Tutabin
Application instruction:
Tutabin is the medicine possessing antineoplastic action and used for treatment of some oncological diseases. Its main active ingredient is Kapetsitabin.
Pharmacological action of Tutabin
Tutabin possesses the selection cytotoxic action. Getting to tumor cells, he under the influence of a tumoral angiogenic factor (timidifosforilaza) turns in 5-ftoruratsit. Activity in fabrics of malignant tumors of thymidinephosphorylase is several times higher, than in cells of healthy fabric or blood. Therefore also concentration of a 5-ftoruratsil in them is 4 times higher. As a result of further metabolism of a 5-ftoruratsil a 5-ftorurdina the triphosphate and 5-fluorine-2-dezoksiuridina monophosphate possessing powerful cytotoxic action are formed.
Indications to Tutabin's use
According to the instruction, Tutabin apply to cancer therapy of a mammary gland including with the remote metastasises. This medicine can be used at the patients having contraindications to performing therapy by anthracyclines. According to reviews, Tutabin in some cases is effective for treatment of malignant new growths resistant (steady) against drugs of anthracycline group and Paklitakselu.
Application instruction
The mode of reception and dosing of tablets Tutabin is established by the doctor individually taking into account a type of a tumor, the scheme of antineoplastic therapy, a stage of a disease, a condition of the hemopoietic system.
At the standard scheme of a tablet of Tutabin are appointed from calculation 2,5g active ingredient to each square meter of the area of a body of the patient. The daily dose is divided into two receptions and accepted in half an hour after food. Therapy course duration – 14 days, after a week break it can be continued.
Tutabin's dosage can be lowered at its bad portability.
Contraindications
According to the instruction, Tutabin is contraindicated in the following cases:
- High individual sensitivity to medicine components;
- Heavy liver failure;
- Deficit of a dihydropyrimidindehydrogenase;
- Pregnancy and period of a lactation;
- The age of the patient is younger than 18 years.
Tutabin it is impossible to appoint tablets along with Sorivudin or Brivudin, and also with their structural analogs.
According to reviews, Tutabin it is necessary to use with huge care in treatment of the patients having a renal failure, coronary heart disease, receiving anticoagulants of a coumarinic row. At purpose of tablets of Tutabin elderly people should control regularly a condition of the hemopoietic and coagulant systems, and also once a month to carry out an ECG since drug possesses cardiotoxic action.
Side effects of Tutabin
In the instruction to Tutabin it is noted that use of this medicine can lead to development of side effects from various systems of bodies:
- From digestive tract: stomatitis, pains in epigastriums, disturbances of flavoring feelings, a hyperbilirubinemia, oral cavity candidiasis, a loss of appetite, a meteorism, dryness in a mouth, a lock or a diarrhea, nausea, vomiting;
- From a nervous system: adynamy, sleep disorders, dizzinesses, paresthesias, headache, weakness, increased fatigue;
- From integuments: cracks and/or hyperpegmentation of skin, focal peeling, itch, alopention, dermatitis, palmar and bottom syndrome.
Tutabin's reception, according to reviews, can lead to fervescence, the strengthened slezootdeleniye, hypostases of the lower extremities, anemia, extremity and waist pains.
Storage conditions and issues from drugstores
Tablets Tutabin are released from a drugstore only according to the recipe of the doctor. They should be stored at the room temperature in the dry and protected from light place unavailable to children and domestic animals.
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