Дайвонекс

Дайвонекс – drug for treatment of psoriasis with anti-proliferative action.

Form of release and structure

Dosage forms:

• Solution for external use: transparent colourless liquid, slightly viscous structure (on 60 ml in polyethylene bottles, in a cardboard pack 1 bottle);
External
• use cream: homogeneous mass of white color (on 30 or 100 g in aluminum tubas, in a cardboard pack 1 tuba);
• Ointment for external use: from white with a yellow shade till white color, translucent (on 30 or 100 g in aluminum tubas, in a cardboard pack 1 tuba).

Content of active ingredient:

• 1 ml of solution – a kaltsipotriol monohydrate of 52,2 mkg that is equivalent to 50 mkg of a kaltsipotriol;
• 1 g of cream – a kaltsipotriol hydrate of 52,2 mkg that is equivalent to 50 mkg of a kaltsipotriol;
• 1 g of ointment – a kaltsipotriol monohydrate of 52,2 mkg that is equivalent to 50 mkg of a kaltsipotriol.

Auxiliary components:

• Solution: isopropanol, a hypro rod, left menthol, citrate sodium a dihydrate, propylene glycol, the water purified;
• Cream: cetostearyl alcohol (cetyl alcohol of 60%, stearyl alcohol of 40%), a macrogoal цетостеарат, chlorallylmethenamin chloride, dinatrium of an edetat a dihydrate, глицерол 85%, hydrophosphate sodium a dihydrate, paraffin white soft (contains about 10 ppm of alpha tocopherol), sodium hydroxide (to pH 7,5-9), liquid paraffin (contains about 10 ppm of alpha tocopherol), water;
• Ointment: macrogoal stearate, alpha tocopherol, propylene glycol, hydrophosphate sodium dihydrate, dinatrium of an edetat dihydrate, liquid paraffin, paraffin white soft, water.

Indications to use

Dayvoneks's use is shown for treatment of vulgar psoriasis.

Contraindications

• Period of pregnancy and breastfeeding;
• Hypersensitivity to drug components.

With care children are recommended to appoint solution.

Use of cream and ointment is contraindicated to patients with the diseases proceeding with calcium metabolism disturbance.

Age restrictions:

• Cream: up to 18 years;
• Ointment: up to 6 years.

With care use cream and ointment at an acute renal and liver failure, a hypercalcemia, a hypervitaminosis of vitamin D, a hypercalcuria, the instruction in the anamnesis of a nephrolithiasis and at treatment of patients 65 years are more senior.

Route of administration and dosage

Dayvoneks's drugs use outwardly, applying on skin of affected areas of a body 2 times a day, a course of treatment no more than 6-8 weeks. Usually after 1-2 weeks of use the clinical effect occurs.

The maximum daily dose of solution, cream or ointment should not exceed 15 g, week – 100 g.

If necessary frequency rate of putting cream or ointment can be reduced to 1 time a day.

Besides, it is shown, it is well transferred and simultaneous putting ointment in combination with cyclosporine and atsitretiny improves therapeutic effect. At a combination to glucocorticosteroids (GKS) use of drugs alternates, ointment is applied in the morning, GKS – in the evening.

The maximum week dose of ointment at treatment of children has age restrictions: from 6 to 12 years – 50 g, are more senior than 12 years – 75 g.

Side effects

Against the background of solution use in some cases perhaps passing irritation of skin, at exceeding of the mode of dosing – a hypercalcemia.

External use cream and ointment for external use

• Metabolism: very seldom – a hypercalcuria, a hypercalcemia;
• Immune system: very seldom – a small tortoiseshell, allergic reactions, a Quincke's disease;
• Dermatological reactions: often – burning sensation, an itch, irritation of skin, rash (erythematic, scaly, pustular, makulopapulezny, violent), dryness and a peeling of skin, an erythema; infrequently – an aggravation of symptoms of psoriasis, eczema; very seldom – a reversible depigmentation, a reversible hyperpegmentation, periorbital hypostasis or a face edema, reversible development of a photosensitization.

Besides, use of cream and ointment can cause contact dermatitis: cream – it is frequent, ointment – infrequently.

Special instructions

Dayvoneks's drawing on the person is contraindicated. After each use it is necessary to wash up carefully hands to avoid accidental contact of drug with face skin.

It is impossible to apply cream and ointment on the sites of skin exceeding 30% of a body surface. In the presence at patients of chronic psoriasis in a severe form use of drug has to be followed by careful monitoring of level of content of calcium in urine and blood as at this category of patients intensity of absorption and risk of development of a hypercalcemia increases.

It is impossible to exceed the recommended dosing of a kaltsipotriol. After drug withdrawal the level of concentration of calcium in blood is normalized quickly.

At simultaneous use of solution with cream or ointment it is necessary to consider a total dose of a kaltsipotriol which should not exceed 0,005 g a week (1 g of cream or ointment of Dayvoneks there corresponds 1 ml of solution for head skin).

Content of cetostearyl alcohol in cream can promote emergence of rash.

During treatment patients are recommended to avoid excessive influence of direct sunshine. According to the recommendation of the doctor treatment can be combined with influence of light of an ultra-violet lamp, PUVA-and the selection therapy.

Use of ointment for patients aged up to 18 years is recommended only by short courses and on small sites of a skin surface.

Дайвонекс does not exert impact on ability of the patient to control of vehicles and mechanisms.

Medicinal interaction

Contraindicated simultaneous use of a kaltsipotriol with medicines of salicylic acid for external use.

Terms and storage conditions

To store at a temperature up to 25 °C. To protect from children.

Period of validity: solution – 3 years, cream and ointment – 2 years (after opening of a tuba – 6 months).