Alfuzozin – the selection blocker of alfa1-adrenoceptors (is preferential in a zone of an urethra, predyostatelny gland and a triangle uric пузыря) reducing pressure in an urethra, reducing resistance to urine current, facilitating an urination and eliminating a dysuria.
Active agent – an alfuzozina a hydrochloride:
Auxiliary components of tablets of the prolonged action: коллидон SR (polyvinyl acetate, povidone, sodium lauryl sulfate, silicon dioxide), magnesium stearate, lactoses monohydrate, silicon dioxide colloid.
Additional substances of tablets with controlled release: magnesium stearate for pharmaceutical industry, povidone sredneyomolekulyarny (polyvinylpirrolidone middlemolecular), a hypro rod (hydroxypropyl cellulose), calcium of a gidroyofosfat a dihydrate (calcium phosphate disubstituted 2-water), cellulose microcrystallic, titanium dioxide, a gipromelloz (gidroksipropilmetiltsellyuloz), talc, the castor oil hydrogenated dye ferrous oxide yellow.
Alfuzozin – drug for treatment of the functional disturbances of an urination caused by a benign hyperplasia of a prostate.
Alfuzozin is not applied to treatment of women.
Alfuzozin it is necessary to accept inside, swallowing of tablets entirely and washing down with enough water.
The recommended daily dose makes 10 mg – on 1 tablet of 10 mg of 1 times a day or on 1 tablet of 5 mg 2 times a day, in the morning and in the evening, at the same time it is necessary to begin treatment with evening reception.
To elderly people and patients who receive the accompanying hypotensive therapy appoint 5 mg of 1 times a day (in the evening). If necessary increase in a dose up to 10 mg is possible.
In certain cases, especially at the patients receiving hypotensive drugs within several hours after Alfuzozin's reception postural hypotension, with symptoms (sweating, fatigue and dizziness) and without them can develop. Such persons need to remain in a prone position before improvement of a state. These phenomena are more often than a vremenna, arise at the beginning of therapy and, as a rule, are not a reason for drug withdrawal.
At combined use of antihypertensives, especially blockers of calcium channels, it is necessary to adjust their doses since the lowering of arterial pressure is possible, up to development of a collapse.
Patients with coronary insufficiency have to accept Alfuzozin at the same time with specific treatment of coronary insufficiency. If stenocardia is returned or worsens, Alfuzozin it is necessary to cancel.
There are no data on a negative impact of drug on the speed of reactions and ability to concentration of attention. However in an initiation of treatment there can be an adynamy and dizziness therefore patients should be careful when driving and performing potentially dangerous types of works.
Alfuzozin it is impossible to apply along with other alfa1-adrenoblockers as there is strengthening of hypotensive effect owing to what the risk of development of heavy postural hypotension increases.
Drug strengthens effect of anti-hypertensive means, including blockers of slow calcium channels (the additive action is noted) and the general anesthetics (instability of arterial pressure is possible).
At simultaneous use of inhibitors of the CYP3A4 system (an itrakonazol, a ketokonazol, a ritonavir) concentration of an alfuzozin in blood increases.
To store at a temperature up to 25 ºС in the unavailable to children, protected from light and dry place.
Period of validity – 2 years.
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