Berlipril

Berlipril – the drug regulating the level of arterial pressure.

Form of release and structure

Berlipril is issued in tablets: round, slightly convex on both sides, with slanted edges, on one of the parties – risk (in blisters on 10 pieces, on 2, 3, 5 or 10 blisters in a pack cardboard).

Main active ingredient: enalapril a maleate, whose maintenance in:

• Berlipril of 5 - 5 mg (color of tablets white or almost white);
• Berlipril of 10 - 10 mg (color of tablets light brown, white impregnations are admissible);
• Berlipril of 20 - 20 mg (color of tablets light pink, impregnations of white and dark pink color are admissible).

As excipients are used: magnesium carbonate easy, magnesium stearate, lactoses monohydrate, sodium carboxymethylstarch, gelatin; Berlipril 10 and 20 include in addition ferrous oxide brown (E172).

Indications to use

• Chronic heart failure (combination therapy);
• Arterial hypertension (including renovascular);
• Asymptomatic dysfunction of a left ventricle as a result of the postponed myocardial infarction (combination therapy).

Contraindications

• The Quincke's disease developing owing to reception of APF (in the anamnesis);
• Porphyria;
• Pregnancy, and also breastfeeding period;
• Sensitivity to enalapril and other APF inhibitors;
• Children's and teenage age up to 18 years.

Berlipril apply with care in the presence of the following diseases / states:

• Primary hyper aldosteronism;
• Bilateral stenosis of renal arteries;
• Stenosis of an artery of the only kidney;
• Aortal stenosis;
• State after transplantation of a kidney;
• Mitral stenosis at problems with a hemodynamics;
• Idiopathic hypertrophic subaortal stenosis;
• Diseases of connecting fabric;
• Coronary heart disease;
• Hyperpotassemia;
• Cerebrovascular diseases;
• Diabetes mellitus;
• Liver failure;
• Renal failure with a proteinuria more than 1 g a day.

Observation of the doctor is necessary at therapy by Berlipril along with saluretics and immunodepressants, and also if age of the patient more than 65 years.
Route of administration and dosage

Berlipril's reception 5, 10, 20 does not depend on meal time.

For monotherapy at treatment of arterial hypertension the initial dose of drug of 5 mg of 1 times a day is appointed. If the clinical effect is not observed, the dose is raised on 5 mg in 1-2 weeks.

After the first acceptance of drug the patient is under medical observation, pressure (two-three hours) is not stabilized yet.

In need of increase in a dose (on condition of good tolerance of Berlipril), it is raised to 40 mg a day (in 1-2 receptions). In 2-3 weeks of the patient transfer to the supporting Berlipril's dosage – 10-40 mg a day (in 1 or 2 receptions).

For use as a part of complex therapy the following dosing is recommended:

• Moderate hypertensia: 10 mg/days on average, the most admissible dose – 40 mg/days;
• Renovascular hypertensia: an initial dose of 2,5-5 mg/days, maximum – 20 mg/days;
• Chronic heart failure: an initial dose of 2,5 mg (is accepted once), then the dose is raised by each three-four days on 2,5-5 mg, observing for clinical reactions (depending on the size of arterial pressure define the most admissible dose, but no more than 40 mg a day in 1 or 2 receptions). If at the patient low systolic pressure is observed (to 110 mm of mercury.), that treatment is begun with 1,25 mg, definition of the necessary supporting dosage carry out to the next 2-4 weeks (on average from 5 to 20 mg a day to 1 or 2 receptions);
• The dysfunction of a left ventricle proceeding asymptomatically: in an initiation of treatment drug is appointed by 2 times a day on 2,5 mg. The further dosage is selected, considering portability of drug the patient, as much as possible to 20 mg in 2 receptions.

Berlipril to patients at advanced age appoint no more than 1,25 mg in an initial dose.

At administration of drug it is not necessary to exceed the doses appointed by the doctor. In case of overdose it is expressed the ABP decreases, and on this background the stroke, a myocardial infarction, a stupor, thromboembolisms, spasms are possible. For treatment it is necessary to record the patient in horizontal position, to wash out to it a stomach, then to appoint sorbents, infusional therapy, administration of angiotensin ІІ, a hemodialysis.

Side effects

Berlipril's use can cause side reactions from different systems of an organism:

• Cardiovascular system: hypotension, a collapse orthostatic, stenocardia, a heart attack, pains behind a breast, arrhythmia, heartbeat, a syncope;
• Central and peripheral nervous system: sleeplessness, alarm, a headache, weakness, dizziness, the confused consciousness, drowsiness, fatigue; seldom, at acceptance of high doses – a depression, paresthesia, nervousness;
• Sense bodys: vision disorder, hearing, vestibular disturbances, sonitus;
• Alimentary system: anorexia, vomiting, dryness in a mouth, diarrhea, nausea; seldom – pancreatitis, intestinal impassability, hepatitis, abdominal pains, jaundice, dysfunction of biliary tract, a liver;
• Respiratory system: pharyngitis, short wind, dry unproductive cough, bronchospasm, pneumonitis intersticial, rhinorrhea;
• Urinary system: proteinuria, disturbance of renal function.

Besides, Berlipril's use can lead to an alopecia, decrease in a libido, inflows, allergic reactions of different extent of manifestation.

Special instructions

In the course of treatment it is necessary to control AP (arterial pressure), levels of hemoglobin, potassium, urea, transaminases, creatinine.

Prior to the beginning of surgical intervention it is important to report about reception of this medicine to the surgeon or the anesthesiologist.

Driving of motor transport or control of difficult mechanisms during therapy is undesirable.

Analogs

Direct analogs (synonyms): Bagopril, Renipril, Renitek, Ednit, Enalapril, Enam, Enap, Enarenal, Enafarm, Envas.

Drugs of similar action: Akkupro, Amprilan, Blokordil, Vazolong, Hypernik, Diropress, Zoniksem, Irumed, Captopril, Kovereks, Lizakard, Lizonorm, Liten, Metiapril, Parnavel, Perinpress, Ramigamma, Sinopril, Tritatsa, Fozikard, Hartil, etc.

Terms and storage conditions

To store in the place unavailable to children. Temperature of storage is up to 25 °C.

Period of validity – 3 years.