a rule, twice.

Cream and spray Termikon apply on the cleared and dried skin up to two times a day. In cases of emergence of an intertrigo of a site of application of ointment (especially for the night) it is necessary to cover with a gauze.

According to the instruction treat the main symptoms of overdose by Termikon:

• Nausea or vomiting;
• Dizziness;
• Pains in the lower part of a stomach, and in certain cases – in epigastric area.

Medicinal interaction of Termikon

Combined use of Termikon with a number of medicines is not recommended (in order to avoid metabolism delay), namely:

• With beta1-adrenoblockers, such, as метопролол or propranolol;
• With tricyclic antidepressants and the selection blockers of the return serotonin reuptake, such, as флувоксамин or desipramine;
• With MAO inhibitors of V type;
• With antiarrhytmic means, such, as флекаинид or пропафенон;
• With antipsychotic to drugs, such as haloperidol or Chlorpromazinum.

Can lead a concomitant use of Termikon and oral contraceptives to disturbance of a menstrual cycle.

The risk of development of a hepatotoxic increases at simultaneous use of Termikon with ethanol or other gepatotoksichny drugs.

Side effects of Termikon

From digestion at Termikon's reception according to reviews treat the most frequent frustration:

• Dyspepsia;
• Abdominal pain, sometimes – feeling of excessive overflow of a stomach;
• Disturbances of work of flavoring receptors (in certain cases there is a full loss of flavoring feelings which is, as a rule, recovered in two-three weeks after the end of treatment);
• Nausea;
• Loss of appetite;
• Diarrhea.

Extremely seldom Termikon according to reviews causes development of gepatobiliarny disturbances (differently – cholestatic jaundice).

The most probable allergic reactions arising at Termikon's reception are urticaria and skin rash. In extremely exceptional cases medicine leads to development:

• Toxic epidermal necrolysis (differently – a Lyell's disease);
• Malignant exudative erythema (differently – Stephens-Johnson's syndrome);
• Anaphylactoid reactions.

At development of allergic reactions during therapy Termikon, as a rule, cancel.

At Termikon's use according to reviews treat other disturbances of important systems of an organism:

• Mialgiya and arthralgia (musculoskeletal system);
• Thrombocytopenia, agranulocytosis and neutropenia (system of a hemopoiesis).

Storage conditions

Termikon treats a number of the antifungal drugs which are released from drugstores on medical appointment. A period of storage – no more than 36 months (at a temperature up to 25 °C).