Vinpotropil

Vinpotropil – the nootropic medicine improving cerebral circulation.

Form of release and structure

• Tablets, film coated: oval, light brown color with a grayish shade, with risky, on cross section – almost white color (on 10 pieces in blister strip packagings, in a cardboard pack of 3 or 6 packagings);
• Capsules: the size No. 0, yellow color with a lid of red color; contents – powder of white color, are possible existence of separate lumps and crystals (on 10 pieces in blister strip packagings, in a cardboard pack of 2, 3, 5 or 10 packagings; on 15 pieces in blister strip packagings, in a cardboard pack of 2, 4 or 6 packagings; on 15 or 50 pieces in polyethylene bottles, in a cardboard pack 1 bottle);
• Concentrate for preparation of solution for infusions: transparent, colourless or slightly painted (on 5 ml in dark glass ampoules: 5 ampoules in a cardboard pack; 5 ampoules in a blister strip packaging, in a cardboard pack 2 packagings; 10 ampoules in a blister strip packaging, in a cardboard pack 1 or 2 packagings).

Active ingredients in 1 tablet:

• Vinpocetine – 10 mg;
• Piracetam – 800 mg.

Active ingredients in 1 capsule:

• Vinpocetine – 5 mg;
• Piracetam – 400 mg.

Active ingredients in 1 ml of a concentrate:

• Vinpocetine – 1 mg;
• Piracetam – 80 mg.

Excipients of tablets: croscarmellose sodium, hydrophosphate calcium dihydrate, povidone, magnesium stearate, cellulose microcrystallic, talc.

Structure of a cover of tablets: опадрай the II brown (lactoses monohydrate, macrogoal, gipromelloza, titanium dioxide, dyes ferrous oxide red and ferrous oxide black).

Excipients of capsules: calcium stearate and lactose.

Concentrate excipients: sodium disulphite (sodium metabisulphite), succinic acid, ascorbic acid, water for injections.

Indications to use

For all dosage forms:

• Parkinsonism of vascular genesis;
• Insufficiency of cerebral circulation (the recovery period after a hemorrhagic and ischemic stroke);
• Psychoorganic syndrome with dominance of signs of an adynamia and adynamy;
• Intoxications.

In addition for tablets:

• Symptomatic treatment вертиго;
• Chronic insufficiency of cerebral circulation of posttraumatic and hypertensive genesis;
• Prevention of kinetoz and migraine.

In addition for capsules and a concentrate for preparation of infusions:

• Labyrinthopathies;
• Asthenic syndrome;
• Brain injuries and other diseases of the central nervous system which are followed by decrease intellectual мнестических functions;
• Menyer's syndrome;
• Encephalopathies of various genesis, including at alcoholism.

Besides, Vinpotropil in capsules appoint for prevention of kinetoz and migraine.

Contraindications

Absolute:

• Acute stage of a hemorrhagic stroke;
• Coronary heart disease (heavy current);
• The expressed disturbances of a heart rhythm;
• Deficit of lactase, glyukozo-galaktozny malabsorption, lactose intolerance (for tablets);
• Renal/liver failure;
• Age up to 18 years;
• Pregnancy;
• Lactation;
• Hypersensitivity to drug.

Relative (in connection with risk of development of complications it is necessary to observe extra care):

• Heavy bleeding;
• Disturbance of a hemostasis;
• Viral hepatitis;
• Epilepsy;
• Alcoholic damage of a liver;
• High-quality hyperbilirubinemias (including Gilbert's syndrome);
• Alcoholism;
• Advanced age;
• Deficit glyukozo-6-fosfatdegidrogenazy (for tablets and capsules).

Route of administration and dosage

Tablets, film coated

In the form of tablets Vinpotropil accept inside, washing down with enough water, regardless of meal, 1 piece 2-3 times a day (the last reception has to be approximately in 4 hours prior to a dream). Depending on a clinical picture treatment can last from 2 weeks to 6 months that is defined strictly by the doctor. Before drug withdrawal the dose is recommended to be reduced gradually.

Capsules

In the form of capsules Vinpotropil accept inside 1-2 pieces 2-3 times a day (the last reception has to be approximately in 4 hours prior to a dream). During a maintenance therapy of the capsule appoint 1 piece 3 times a day. Depending on a clinical picture treatment can last from 2 weeks to 6 months. Before drug withdrawal the dose is recommended to be reduced gradually.

Concentrate for preparation of solution for infusions

The concentrate Vinpotropil is entered intravenously kapelno with a speed up to 80 thaws a minute of 1 times a day. The single dose makes 2-3 ampoules which are previously diluted with 500 ml of 0,9% of solution of sodium of chloride or other solution containing a dextrose. Duration of therapy makes 10-14 days. If necessary the course is repeated in 6-8 weeks.

After improvement of a condition of the patient transfer to a peroral form of drug.

Side effects

• Cardiovascular system: change of the electrocardiogram (lengthening of an interval of QT, ST segment depression), lability of arterial pressure, premature ventricular contraction, feeling of inflows, tachycardia, deterioration in a course of stenocardia;
• Central nervous system: dizziness, irritability, a headache, decline in the ability to concentration of attention, a sleep disorder, disbalance, motive disinhibition, uneasiness, an ataxy, a hyperphrenia, a tremor, spasms, extrapyramidal frustration (including a hyperkinesia), a depression;
• Alimentary system: dryness in a mouth, diarrhea, heartburn, nausea, a gastralgia, vomiting;
• Integuments: dermatitis, urticaria, reddening, itch;
• Sense bodys: вертиго;
• Others: increase in body weight, the general weakness, an adynamy, the increased sweating, increase in sexual activity, allergic reactions.

Besides, at use of a concentrate for preparation of solution for infusions local reactions are possible: pain in an injection site and thrombophlebitis.

Special instructions

Patients for whom the prolonged QT interval is diagnosed during treatment should control the electrocardiogram periodically.

Piracetam – one of active ingredients of Vinpotropil – exerts impact on aggregation of thrombocytes in this connection patients are recommended to be careful at purpose of drug with disturbance of a hemostasis, with symptoms of heavy bleeding, and also during extensive surgeries.

Patients with a lactose intolerance should consider that 1 capsule contains about 225 mg of lactose.

During treatment it is necessary to be careful at control of vehicles and performance of potentially dangerous types of activity.

Medicinal interaction

• Heparin: the risk of a hemorrhagic complication increases;
• Psychostimulants, antipsychotic means, hormones of a thyroid gland: their effects amplify;
• Indirect anticoagulants, including аценокумарол: their action amplifies, more expressed decrease in aggregation of thrombocytes, content of fibrinogen, Villebrand's factor, viscosity of blood and plasma is noted;
• Methyldopum: its hypotensive action amplifies (it is necessary to control arterial pressure);
• Anticonvulsant drugs: their action is weakened, the convulsive threshold decreases.

The data confirming a possibility of interaction of Vinpotropil with drugs of the central and antiarrhythmic action are absent, nevertheless, at purpose of a similar combination it is necessary to be careful.

The concentrate for preparation of solution for infusions is compatible from 5, 10 and 20% solutions of a dextrose, 5, 10 and 20% fructose solutions, Ringer's solution, 0,9% solution of sodium of chloride, 6 and 10% hydroxyethylstarch, 20% Mannitolum solution.

Terms and storage conditions

To store at a temperature up to 25 ºС in the dry dark place unavailable to children.

Period of validity:

• Tablets, capsules – 2 years;
• Concentrate for preparation of solution for infusions – 3 years.