Clozapine
Application instruction:
Clozapine – antipsychotic drug with sedative action.
Form of release and structure
Clozapine is produced in two dosage forms:
- Tablets on 25 or 100 mg;
- Solution for injections of 2,5% (on 2 ml in ampoules).
Indications to use
- Psychomotor excitement at schizophrenia;
- Hallucinatory-dilision states, including nonsense and realities of vision gaining character;
- Maniacal syndrome, including inadequately increased mood, acceleration of rate of thinking, psychomotor excitement;
- Deterioration in mood;
- Other psychopathic diseases.
Contraindications
- Acute alcoholic and other intoksikatsionny psychoses;
- Diseases of cardiovascular system;
- Epilepsy;
- Glaucoma;
- Spasmophilia;
- Prostate adenoma;
- Intestines atony;
- First trimester of pregnancy;
- Hypersensitivity to drug components.
Route of administration and dosage
Clozapine in the form of tablets is accepted inside, regardless of meal.
Initial single dose – 50-100 mg, frequency rate of reception – 2-3 times a day. If necessary the daily dose is increased to 200-600 mg. As a maintenance therapy Clozapine is accepted on 25-200 mg in the evening.
The drug in the form of solution for injections is administered before going to bed intramusculary in a dose by 1-2 ml.
Side effects
During use of Clozapine the following side effects can develop: dryness in a mouth, confusion of consciousness, nonsense, drowsiness, muscular weakness, orthostatic hypotension, tachycardia, increase in body temperature, accommodation disturbance, kollaptoidny states.
In case of development of an agranulocytosis therapy needs to be interrupted immediately.
Special instructions
Before Clozapine use, and also in cases of development of uncharacteristic symptoms it is necessary to consult at the doctor.
During use of drug it is not necessary to manage motor transport.
Medicinal interaction
There are no data on interaction of Clozapine with other medicines.
Terms and storage conditions
To store in the place, dry, cool, unavailable to children.
Blood of the person "runs" on vessels under huge pressure and at disturbance of their integrity is capable to shoot of distance to 10 meters.
For the help to doctors in the choice of optimal solutions for treatment of various diseases the Cochrane scientific organization (Cochrane) will see off совм...
Section: Articles about health
White teeth and the Hollywood smile – a dream of many people. Long time was considered that the plaque on teeth and change of their color – destiny of those who incorrectly eat smokes and badly brushes teeth. But the paradox is available: at everything the variety of toothpastes existing today...
Section: Articles about health
We live during an advertizing era. Daily each person receives a solid portion of persuasive councils about what to eat to be healthy and successful. Products about which we will talk today are combined by the following circumstance: all of them are positioned as the most useful and the most suitable for inclusion in a morning meal. Unfortunately, it is not true: these 10 products do not suit for breakfasts at all....
Section: Articles about health
Kidneys perform the most important function of clarification of blood from those products of metabolic processes which cannot be used орг...
Section: Articles about health
The nature does not stand stagnation and monotony. It is known that tissues of a human body atrophy if do not receive necessary loadings. It fully belongs also to a cerebral cortex: when it is not given full-time job, it begins to function worse. In резуль...
Section: Articles about health
Striya (extension) are the defects of skin having an appearance of direct or wavy strips from 1 to 10 cm long and 1-5 mm wide. In most cases at women of a striya are located on a stomach, hips, a breast or buttocks. At athletes they can appear on shoulders and the internal surface of forearms. At initial stages of development of an extension have red or lilac color, but over time their coloring turns pale, and strips become whitish, getting a nacreous shade....
Section: Articles about health
"Epilepsy" doctors made the diagnosis in antique times. Displays of an illness and pattern of its development are very well studied. Odes...
Section: Articles about health
The state of health of the person depends on many factors. One of the most important is the constant, but not exhausting a physical activity. In the presence of various illnesses specialists often advise patients to do swimming which by right borrows ведущ...
Section: Articles about health
The person, as well as all other beings living on our planet feels weather changing. It is the normal meteosensitivity which is not causing to healthy people of special troubles. Meteodependence, on the contrary, is the morbid condition which is characterized by an exacerbation of chronic illnesses at change of air temperature, differences of atmospheric pressure, wind strengthening, magnetic storms and other "surprises" on which the nature is so generous. The people suffering from meteodependence have to з...
Section: Articles about health
All the known slogan "Protect Men!" arose not from scratch. In a sense, the nature created representatives of strong...
Section: Articles about health
High temperature - a frequent symptom of such widespread diseases as a SARS, quinsy, pneumonia, etc. To reduce heat, having facilitated a condition of the patient, doctors recommend to accept antipyretics, however their use is not always possible. Too h...
Section: Articles about health
All are familiar with cold, and practically everyone believes that he has sufficient knowledge and experience that correctly to treat it. In practice most of people makes mistakes in attempts to get rid of rhinitis, and divides numerous delusions it....
Section: Articles about health
Obesity is called by a disease of 21 centuries, for the last 100 years by the number of the people suffering from excess body weight, considerably increased...
Section: Articles about health
New year, wedding, birthday, office party – an occasion to drink at the Russian person will always be. How to reduce a negative impact of alcohol by an organism and to avoid a condition of strong intoxication? The most correct council – to refuse the use spirits напитк...
Section: Articles about health
For anybody not a secret that our country is one of the most "drinking" in the world. At clear understanding that the use of hard alcoholic drinks – occupation extremely harmful, most of Russians belong to alcoholism with unjustified loyalty. Apparently, existence of a set of myths in which tendency to excessive libations looks nearly positively is explained by it. It is worth getting acquainted with the most widespread of similar delusions and to be convinced in them not...
Section: Articles about health
Work of a brain is extremely complex and in many respects is not studied yet. It is confirmed also by the features of thought processes which are shown in...
Section: Articles about health
Nightmares belong to the most unpleasant frustration. Statistically, they happen at 4% of adults, and almost at 70% of children and teenagers. During a nightmare of people dreams himself in extremely difficult, life-threatening situation. It wakens suddenly, in...
Section: Articles about health
Smack in a mouth can arise in the natural way – as a result of lack of morning hygiene or reception of the corresponding food. However in certain cases its existence is a sign of certain pathologies, and allows to reveal an illness at an early stage. Depending on character of aftertaste – acid, salty, bitter, sweet – distinguish also diseases which accompany it....
Section: Articles about health
It seems, quite recently you brought the baby from maternity hospital, but time flew by, and here it is already going to join the first...
Section: Articles about health
Life of the modern woman is very difficult. Opportunities to realize itself are wide: it not only education and career, but also the most various hobbies from sport before needlework. It is not less important to build private life, paying an attention maximum to children, the husband, parents, e...
Section: Articles about health
For the time being the perspective of heart diseases seems to most of people remote and foggy. But sooner or later practically each adult faces extremely unpleasant feelings: sudden stethalgia. To be consoled at this time in a thought of what for a heart attack still early, will hardly turn out: if the person is impressionable, he, as a rule, has feeling of panic and fear of fast death. And meanwhile, it is very often possible to confuse pains with cardiac pains невралгическог...
Section: Articles about health
The number of long-livers is very small. One person from 5 thousand lives up to age of 90 years, and the centenary boundary steps only about...
Section: Articles about health
Sometimes it seems that modern society was divided into two camps: representatives of the first are sure that only the woman has to be responsible for contraception, representatives of the second, respectively, are sure that it is destiny of men. Meanwhile Dov has a question of contraception...
Section: Articles about health
Venereal diseases in medicine are called the infections which are transmitted preferential sexually, now they and are called - infections, sexually transmitted, or STD. Among them is also life-threatening. In spite of the fact that the majority of diseases such will respond to treatment, they are widespread everywhere, and there is no tendency to decrease in incidence. Besides, some of them promptly look younger: statistically, a third of young people at the age of 16-22 years of a str...
Section: Articles about health
Mushrooms - the surprising inhabitants of our planet having a set of wonderful qualities. Thanks to one of them, a mold mushroom of Penici...
Section: Articles about health
Helminthosis is one of the most widespread diseases. Statistically, any species of helminths infected every third inhabitant of the planet. Most of specialists even consider these data strongly underestimated: some uninvited "cohabitants" of N...
Section: Articles about health
Olive oil – the product capable to make a powerful contribution to health of the person if it includes it in the diet. The rich vitamin composition of oil does it by a product number one from many diseases including from deadly. Only two tablespoons of oil from olives in day prevent emergence of diseases of vessels and heart, cancer, problems with digestion, presenilation, a depression and many other illnesses which treatment would demand a lot of time and forces. Let's consider on...
Section: Articles about health